Zobrazeno 1 - 10
of 26
pro vyhledávání: '"K. J. Broadley"'
Autor:
J R, Thorne, K J, Broadley
Publikováno v:
Acta pharmacologica Sinica. 22(6)
To determine the role of the epithelium in the responses to adenosine of isolated trachea from ovalbumin-sensitized guinea pigs.Spirally cut tracheal preparations were superfused or immersed in organ baths and transversely cut strips were immersed. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34791bd6c5a8d8c844ada889ccbdd97f
https://pubmed.ncbi.nlm.nih.gov/11747751
https://pubmed.ncbi.nlm.nih.gov/11747751
Autor:
L M, Spruntulis, K J, Broadley
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 31(6)
Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory cell activity. Elevated adenosine levels occur in the lungs after antigen challenge of asthmatics.The aim of this study was to investigate whether the bronchocon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92d9c175e52ca1f6b76b0378a5b68d20
https://pubmed.ncbi.nlm.nih.gov/11422161
https://pubmed.ncbi.nlm.nih.gov/11422161
Autor:
T J, Toward, K J, Broadley
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(1)
This study investigated whether a correlation between airway hyperreactivity (AHR), leukocyte influx, and nitric oxide (NO) existed in guinea pigs chronically exposed to lipopolysaccharide (LPS). The effect of the corticosteroid, dexamethasone, or ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::944ddc2d6717c9a37aa609f179fbb710
https://pubmed.ncbi.nlm.nih.gov/11408555
https://pubmed.ncbi.nlm.nih.gov/11408555
Autor:
S W, Martin, K J, Broadley
Publikováno v:
Canadian journal of physiology and pharmacology. 77(3)
The effects of in vitro incubation of rat isolated left atria, pulmonary artery rings, and aortic rings with isoprenaline (10(-6) M for 6 h) were examined to compare the degree of desensitization of beta1- and beta2-adrenoceptor-mediated functional r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1d3d24414cc6ed3d3ddab1aefa811a6
https://pubmed.ncbi.nlm.nih.gov/10535688
https://pubmed.ncbi.nlm.nih.gov/10535688
Publikováno v:
International archives of allergy and immunology. 118(1)
To determine whether antigen challenge is associated with increased accumulation of leukocytes in the lungs, the pulmonary accumulation of 111In-labelled neutrophils and eosinophils was monitored by gamma scintigraphy.Guinea-pigs were sensitized with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::985984851b2123a686d5a06045e108e0
https://pubmed.ncbi.nlm.nih.gov/9925963
https://pubmed.ncbi.nlm.nih.gov/9925963
Autor:
H, Danahay, K J, Broadley
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 28(4)
The physiological and pharmacological consequences of repeated aero-allergen challenge have not been previously characterized in conscious, sensitized guinea-pigs.This study was undertaken to compare the effects of two anti-inflammatory compounds, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b44f5dcfb3fd28e11f5e3816a66b08a
https://pubmed.ncbi.nlm.nih.gov/9641581
https://pubmed.ncbi.nlm.nih.gov/9641581
Autor:
W R, Ford, K J, Broadley
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 331(3)
The action of the adenosine agonist, 5'-(N-ethylcarboxamido)-adenosine (NECA), at extracellular A2 receptors of guinea-pig and rabbit aortic rings was investigated. A near-maximum relaxant concentration (10(-5) M) of NECA was determined from cumulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7411ef928b4f66f3fb8a3415a1a69b5d
https://pubmed.ncbi.nlm.nih.gov/9125000
https://pubmed.ncbi.nlm.nih.gov/9125000
Autor:
P H, Nederkoorn, H, Timmerman, G M, Donné-Op Den Kelder, D, Timms, A J, Wilkinson, D R, Kelly, K J, Broadley, R H, Davies
Publikováno v:
Receptorschannels. 4(2)
A structural model for a ligand-receptor-Gs alpha-protein complex to function as a GTP synthase is presented. The mechanism which is dependent on the movement and rotation of the G alpha-protein alpha 2-helix is seen to involve the delivery of, at le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bfadadae2835c0438c525444008ed93
https://pubmed.ncbi.nlm.nih.gov/8865363
https://pubmed.ncbi.nlm.nih.gov/8865363
Publikováno v:
Receptorschannels. 2(2)
An alignment of beta 1-adrenoceptor alpha-helices on the bacteriorhodopsin model is compared with an equivalent alignment to m2-muscarinic alpha-helices. A proposed mechanism of ligand-activated trans-membrane proton transfer within alpha-helices III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e093f6b3e7c1370f1b3dcb112c94e128
https://pubmed.ncbi.nlm.nih.gov/7953289
https://pubmed.ncbi.nlm.nih.gov/7953289
Publikováno v:
Biochemical pharmacology. 42(3)
Guinea-pig isolated left atria, paced at 2 Hz were incubated with 86rubidium (86Rb) for 120 min. They were then washed every 2 min for 2 hr, each sample being retained for scintillation counting. Left atrial isometric tension was recorded simultaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a351c14b840b5f158fcbe7068ab9f6f0
https://pubmed.ncbi.nlm.nih.gov/1859468
https://pubmed.ncbi.nlm.nih.gov/1859468