Zobrazeno 1 - 10
of 39
pro vyhledávání: '"K. J. Kellar"'
Autor:
H, Fan, U A, Scheffel, P, Rauseo, Y, Xiao, A S, Dogan, F, Yokoi, J, Hilton, K J, Kellar, D F, Wong, J L, Musachio
Publikováno v:
Nuclear medicine and biology. 28(8)
Three 3-pyridyl ether nicotinic ligands-(S)-5-Iodo-3-[(2-pyrrolidinyl)-methoxy]pyridine (5-iodo-A-85865), (S)-5-Iodo-3-[1-(methyl)-2-pyrrolidinyl-methoxy]pyridine (5-Iodo-A-84543), and (S)-5-iodo-3-[1-methyl-(2-azetidinyl)-methoxy]pyridine (5-iodo-N-
Publikováno v:
Journal of neurochemistry. 79(2)
Neuronal nicotinic acetylcholine receptors (nAChRs) play a significant role in sympathetic transmission in the superior cervical ganglia (SCG), with most of the signal carried by a nAChR containing an alpha3 subunit. Work has shown that transection o
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(1)
The opioid agonist properties of (+/-)-methadone are ascribed almost entirely to the (-)-methadone enantiomer. To extend our knowledge of the pharmacological actions of methadone at ligand-gated ion channels, we investigated the effects of the two en
Publikováno v:
Molecular pharmacology. 60(3)
Effects of agonists on rat alpha 3 beta 4 nicotinic acetylcholine receptors expressed in KX alpha 3 beta 4R2 cells [human embryonic kidney 293-derived cells] were studied. The potencies of seven agonists varied over a 7000-fold range, with a rank ord
Autor:
M, Ferreira, S N, Ebert, D C, Perry, R P, Yasuda, C M, Baker, M I, Dávila-García, K J, Kellar, R A, Gillis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(2)
In vitro autoradiography using 125I-alpha-bungarotoxin (alpha-BGTx) and anti-alpha7 immunohistochemistry were performed on the dorsal motor nucleus of the vagus (DMV) of sham and chronically vagotomized rats to determine whether the alpha7-nicotinic
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(1)
The purpose of this study was to investigate the effect of microinjection of nicotine and nicotinic receptor antagonists into the dorsal motor nucleus of the vagus (DMV) or medial subnucleus of the tractus solitarius (mNTS) on intragastric (IGP) and
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(3)
Dextromethorphan (DM), a structural analog of morphine and codeine, has been widely used as a cough suppressant for more than 40 years. DM is not itself a potent analgesic, but it has been reported to enhance analgesia produced by morphine and nonste
Autor:
R J, Lukas, J P, Changeux, N, Le Novère, E X, Albuquerque, D J, Balfour, D K, Berg, D, Bertrand, V A, Chiappinelli, P B, Clarke, A C, Collins, J A, Dani, S R, Grady, K J, Kellar, J M, Lindstrom, M J, Marks, M, Quik, P W, Taylor, S, Wonnacott
Publikováno v:
Pharmacological reviews. 51(2)
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
Chronic administration of nicotine increases the density of neuronal cholinergic nicotinic receptors in cells and in rodent brain, and similar increases have been reported in brains from human smokers. To further examine this phenomenon, we measured
Autor:
D C, Perry, K J, Kellar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
Epibatidine, a frog skin alkaloid, is a nicotinic receptor agonist with potent analgesic activity. We used in vitro receptor autoradiographic techniques to map binding sites for [3H]epibatidine in rat brain, and those for another nicotinic agonist, [