An investigation of targeted inhibition of transcription factor activity with pyrrole imidazole polyamide (PA) in chronic myeloid leukemia (CML) blast crisis cells

Autor: Glenn A. Burley, Giacomo Padroni, Lorna Jackson, Lijing Fang, Wu Su, Eduardo Gómez-Castañeda, K. Hayatigolkhatmi, Ya-Ching Hsieh, Francesca Pellicano, Heather G. Jørgensen

Publikováno v: Bioorganicmedicinal chemistry letters. 29(18)

Tyrosine kinase inhibitor (TKI) therapy is the standard treatment for chronic phase (CP)-chronic myeloid leukemia (CML), yet patients in blast crisis (BC) phase of CML are unlikely to respond to TKI therapy. The transcription factor E2F1 is a down-st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77d4ff4c3d878717692b8b7e48ff521
https://pubmed.ncbi.nlm.nih.gov/31378570

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Automated workflow for the cell cycle analysis of (non-)adherent cells using a machine learning approach.

Autor: Hayatigolkhatmi K; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., Soriani C; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., Soda E; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., Ceccacci E; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., El Menna O; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., Peri S; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy., Negrelli I; Tethis S.p.A., Milan, Italy., Bertolini G; Tethis S.p.A., Milan, Italy., Franchi GM; Tethis S.p.A., Milan, Italy., Carbone R; Tethis S.p.A., Milan, Italy., Minucci S; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Rodighiero S; Department of Experimental Oncology, European Institute of Oncology-IRCCS, Milan, Italy.

Publikováno v: ELife [Elife] 2024 Nov 22; Vol. 13. Date of Electronic Publication: 2024 Nov 22.