Zobrazeno 1 - 8 of 8 pro vyhledávání: '"K. I. Mackenzie"'
1
Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model
Autor: D C Cooper, M L Bergquist, Pat Wheelan, K I MacKenzie, Sean Ross, Mir Hashim, J D Becherer, Don L. Anderson, B Z Desai, Daniel G. Lang, Xiaozhou Yao, Maggie S. McIntyre
Publikováno v: British Journal of Pharmacology. 154:1446-1456
Background and purpose: Drug-induced prolongation of the QT interval can lead to torsade de pointes, a life-threatening ventricular arrhythmia. Finding appropriate assays from among the plethora of options available to predict reliably this serious a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2b9101dff4148be1f380d000b84782
https://doi.org/10.1038/bjp.2008.267
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2
Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)
Autor: K. I. Mackenzie, L. F. Kruk, M. A. Cukierski, Alice F. Tarantal, G. L. Skiles, A. P. Clarke, G. S. Harris, K. P. Ellsworth, C. P. Peter, Andrew G Hendrickx, D. S. Ablin, M. J. Vanzwieten, S. Prahalada
Publikováno v: Teratology. 55:119-131
In genetic male fetuses, dihydrotestosterone (DHT) plays an important role in normal prostatic and external genital differentiation. The enzyme steroid 5-alpha reductase (5 alpha R) catalyzes the conversion of testosterone (T) to DHT. The importance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4c7dd1bcfa0608f8095d287ec09ea2f
https://doi.org/10.1002/(sici)1096-9926(199702)55:2<119::aid-tera1>3.0.co
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3
Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta)
Autor: S, Prahalada, A F, Tarantal, G S, Harris, K P, Ellsworth, A P, Clarke, G L, Skiles, K I, MacKenzie, L F, Kruk, D S, Ablin, M A, Cukierski, C P, Peter, M J, vanZwieten, A G, Hendrickx
Publikováno v: Teratology. 55(2)
In genetic male fetuses, dihydrotestosterone (DHT) plays an important role in normal prostatic and external genital differentiation. The enzyme steroid 5-alpha reductase (5 alpha R) catalyzes the conversion of testosterone (T) to DHT. The importance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8865224911d250d7c056dc462dd8a918
https://pubmed.ncbi.nlm.nih.gov/9143092
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4
The relative attractiveness of cattle, sheep and goats to Glossina morsitans morsitans Westwood and G. pallidipes Austen (Diptera: Glossinidae) in the Zambesi Valley of Rhodesia
Autor: W. P. Boyt, P. K. I. MacKenzie, R. D. Pilson
Publikováno v: Bulletin of Entomological Research. 68:489-495
A series of investigations was conducted to evaluate the comparative attractiveness of cattle, sheep and goats to Glossina morsitans morsitans Westw. and G. pallidipes Aust. in the Zambesi Valley, Rhodesia. It was shown that cattle are subjected to i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4a7078dac01cdf33e7954bed1ac22d2
https://doi.org/10.1017/s0007485300009469
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5
The relative attractiveness of donkeys, cattle, sheep and goats to Glossina morsitans morsitans Westwood and G. pallidipes Austen (Eiptera: Glossinidae) in a middle-veld area of Rhodesia
Autor: R. D. Pilson, W. P. Boyt, P. K. I. MacKenzie
Publikováno v: Bulletin of Entomological Research. 68:497-500
The comparative attractiveness to Glossina morsitans morsitans Westw. and G. pallidipes Aust. of donkeys, cattle, sheep and goats in the presence of wild game was examined during two investigations in a middle-veld area of Rhodesia. Host preferences
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f681dbfc1f27e144f82b17d2e519811
https://doi.org/10.1017/s0007485300009470
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8
Virulence of two strains of Cowdria ruminantium in mice and their use to predict drug activity against heartwater
Autor: N. McHardy, P. K. I. Mackenzie
Publikováno v: Tropical animal health and production. 16(1)
A study was made of the infectivity of two mouse-adapted strains of Cowdria ruminantium in mice. The Kwanyanga strain was most virulent in Balb/C mice which died nine days after infection with homogenate of liver from infected mice. CD-1 mice were le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b8e90ffc0e6fbf742347e94635027f
https://pubmed.ncbi.nlm.nih.gov/6233776
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