Zobrazeno 1 - 10
of 96
pro vyhledávání: '"K. H A Choo"'
Autor:
Jonathan Ip, Paul Canham, K H Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002919 (2012)
Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are required for the proper assembly of heterochromatin. More recent studies have postulated tha
Externí odkaz:
https://doaj.org/article/6f5656b252bc45f69ef5080e7c43c94c
Autor:
Owen J Marshall, K H Andy Choo
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000370 (2009)
Externí odkaz:
https://doaj.org/article/fa5d65b0850b49e6b09033d40e2e91c6
Publikováno v:
PLoS Genetics, Vol 5, Iss 2 (2009)
Externí odkaz:
https://doaj.org/article/99c5763663804e31af8be71483d563a7
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000354 (2009)
We have previously identified and characterized the phenomenon of ectopic human centromeres, known as neocentromeres. Human neocentromeres form epigenetically at euchromatic chromosomal sites and are structurally and functionally similar to normal hu
Externí odkaz:
https://doaj.org/article/0421c0702a6144c99483c97bd586a007
Autor:
Nicholas C Wong, Lee H Wong, Julie M Quach, Paul Canham, Jeffrey M Craig, Jenny Z Song, Susan J Clark, K H Andy Choo
Publikováno v:
PLoS Genetics, Vol 2, Iss 2, p e17 (2006)
DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we employed a fully sequence-defined ectopic human centromere (or neocentromere) to investigate the r
Externí odkaz:
https://doaj.org/article/364a206b02114fc7b4469d9f238ce8a7
Autor:
Michael A. Damore, Florence Pedeutour, Andrew J. Holloway, Owen J. Marshall, Vincent Corbin, Bo W. Kim, Ola Myklebost, Jan Schröder, Ben Lansdell, Arthur Hsu, Leonardo A. Meza-Zepeda, K. H. Andy Choo, Anthony T. Papenfuss, David Thomas, Ross Brookwell, Dale W. Garsed, Jason Li, Leon Di Stefano, Andrew J. Deans, Mark Kowarsky, Zhi-Ping Feng
Publikováno v:
Cancer Cell. 26(5):653-667
SummaryWe isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6428266d88584277e0a67339a7274f04
Autor:
James D. R. McGhie, Jeffrey R. Mann, Melissa A. Anderson, K. H. Andy Choo, Fiona T. M. Chang, F. Lyn Chan, Michelle C. W. Tang, Lee H. Wong
Publikováno v:
Nucleic Acids Research
We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric chromatin in mouse embryonic stem cells. The function of ATRX and H3.3 in the maintenance of telomere chromatin integrity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5428fee5ebdca7f4133bc0f2fe818e7c
https://doi.org/10.1093/nar/gkt114
https://doi.org/10.1093/nar/gkt114
Autor:
K. H. Andy Choo, Paul Kalitsis
Publikováno v:
Chromosoma. 121:327-340
The centromere is a chromosomal structure that is essential for the accurate segregation of replicated eukaryotic chromosomes to daughter cells. In most centromeres, the underlying DNA is principally made up of repetitive DNA elements, such as tandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725a716034a19d13652c1d9f64a2881a
https://doi.org/10.1007/s00412-012-0369-6
https://doi.org/10.1007/s00412-012-0369-6
Autor:
Owen J. Marshall, K. H. Andy Choo
Publikováno v:
Chromosoma. 121:169-179
Although centromere protein B (CENP-B) is a highly conserved mammalian centromere protein, its function remains unknown. The presence of the protein is required to form artificial satellite DNA-based centromeres de novo, yet cenpb knockout mice are v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e184eb1fd3ee54746b62030bf30346
https://doi.org/10.1007/s00412-011-0348-3
https://doi.org/10.1007/s00412-011-0348-3
Autor:
Francesca Fernandez, K. H. Andy Choo, Sharon Anne Quinlan, Veronica Collins, Hua Ren, Lyn R. Griffiths
Publikováno v:
Headache: The Journal of Head and Face Pain. 50:965-972
(Headache 2010;50:965-972) Objective.— To evaluate relative telomere length of female migraine patients. Background.— Migraine is a debilitating disorder affecting 6-28% of the population. Studies on the mechanisms of migraine have demonstrated g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7fbfa2b10b621e6560cf687eb731fcd
https://doi.org/10.1111/j.1526-4610.2010.01693.x
https://doi.org/10.1111/j.1526-4610.2010.01693.x