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Culture conditions effect properties of the Na+/K+-ATPase pump current in hiPSC cardiomyocytes

Autor: Torsten Christ, K. Gurr, Djemail Ismaili, Arne Hansen, András Horváth, Thomas Eschenhagen

Publikováno v: EP Europace. 23

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): BMBF Background Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) provide an opportunity to study human cardiac

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https://doi.org/10.1093/europace/euab116.577

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P.223 Correlating the pre- and post-operative subjective experience of myelopathic impairments with the objective clinical exam

Autor: AC Friesen, SA Detombe, P Doyle-Pettypiece, W Ng, K Gurr, C Bailey, P Rasoulinejad, F Siddiqi, R Bartha, N Duggal

Publikováno v: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 48:S84-S84

Background: Degenerative cervical myelopathy is a debilitating condition of the spinal column resulting in a progressive, clinically measurable loss of motor and sensory function secondary to spinal cord compression. We sought to correlate the patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a07766cf444b5bf3396c8de0fb36fb13
https://doi.org/10.1017/cjn.2021.446

Combined Spine Conference of the Canadian Spine Society New Zealand Orthopaedic Spine Society, Spine Society of Australia: Fairmont Château Lake Louise, Lake, Louise, Alberta, Tuesday, Feb. 25 to Saturday, Mar. 1, 20141.1.01 The use of suspension radiographs to predict LIV tilt.1.1.02 Surgical correction of adolescent idiopathic scoliosis without fusion: an animal model.1.1.03 Are full torso surface topography postural measurements more sensitive to change than back only parameters in adolescents with idiopathic scoliosis and a main thoracic curve?1.2.04 Restoration of thoracic kyphosis in adolescent idiopathic kyphosis: comparative radiographic analysis of round versus rail rods.1.2.05 Scoliosis surgery in spastic quadriplegic cerebral palsy: Is fusion to the pelvis always necessary? A 4–18-year follow-up study.1.2.06 Identification and validation of pain-related biomarkers surrounding spinal surgery in adolescents.1.3.07 Cervical sagittal deformity develops after PJK in adult throacolumbar deformity correction: radiographic analysis using a novel global sagittal angular parameter, the CTPA.1.3.08 Impact of obesity on complications and patient-reported outcomes in adult spinal deformity surgery.1.3.09 The T1 pelvic angle, a novel radiographic measure of sagittal deformity, accounts for both pelvic retroversion and truncal inclination and correlates strongly with HRQOL.1.4.10 Determining cervical sagittal deformity when it is concurrent with thoracolumbar deformity.1.4.11 The influence of sagittal balance and pelvic parameters on the outcome of surgically treated patients with degenerative spondylolisthesis.1.4.12 Predictors of degenerative spondylolisthesis and loading translation in surgical lumbar spinal stenosis patients.2.1.13 Mechanical allodynia following disc herniation requires intraneural macrophage infiltration and can be blocked by systemic selenium delivery or attenuation of BDNF activity.2.1.14 The effect of alanyl-glutamine on epidural fibrosis in a rat laminectomy model.2.1.15 Anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2: a prospective study of complications.2.2.16 2-year results of a Canadian, multicentre, blinded, pilot study of a novel peptide in promoting lumbar spine fusion.2.2.17 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: long-term change in health-related quality of life.2.2.18 Changes in objectively measured walking performance, function, and pain following surgery for spondylolisthesis and lumbar spinal stenosis.2.3.19 A prospective multicentre observational data-monitored study of minimally invasive fusion to treat degenerative lumbar disorders: complications and outcomes at 1-year follow-up.2.3.20 Assessment and classification of subsidence in lateral interbody fusion using serial computed tomography.2.3.21 Predictors of willingness to undergo spinal and orthopaedic surgery after surgical consultation.2.4.22 Indirect foraminal decompression is independent of facet arthropathy in extreme lateral interbody fusion.2.4.23 Cervical artificial disc replacement with ProDisc-C: clinical and radiographic outcomes with long-term follow-up.2.4.24 Tantalum trabecular metal implants in anterior cervical corpectomy and fusion.3.1.25 Hemangiomas of the spine: results of surgical management and prognostic variables for local recurrence and mortality in a multicentre study.3.1.26 Chondrosarcomas of the spine: prognostic variables for local recurrence and mortality in a multicentre study.3.1.27 Risk factors for recurrence of surgically treated spine schwannomas: analysis of 169 patients from a multicentre international database.3.2.28 Survival pattern and the effect of surgery on health related quality of life and functional outcome in patients with metastatic epidural spinal cord compression from lung cancer — the AOSpine North America prospective multicentre study.3.2.29 A biomechanical assessment of kyphoplasty as a stand-alone treatment in a human cadaveric burst fracture model.3.2.30 What is safer in incompetent vertebrae with posterior wall defects, kyphoplasty or vertebroplasty: a study in vertebral analogs.3.3.31 Feasibility of recruiting subjects for acute spinal cord injury (SCI) clinical trials in Canada.3.3.32 Prospective analysis of adverse events in elderly patients with traumatic spinal cord injury.3.3.33 Does traction before surgery influence time to neural decompression in patients with spinal cord injury?3.4.34 Current treatment of individuals with traumatic spinal cord injury: Do we need age-specific guidelines?3.4.35 Current surgical practice for traumatic spinal cord injury in Canada.3.4.36 The importance of 'time to surgery' for traumatic spinal cord injured patients: results from an ambispective Canadian cohort of 949 patients.3.5.37 Assessment of a novel coil-shaped radiofrequency probe in the porcine spine.3.5.38 The effect of norepinephrine and dopamine on cerebrospinal fluid pressure after acute spinal cord injury.3.5.39 The learning curve of pedicle screw placement: How many screws are enough?4.1.40 Preliminary report from the Ontario Inter-professional Spine Assessment and Education Clinics (ISAEC).4.1.41 A surrogate model of the spinal cord complex for simulating bony impingement.4.1.42 Clinical and surgical predictors of specific complications following surgery for the treatment of degenerative cervical myelopathy: results from the multicentre, prospective AOSpine international study on 479 patients.4.2.43 Outcomes of surgical management of cervical spondylotic myelopathy: results of the prospective, multicentre, AOSpine international study in 479 patients.4.2.44 A clinical prediction rule for clinical outcomes in patients undergoing surgery for degenerative cervical myelopathy: analysis of an international AOSpine prospective multicentre data set of 757 subjects.4.2.45 The prevalence and impact of low back and leg pain among aging Canadians: a cross-sectional survey.4.3.46 Adjacent segment pathology: Progressive disease course or a product of iatrogenic fusion?4.3.47 Natural history of degenerative lumbar spondylolisthesis in patients with spinal stenosis.4.3.48 Changes in self-reported clinical status and health care utilization during wait time for surgical spine consultation: a prospective observational study.4.3.49 The Canadian surgical wait list for lumbar degenerative spinal stenosis has a detrimental effect on patient outcomes.4.3.50 Segmental lordosis is independent of interbody cage position in XLIF.4.3.51 Elevated patient BMI does not negatively affect self-reported outcomes of thoracolumbar surgery.1.5.52 The Spinal Stenosis Pedometer and Nutrition Lifestyle Intervention (SSPANLI): development and pilot.1.5.53 Study evaluating the variability of surgical strategy planning for patients with adult spinal deformity.1.5.54 Atlantoaxial instability in acute odontoid fractures is associated with nonunion and mortality.1.5.55 Peripheral hypersensitivity to subthreshold stimuli persists after resolution of acute experimental disc-herniation neuropathy.1.5.56 Radiation induced lumbar spinal osteonecrosis: case report and literature review.1.5.57 Comparative outcomes and cost-utility following surgical treatment of focal lumbar spinal stenosis compared with osteoarthritis of the hip or knee: Part 2 — estimated lifetime incremental cost-utility ratios.1.5.58 A predictive model of progression for adolescent idiopathic scoliosis based on 3D spine parameters at first visit.1.5.59 Development of a clinical prediction model for surgical decision making in patients with degenerative lumbar spine disease.2.5.60 Canadian spine surgery fellowship education: evaluating opportunity in developing a nationally based training curriculum.2.5.61 Pedicle subtraction osteotomy for severe proximal thoracic junctional kyphosis.2.5.62 A comparison of spine surgery referrals triaged through a multidisciplinary care pathway versus conventional referrals.2.5.63 Results and complications of posterior-based 3 column osteotomies in patients with previously fused spinal deformities.2.5.64 Orthopaedic Surgical AdVerse Event Severity (Ortho-SAVES) system: identifying opportunities for improved patient safety and resource utilization.2.5.65 Spontaneous spinal extra-axial haematomas — surgical experience in Otago and Southland 2011–2013.2.5.66 Obesity and spinal epidural lipomatosis in cauda equina syndrome.2.5.67 Factors affecting restoration of lumbar lordosis in adult degenerative scoliosis patients treated with lateral trans-psoas interbody fusion.3.6.68 Systematic review of complications in spinal surgery: a comparison of retrospective and prospective study design.3.6.69 Postsurgical rehabilitation patients have similar fear avoidance behaviour levels as those in nonoperative care.3.6.70 Outcomes of surgical treatment of adolescent spondyloptosis: a case series.3.6.71 Surgical success in primary versus revision thoracolumbar spine surgery.3.6.72 The effect of smoking on subjective patient outcomes in thoracolumbar surgery.3.6.73 Modelling patient recovery to predict outcomes following elective thoracolumbar surgery for degenerative pathologies.3.6.74 Outcomes from trans-psoas versus open approaches in the treatment of adult degenerative scoliosis.3.6.75 Lumbar spinal stenosis and presurgical assessment: the impact of walking induced strain on a performance-based outcome measure

Autor: S. Passmore, E. Huang, N.A. Manson, E.P. Abraham, P. Missiuna, C. Gregg, J. Street, S. Sridharan, D. Cushnie, R. Johnson, Y.R. Rampersaud, S. Lewis, C. Wilgenbusch, J. Larouche, G. Hardy St-Pierre, M.-L. Nault, J. Manson, M. Shamji, N. Evaniew, P. Phan, C. Tomkins-Lane, A. Morokoff, J. Urquhart, A. Fernandes, R. Johnstone, A. Jack, R. Rampersaud, L. Tetreault, M. Fehlings, C. Sparrey, P. Wilde, F. Altaf, P. Pezeshki, M. Dvorak, B. Drew, H. Ahn, C. Pinkoski, A. Patel, S.D. Christie, Z. Sardar, E. Wong, C. Fisher, C. Goldstein, V. King, G. Malham, N. Manson, P. Jarzem, K. Haugo, R. Amritanand, I. Radovanovic, T. Protopsaltis, A. Soroceanu, C. Ferland, B. Hodgson, S. Samuel, E. Parent, H. van West, J.-M. Mac-Thiong, H. Labelle, D. Moulin, I. Turgeon, M. Roy-Beaudry, N. Bourassa, Y. Petit, S. Parent., S. Chabot, L. Westover, D. Hill, M. Moreau, D. Hedden, E. Lou, S. Adeeb., M. Smith, C. Bridge, B. Hsu, R. Gray., PORSCHE Study Group, N. Saran, L. Stone, J. Ouellet., J. Terran, N. Bronsard, J. Smith, E. Klineberg, G. Mundis, R. Hostin, R. Hart, C. Shaffrey, S. Bess, C. Ames, F. Schwab, V. Lafage., V. Lafage, T. Errico., J.S. Smith, D. Burton, T. Errico, H. Jo Kim, V. Gananapathy, F. Siddiqi, K. Gurr, C. Bailey, B. Ravi, K. David, R. Rampersaud., Y.S. Tu, M. Salter., H. Nichol, D. Fourney, M. Kelly., R. Parker, N. Ellis, C. Blecher, F. Chow, M. Claydon., D. Alexander, W. Oxner, S. du Plessis, A. Yee, E. Wai., S.J. Lewis, J.R. Davey, R. Gandhi, N. Mahomed., R. Hu, K. Thomas, C. Hepler, K. Choi, K. Rowed, A. Haig., K. Lam., K. Seex., A.V. Perruccio, UHN Arthritis Program., B. Goss, Z. Ballok., P. Chan, D. Varma., A. Swart, M. Winder, P. Pal Varga, Z. Gokaslan, S. Boriani, A. Luzzati, L. Rhines, D. Chou, R. Williams, M. Dekutoski, N. Quraishi, C. Bettegowda, N. Kawahara, M. Fehlings., A. Versteeg, R.P. Williams, J. Reynolds, L. Rhines., J. Zamorano, A. Nater, L. Tetrault, P. Varga, D. Chou., B. Kopjar, A. Vaccaro, P. Arnold, J. Schuster, J. Finkelstein, J. France., C. Whyne, D. Singh, M. Ford., W. Aldebeyan, J. Ouellet, T. Steffen, L. Beckman, M. Weber, P. Jarzem., B.K. Kwon, C.S. Bailey, M.G. Fehlings, D.R. Fourney, D. Gagnon, E.C. Tsai, D. Tsui, S. Parent, J. Chen, V.K. Noonan, C.S. Rivers, RHSCIR Network, J. Batke, B. Lenehan, J. Street., R. Fox, A. Nataraj, N. Duggal, R.J. Hurlbert, A. Townson, N. Attabib, RHSCIR Network., J. Paquet, M.G. Johnson, T. Shen, N. Fallah, S. Davidson, C. McCann, M. Akens, K. Murphy, M. Sherar, A. Yee., L. Belanger, J. Ronco, N. Dea, S. Paquette, M. Boyd, B. Kwon, A. Gonzalvo, G. Fitt, S. Liew, D. de la Harpe, P. Turner, M. Rogers, A. Bidos, C. Fanti, B. Young, D. Puskas., H. Tam, S. Manansala, V. Nosov, M.L. Delva, N. Alshafai, G. Tan, A. Ibrahim, L. Tetrault., K. Sundararajan, S. Eng., G.H. St-Pierre, P. Rosas-Arellano, C. Tallon, K.R. Gurr, S.I. Bailey, P. Rosa-Arellano, S. Bailey, C. Bailey., L. Milili, G. Malham., A.J. Green, M. McKeon, E.P. Abraham., L. Lafave, J. Parnell, J. Rempel, S. Moriartey, Y. Andreas, P. Wilson, H. Ray, R. Hu., A. Ploumis, K. Hess, K. Wood., B. Yarascavitch, K. Madden, M. Ghert, M. Bhandari, D. Kwok, Y.-S. Tu, A. Hadlow., P. Tso, K. Walker, N. Mahomed, P.C. Coyte., J. deGuise, T. Leroux, R. Broad, H. Hall, S. Christie, T. Carey, V. Mehta, V. Wadey., T. Dear, M. Hashem., S. Goldstein, A. Bodrogi, M. Lipkus, S. Keshen, C. Veillette, D. Adams, N. Briggs, J. Lau, R. Magtoto, K.W. Marshall, E. Massicotte, D. Ogilvie-Harris, A. Sarro, K. Syed, N. Mohamed., S. Perera, A. Taha, R. Cho, G. Swamy, C.L. Power, S. Henari, B. Lenehan., G. McIntosh, C. Hoffman., A. Karachi, T. Pazionis, O. AlShaya, N.A. Manson., J. Murray, S. Suttor, T. Goyal, J. Littlewood, I. Bains, J. Bouchard, B. Jacobs, M. Johnson, V. Pelleck, Y. Amad, E. Ramos, C. Glazebrook

Publikováno v: Canadian Journal of Surgery. 57:S18-S46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::259b13eb9415b6e219ae6ddb294f504e
https://doi.org/10.1503/cjs.005614