Zobrazeno 1 - 10
of 1 268
pro vyhledávání: '"K. Higgins"'
Autor:
P. Strati, M. Coleman, D. Stevens, S. Ma, C. Patti, M. Levy, I. S. Lossos, P. Ramakrishnan Geethakumari, S. Lam, R. Calvo, K. Higgins, L. Budde
Publikováno v:
HemaSphere, Vol 6, Pp 1019-1020 (2022)
Externí odkaz:
https://doaj.org/article/290c538427004c2bb70ea9fc74afd57f
Autor:
Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2539-2559 (2024)
Abstract There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are hi
Externí odkaz:
https://doaj.org/article/b942500814154714b2e7a3f058d0d828
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract IL-33 plays a significant role in inflammation, allergy, and host defence against parasitic helminths. The model gastrointestinal nematode Heligmosomoides polygyrus bakeri secretes the Alarmin Release Inhibitor HpARI2, an effector protein th
Externí odkaz:
https://doaj.org/article/85989ed30a0b45e5bbb0d7c6e41dd367
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Florent Colomb, Abhishek Jamwal, Adefunke Ogunkanbi, Tania Frangova, Alice R Savage, Sarah Kelly, Gavin J Wright, Matthew K Higgins, Henry J McSorley
Publikováno v:
eLife, Vol 13 (2024)
The parasitic nematode Heligmosomoides polygyrus bakeri secretes the HpARI family, which bind to IL-33, either suppressing (HpARI1 and HpARI2) or enhancing (HpARI3) responses to the cytokine. We previously showed that HpARI2 also bound to DNA via its
Externí odkaz:
https://doaj.org/article/9403e694d6fd4968991cbb1e6f8f000a
Autor:
Mark J. Connolly, Brigitte Piallat, Mohammad Sendi, Babak Mahmoudi, Melinda K. Higgins, Claire-Anne Gutekunst, Annaelle Devergnas, Robert E. Gross
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34257- (2024)
Asynchronous distributed multielectrode stimulation (ADMES) is a novel approach to deep brain stimulation for medication resistant temporal lobe epilepsy that has shown promise in rodent and in vitro seizure models. To further evaluate its effects on
Externí odkaz:
https://doaj.org/article/7f52a02164804ed792ad411d94f090d3
Autor:
Alanna K Higgins
Publikováno v:
Current Developments in Nutrition, Vol 8, Iss 6, Pp 103775- (2024)
Produce prescription programs (PPPs) are place-based interventions at the intersection of public health and local food advocacy. These programs have expanded significantly across the United States since 2010, particularly taking off in the state of W
Externí odkaz:
https://doaj.org/article/bc13443dac164ccb8b14132dc2d30e9f
Publikováno v:
eLife, Vol 12 (2024)
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathog
Externí odkaz:
https://doaj.org/article/6730aab5a1254415b53e756fbdf4bda6
Autor:
Jonathan C. Vincent, Colleen N. Garnett, James B. Watson, Emma K. Higgins, Teresa Macheda, Lydia Sanders, Kelly N. Roberts, Ryan K. Shahidehpour, Eric M. Blalock, Ning Quan, Adam D. Bachstetter
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Neuroinflammation contributes to secondary injury cascades following traumatic brain injury (TBI), with alternating waves of inflammation and resolution. Interleukin-1 (IL-1), a critical neuroinflammatory mediator originating from brain endo
Externí odkaz:
https://doaj.org/article/1afd2662b1b249409d8005a54850aaee
Autor:
Re’em Moskovitz, Tossapol Pholcharee, Sophia M. DonVito, Bora Guloglu, Edward Lowe, Franziska Mohring, Robert W. Moon, Matthew K. Higgins
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract The symptoms of malaria occur during the blood stage of infection, when the parasite replicates within human red blood cells. The human malaria parasite, Plasmodium vivax, selectively invades reticulocytes in a process which requires an inte
Externí odkaz:
https://doaj.org/article/b27637cab0cc45d297347c1b5dbe5e4c