Zobrazeno 1 - 10
of 54
pro vyhledávání: '"K. H. Cheeseman"'
Autor:
Mario U. Dianzani, John E. Packer, K H Cheeseman, Mustaq Ahmed, Robin L. Willson, Trevor F. Slater, Chiara Benedetto
Publikováno v:
International Journal of Quantum Chemistry. 18:347-356
The activation of carbon tetrachloride to a free radical product (CCl3) by the NADPH-cytochrome P450 enzyme complex is used as an example to discuss aspects of electron flow in liver endoplasmic reticulum. The CCl3 free radical may bind covalently to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2f4672caf66ddc22b34c3f69eb0725
https://doi.org/10.1002/qua.560180733
https://doi.org/10.1002/qua.560180733
Publikováno v:
Applied Microbiology and Biotechnology. 48:198-203
The CHO320 cell line, engineered to produce human interferon gamma was investigated with regard to its susceptibility to oxidative stress. Batch cultures of the cells grown in a bench-top bioreactor exhibited no marked response to changes in oxygen c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eda1c6fa8295af9f336eb00d9102abf
https://doi.org/10.1007/s002530051038
https://doi.org/10.1007/s002530051038
Autor:
Maria Adelaide Pronzato, Damiano Cottalasso, Nicola Traverso, K H Cheeseman, Patrizio Odetti, Umberto M. Marinari
Publikováno v:
Cell Biochemistry and Function. 14:149-154
Oxidation and glycation are non-enzymatic protein modifications involved in the pathogenesis of aging. We evaluated their possible influences in an in vitro system: albumin was oxidized by gamma-irradiation and then exposed to glycation in vitro. Flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d5e28113a0e23b50048834452d39535
https://doi.org/10.1002/cbf.658
https://doi.org/10.1002/cbf.658
Publikováno v:
Phytotherapy Research. 9:416-420
A series of flavonoids, able to inhibit non-enzymic and enzymic lipid peroxidation, were investigated as inhibitors of cytochrome P-450 mediated reactions (aminopyrine N-demethylation and aniline hydroxylation) in rat liver microsomes. The most poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d66160f970693377e2ccfd31c95744a
https://doi.org/10.1002/ptr.2650090606
https://doi.org/10.1002/ptr.2650090606
Autor:
Patricia J. T. A. Groenen, Enrico Gravela, Hans Bloemendal, Ronald H. P. H. Smulders, M Seccia, W.W. de Jong, K H Cheeseman
Publikováno v:
Biochemical Journal. 295:399-404
beta H-crystallin was exposed to radiolytically generated hydroxyl radicals at defined radical concentrations, and its capacity to act as an amine-acceptor substrate and as an amine-donor substrate for transglutaminase were investigated. [14C]Methyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a0e4776dd2e2d6b158f9bb14acec9a
https://doi.org/10.1042/bj2950399
https://doi.org/10.1042/bj2950399
Publikováno v:
Free Radical Biology and Medicine. 15:281-289
A modified method was developed to measure nM levels of a range of n -alkanals and hydroxyalkenals in biological samples such as blood plasma and tissue homogenates and also in Folch lipid extracts of these samples. Butylated hydroxytoluene (BHT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffc7ca0e071b41ab00b7a00635ed88c
https://doi.org/10.1016/0891-5849(93)90075-6
https://doi.org/10.1016/0891-5849(93)90075-6
Autor:
Frank J. Kelly, K H Cheeseman
Publikováno v:
Comparative Biochemistry and Physiology Part A: Physiology. 105:549-554
1. 1. Using a preterm guinea pig model we examined the impact of oxidative and nutritional stress on the vitamin E status of a number of immature tissues. 2. 2. Liver, brain, lung, red blood cell and plasma α-tocopherol concentrations were measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1208662d5ca910cf43e4888176ff46
https://doi.org/10.1016/0300-9629(93)90433-5
https://doi.org/10.1016/0300-9629(93)90433-5
Autor:
K. H. Cheeseman, T. F. Slater
Publikováno v:
British Medical Bulletin. 49:481-493
Free radicals are chemical species possessing an unpaired electron that can be considered as fragments of molecules and which are generally very reactive. They are produced continuously in cells either as accidental by-products of metabolism or delib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eda22a8c1e10c7db7d2b8ba87612189
https://doi.org/10.1093/oxfordjournals.bmb.a072625
https://doi.org/10.1093/oxfordjournals.bmb.a072625
Publikováno v:
British Journal of Nutrition. 67:457-462
The alpha-tocopherol content of a number of different fetal, neonatal and maternal guinea-pig tissues was determined and compared with plasma and erythrocyte alpha-tocopherol values. During late gestation, the fetal liver appears to act as a storage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f0efdfeecd2e627ff87eb82b034f95
https://doi.org/10.1079/bjn19920050
https://doi.org/10.1079/bjn19920050
Publikováno v:
Biochemical Journal. 274:869-873
1. The effects of free radicals on the capacity of beta L-crystallin to act as a substrate for the enzyme transglutaminase were investigated. 2. beta L-Crystallin was exposed to defined radical species that were generated radiolytically, and transglu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb00cf1fc3735fc8f28fcff75785082
https://doi.org/10.1042/bj2740869
https://doi.org/10.1042/bj2740869