Zobrazeno 1 - 10
of 85
pro vyhledávání: '"K. H. Jakobs"'
Publikováno v:
Der Urologe. Ausg. A.
Publikováno v:
British journal of pharmacology. 132(8)
Lysosphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine (SPPC) can act on specific G-protein-coupled receptors. Since SPP and SPPC cause renal vasoconstriction, we have investigated their effects on urine and electroly
Autor:
U, Rümenapp, M, Asmus, H, Schablowski, M, Woznicki, L, Han, K H, Jakobs, M, Fahimi-Vahid, C, Michalek, T, Wieland, M, Schmidt
Publikováno v:
The Journal of biological chemistry. 276(4)
The M(3) muscarinic acetylcholine receptor (mAChR) expressed in HEK-293 cells couples to G(q) and G(12) proteins and stimulates phospholipase C (PLC) and phospholipase D (PLD) in a pertussis toxin-insensitive manner. To determine the type of G protei
Publikováno v:
British journal of pharmacology. 130(8)
Sphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine constrict isolated rat intrarenal and mesenteric microvessels in vitro. The present study investigates their effects on the cardiovascular system in vivo in anaesthet
Autor:
Matthias Voss, U. Moller, B. Bauer, P. A. O. Weernink, J. H. Camonis, Robbert H. Cool, K. H. Jakobs, S. Haupenthal, Martina Schmidt
Publikováno v:
The Journal of biological chemistry. 274(49)
Stimulation of phospholipase D (PLD) in HEK-293 cells expressing the M3 muscarinic receptor by phorbol ester-activated protein kinase C (PKC) apparently involves Ral GTPases. We report here that PKC, but not muscarinic receptor-induced PLD stimulatio
Publikováno v:
The Journal of biological chemistry. 274(23)
The three Galphai subunits were independently depleted from rat pituitary GH4C1 cells by stable transfection of each Galphai antisense rat cDNA construct. Depletion of any Galphai subunit eliminated receptor-induced inhibition of basal cAMP productio
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(1)
The clathrin-mediated sequestration pathway is used by non-G protein-coupled receptors (e.g., transferrin receptors) and a large number of G protein-coupled receptors, including beta-2 adrenoceptors and various muscarinic acetylcholine receptor (mACh
Publikováno v:
The Journal of biological chemistry. 273(20)
Sustained stimulation of muscarinic acetylcholine receptors (mAChRs) and other G protein-coupled receptors usually leads to a loss of receptor binding sites from the plasma membrane, referred to as receptor sequestration. Receptor sequestration can o
Publikováno v:
Molecular pharmacology. 53(5)
The lysosphingolipids sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine (SPPC) reportedly increase free cytosolic Ca2+ concentration ([Ca2+]i) in a variety of cell types, apparently by activating G protein-coupled plasma membrane receptor
Publikováno v:
Molecular pharmacology. 53(6)
We recently reported that activation of the highly efficient phospholipase C (PLC) stimulatory m3 muscarinic acetylcholine receptor (mAChR) can induce a long-lasting Gi-mediated heterologous potentiation of PLC stimulation in human embryonic kidney (