Výsledky vyhledávání - "K. H. Vousden"

Human papillomavirus detection by hybrid capture and its possible clinical use

Autor: W P Mason, K H Vousden, P Masterson, A Farthing

Publikováno v: Journal of Clinical Pathology. 47:649-652

AIMS--To determine the sensitivity of the hybrid capture method for human papillomavirus (HPV) detection and potential clinical uses as a screening method for the identification of cervical intraepithelial neoplasia. METHODS--The presence of oncogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e7a31d0acd203014a2b2f154eecc80
https://doi.org/10.1136/jcp.47.7.649

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Papillomaviruses and assays for transforming genes

Autor: K H, Vousden

Publikováno v: Methods in molecular biology (Clifton, N.J.). 8

Human papillomavirus (HPV) research dates back to the turn of the century, when Ciuffo demonstrated that human warts are caused by an infectious agent, only later identified as a virus (1). More recently, the HPVs have generated particular interest,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfb80874df05fe805a84aa012fec3c0f
https://pubmed.ncbi.nlm.nih.gov/21390710

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E2F-1 induced apoptosis

Autor: A C, Phillips, K H, Vousden

Publikováno v: Apoptosis : an international journal on programmed cell death. 6(3)

Members of the E2F family of transcription factors play an important role in regulating the cell cycle, and their activity is often perturbed during the development of human malignancies. More recent work has shown that E2F-1 regulates apoptosis as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b043d130230b3133b1c6252d4d3782e
https://pubmed.ncbi.nlm.nih.gov/11388666

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p53: death star

Autor: K H, Vousden

Publikováno v: Cell. 103(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a1da34a26921e0985c05414d9f13392
https://pubmed.ncbi.nlm.nih.gov/11114324

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Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4A upon immortalization

Autor: J, Munro, F J, Stott, K H, Vousden, G, Peters, E K, Parkinson

Publikováno v: Cancer research. 59(11)

The INK4A locus on human chromosome 9p21 encodes two genes that have been implicated in replicative senescence and tumor suppression, p16INK4A and p14ARF. In contrast to p16INK4A, which is up-regulated to high levels, we were unable to detect p14ARF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e545f3a671edf34ac6e12d25269c0f2
https://pubmed.ncbi.nlm.nih.gov/10363964

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Analysis of the degradation function of Mdm2

Autor: M H, Kubbutat, R L, Ludwig, A J, Levine, K H, Vousden

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(2)

Degradation of the p53 tumor suppressor protein has been shown to be regulated by Mdm2. In this study, we identify regions of Mdm2 that are not required for p53 binding but are essential for degradation. Mdm2 mutants lacking these regions function in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5ad18abbcb90ddbaf3c9fa002d4dcd7
https://pubmed.ncbi.nlm.nih.gov/10074902

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Reversal of p53-induced cell-cycle arrest

Autor: S, Bates, E S, Hickman, K H, Vousden

Publikováno v: Molecular carcinogenesis. 24(1)

Activation of the tumor suppressor protein p53 can lead to arrest in both G1 and G2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9f6cd7c319cf4252d845bd8aa6273b6
https://pubmed.ncbi.nlm.nih.gov/10029405

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Cellular response to DNA damage from a potent carcinogen involves stabilization of p53 without induction of p21(waf1/cip1)

Autor: Qasim A. Khan, Anthony Dipple, K H Vousden

Publikováno v: Carcinogenesis. 18(12)

The effect of a potent mammary carcinogen, anti benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide, on the progress of human mammary carcinoma MCF-7 cells through the cell cycle was investigated. While these cells, which express wild-type p53, were arr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e85b191c1914997dbce6dbd19b44e73
https://pubmed.ncbi.nlm.nih.gov/9450475

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Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP

Autor: A C Phillips, K H Vousden

Publikováno v: The Journal of general virology. 78

The E7 protein encoded by human papillomavirus type 16 shows transforming and immortalizing activities which are mediated, in part, through the interaction of the viral oncoprotein with the pRB protein family. This interaction is not solely responsib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36da9ab90bc3c608f33aa3f751e2a251
https://pubmed.ncbi.nlm.nih.gov/9129664

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Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

Autor: K. H. Vousden, M. H. G. Kubbutat

Publikováno v: Molecular and cellular biology. 17(1)

The p53 tumor suppressor protein is activated in cells in response to DNA damage and prevents the replication of cells sustaining genetic damage by inducing a cell cycle arrest or apoptosis. Activation of p53 is accompanied by stabilization of the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec6ab509a3e066f279c8330a1a40f50
https://pubmed.ncbi.nlm.nih.gov/8972227

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