Zobrazeno 1 - 10
of 78
pro vyhledávání: '"K. H. Andy Choo"'
Publikováno v:
PLoS Genetics, Vol 5, Iss 2 (2009)
Externí odkaz:
https://doaj.org/article/99c5763663804e31af8be71483d563a7
Autor:
Michael A. Damore, Florence Pedeutour, Andrew J. Holloway, Owen J. Marshall, Vincent Corbin, Bo W. Kim, Ola Myklebost, Jan Schröder, Ben Lansdell, Arthur Hsu, Leonardo A. Meza-Zepeda, K. H. Andy Choo, Anthony T. Papenfuss, David Thomas, Ross Brookwell, Dale W. Garsed, Jason Li, Leon Di Stefano, Andrew J. Deans, Mark Kowarsky, Zhi-Ping Feng
Publikováno v:
Cancer Cell. 26(5):653-667
SummaryWe isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chro
Autor:
James D. R. McGhie, Jeffrey R. Mann, Melissa A. Anderson, K. H. Andy Choo, Fiona T. M. Chang, F. Lyn Chan, Michelle C. W. Tang, Lee H. Wong
Publikováno v:
Nucleic Acids Research
We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric chromatin in mouse embryonic stem cells. The function of ATRX and H3.3 in the maintenance of telomere chromatin integrity
Autor:
K. H. Andy Choo, Paul Kalitsis
Publikováno v:
Chromosoma. 121:327-340
The centromere is a chromosomal structure that is essential for the accurate segregation of replicated eukaryotic chromosomes to daughter cells. In most centromeres, the underlying DNA is principally made up of repetitive DNA elements, such as tandem
Autor:
Owen J. Marshall, K. H. Andy Choo
Publikováno v:
Chromosoma. 121:169-179
Although centromere protein B (CENP-B) is a highly conserved mammalian centromere protein, its function remains unknown. The presence of the protein is required to form artificial satellite DNA-based centromeres de novo, yet cenpb knockout mice are v
Autor:
Francesca Fernandez, K. H. Andy Choo, Sharon Anne Quinlan, Veronica Collins, Hua Ren, Lyn R. Griffiths
Publikováno v:
Headache: The Journal of Head and Face Pain. 50:965-972
(Headache 2010;50:965-972) Objective.— To evaluate relative telomere length of female migraine patients. Background.— Migraine is a debilitating disorder affecting 6-28% of the population. Studies on the mechanisms of migraine have demonstrated g
Autor:
Emma Gould, Cheryl Dissanayake, Howard R. Slater, David E. Godler, Trent Burgess, Mahmoud Shekari Khaniani, Freya Gehling, K. H. Andy Choo, Flora Tassone, Richard Huggins, Danuta Z. Loesch
Publikováno v:
American Journal of Medical Genetics Part A. :2306-2310
Three allelic classes of expanded CGG trinucleotide repeat in the fragile X mental retardation 1 (FMR1) gene have been recognized. The full mutation, FM (>200 repeats), which causes a Fragile X syndrome, is normally associated with epigenetic silenci
Publikováno v:
Genome Research. 19:2202-2213
The Y centromere sequence of house mouse, Mus musculus, remains unknown despite our otherwise significant knowledge of the genome sequence of this important mammalian model organism. Here, we report the complete molecular characterization of the C57B
Publikováno v:
The Journal of Cell Biology
The histone H3 variant centromere protein A (CENP-A) is central to centromere formation throughout eukaryotes. A long-standing question in centromere biology has been the organization of CENP-A at the centromere and its implications for the structure
Autor:
David Francis, Sara Nouri, Bronwyn K. Kenney, Howard R. Slater, Trent Burgess, Damien L. Bruno, Mark D. Pertile, Fiona Norris, Hua Ren, Jan P. Schouten, K. H. Andy Choo
Publikováno v:
American Journal of Medical Genetics Part A. :2786-2793
Chromosome analysis of spontaneous miscarriages is clinically important but is hampered by frequent tissue culture failure and relatively low-resolution analysis. We have investigated replacement of conventional karyotype analysis with a quantitative