Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry

Autor: Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinu

Externí odkaz: https://doaj.org/article/d65c6d8ddef244efbd66f10b378d8cc2

Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal horn during neuropathic pain

Autor: Laurent Ferron, Erika K. Harding, Maria A. Gandini, Craig Brideau, Peter K. Stys, Gerald W. Zamponi

Publikováno v: iScience, Vol 27, Iss 6, Pp 109973- (2024)

Summary: N- and P/Q-type voltage-gated Ca2+ channels are critical for synaptic transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron cell bodies during neuropathic pain conditions, less is known about their synapt

Externí odkaz: https://doaj.org/article/f7dd9b2885184647aa707d0d4f9e7033

The high energy X-ray probe (HEX-P): magnetars and other isolated neutron stars

Autor: J. A. J. Alford, G. A. Younes, Z. Wadiasingh, M. Abdelmaguid, H. An, M. Bachetti, M. G. Baring, A. Beloborodov, A. Y. Chen, T. Enoto, J. A. García, J. D. Gelfand, E. V. Gotthelf, A. K. Harding, C-P. Hu, A. D. Jaodand, V. Kaspi, C. Kim, C. Kouveliotou, L. Kuiper, K. Mori, M. Nynka, J. Park, D. Stern, J. Valverde, D. J. Walton

Publikováno v: Frontiers in Astronomy and Space Sciences, Vol 10 (2024)

The hard X-ray emission from magnetars and other isolated neutron stars remains under-explored. An instrument with higher sensitivity to hard X-rays is critical to understanding the physics of neutron star magnetospheres and also the relationship bet

Externí odkaz: https://doaj.org/article/0d5033e0213f452d803560def776d0fe

First Detection of Polarization in X-Rays for PSR B0540-69 and Its Nebula

Autor: Fei Xie, Josephine Wong, Fabio La Monaca, Roger W. Romani, Jeremy Heyl, Philip Kaaret, Alessandro Di Marco, Niccolò Bucciantini, Kuan Liu, Chi-Yung Ng, Niccolò Di Lalla, Martin C. Weisskopf, Enrico Costa, Paolo Soffitta, Fabio Muleri, Matteo Bachetti, Maura Pilia, John Rankin, Sergio Fabiani, Iván Agudo, Lucio A. Antonelli, Luca Baldini, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno, Raffaella Bonino, Alessandro Brez, Fiamma Capitanio, Simone Castellano, Elisabetta Cavazzuti, Chien-Ting Chen, Stefano Ciprini, Alessandra De Rosa, Ettore Del Monte, Laura Di Gesu, Immacolata Donnarumma, Victor Doroshenko, Michal Dovčiak, Steven R. Ehlert, Teruaki Enoto, Yuri Evangelista, Riccardo Ferrazzoli, Javier A. Garcia, Shuichi Gunji, Kiyoshi Hayashida, Wataru Iwakiri, Svetlana G. Jorstad, Vladimir Karas, Fabian Kislat, Takao Kitaguchi, Jeffery J. Kolodziejczak, Henric Krawczynski, Luca Latronico, Ioannis Liodakis, Simone Maldera, Alberto Manfreda, Frédéric Marin, Andrea Marinucci, Alan P. Marscher, Herman L. Marshall, Francesco Massaro, Giorgio Matt, Ikuyuki Mitsuishi, Tsunefumi Mizuno, Michela Negro, Stephen L. O’Dell, Nicola Omodei, Chiara Oppedisano, Alessandro Papitto, George G. Pavlov, Abel L. Peirson, Matteo Perri, Melissa Pesce-Rollins, Pierre-Olivier Petrucci, Andrea Possenti, Juri Poutanen, Simonetta Puccetti, Brian D. Ramsey, Ajay Ratheesh, Oliver J. Roberts, Carmelo Sgrò, Patrick Slane, Gloria Spandre, Douglas A. Swartz, Toru Tamagawa, Fabrizio Tavecchio, Roberto Taverna, Yuzuru Tawara, Allyn F. Tennant, Nicholas E. Thomas, Francesco Tombesi, Alessio Trois, Sergey S. Tsygankov, Roberto Turolla, Jacco Vink, Kinwah Wu, Silvia Zane, IXPE Collaboration, Zorawar Wadiasingh, Wynn C. G. Ho, Alice K. Harding, Keith C. Gendreau, Zaven Arzoumanian

Publikováno v: The Astrophysical Journal, Vol 962, Iss 1, p 92 (2024)

We report on X-ray polarization measurements of the extragalactic Crab-like PSR B0540-69 and its Pulsar Wind Nebula (PWN) in the Large Magellanic Cloud, using a ∼850 ks Imaging X-ray Polarimetry Explorer (IXPE) exposure. The PWN is unresolved by IX

Externí odkaz: https://doaj.org/article/b687c76c03d2480db0b87df28a1b8fee

Study protocol of a randomized controlled trial comparing two linkage models for HIV prevention and treatment in justice-involved persons

Autor: Sandra A. Springer, Ank E. Nijhawan, Kevin Knight, Irene Kuo, Angela Di Paola, Esther Schlossberg, Cynthia A. Frank, Mark Sanchez, Jennifer Pankow, Randi P. Proffitt, Wayne Lehman, Zoe Pulitzer, Kelly Thompson, Sandra Violette, Kathleen K. Harding, ACTION Cooperative Group

Publikováno v: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-16 (2022)

Abstract Background Persons involved in the justice system are at high risk for HIV and drug overdose upon release to the community. This manuscript describes a randomized controlled trial of two evidence-based linkage interventions for provision of

Externí odkaz: https://doaj.org/article/62e70e93e89746ad881e68fa0dbb853c