Zobrazeno 1 - 10
of 219
pro vyhledávání: '"K. Guest"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 121-122 (2024)
OBJECTIVES/GOALS: Current long bone fracture standard of care uses inert metal intramedullary nails (IMN), 10x stiffer than femur cortex. Consequent “stress-shielding” bone loss sees >5% of patients needing revision surgery. To improve nonunion h
Externí odkaz:
https://doaj.org/article/d4614fcfdc0149daa0fb28c0aa7f9cec
Autor:
Helen Xun, Christopher Shallal, Justin Unger, Runhan Tao, Alberto Torres, Michael Vladimirov, Jenna Frye, Mohit Singhala, Brockett Horne, Bo Soo Kim, Broc Burke, Michael Montana, Michael Talcott, Bradford Winters, Margaret Frisella, Bradley S. Kushner, Justin M. Sacks, James K. Guest, Sung Hoon Kang, Julie Caffrey
Publikováno v:
3D Printing in Medicine, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract Background Mechanical ventilators are essential to patients who become critically ill with acute respiratory distress syndrome (ARDS), and shortages have been reported due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-Co
Externí odkaz:
https://doaj.org/article/8b712f001e53495ea803f69d28b5537a
Publikováno v:
Materials & Design, Vol 230, Iss , Pp 111959- (2023)
Complex mechanical systems can generate severe dynamic environments that require materials with optimized combinations of damping properties, elastic moduli, and service temperatures. In this study, woven lattices were manufactured with stainless ste
Externí odkaz:
https://doaj.org/article/e2233cfc6e274dc19d5b2e367a931a75
Autor:
Ricardo Ribas, Sunil Pancholi, Aradhana Rani, Eugene Schuster, Stephanie K. Guest, Joanna Nikitorowicz-Buniak, Nikiana Simigdala, Allan Thornhill, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Mitch Dowsett, Stephen R. Johnston, Lesley-Ann Martin
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Endocrine therapies are the mainstay of treatment for oestrogen receptor (ER)-positive (ER+) breast cancer (BC). However, resistance remains problematic largely due to enhanced cross-talk between ER and growth factor pathways, cir
Externí odkaz:
https://doaj.org/article/d144720f2d924e96b49640bc5c504a90
Autor:
Lesley-Ann Martin, Mitch Dowsett, Barry R. Davies, Stephen Johnston, Gianmaria Liccardi, Aradhana Rani, Hayley Campbell, Urszula M. Polanska, Nikiana Simigdala, Aurélie Thuleau, Qiong Gao, Elisabetta Marangoni, Stephanie K. Guest, Sunil Pancholi, Ricardo Ribas
MCF7 and MCF7-LTED cells lines were cultured in DCC {plus minus} AZD5363 and mRNA analysis performed by RT-qPCR. Error bars represent {plus minus} SEM. *p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b6b2ecbae87c4703d69fc67a915231
https://doi.org/10.1158/1535-7163.22502725
https://doi.org/10.1158/1535-7163.22502725
Autor:
Lesley-Ann Martin, Mitch Dowsett, Barry R. Davies, Stephen Johnston, Gianmaria Liccardi, Aradhana Rani, Hayley Campbell, Urszula M. Polanska, Nikiana Simigdala, Aurélie Thuleau, Qiong Gao, Elisabetta Marangoni, Stephanie K. Guest, Sunil Pancholi, Ricardo Ribas
(A) MCF7 and MCF7-LTED were treated for 1, 8 and 24-hours with the drug combinations indicated (B) T47D, T47D-LTED, ZR75., ZR75-LTED and TamR cell lines were treated for 1-hour as indicated and signalling pathways analysed by immunoblotting. (C) MCF7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb366b71fb3afd3706540444cb035ad
https://doi.org/10.1158/1535-7163.22502731
https://doi.org/10.1158/1535-7163.22502731
Autor:
Lesley-Ann Martin, Mitch Dowsett, Barry R. Davies, Stephen Johnston, Gianmaria Liccardi, Aradhana Rani, Hayley Campbell, Urszula M. Polanska, Nikiana Simigdala, Aurélie Thuleau, Qiong Gao, Elisabetta Marangoni, Stephanie K. Guest, Sunil Pancholi, Ricardo Ribas
Cells lines were treated with the combinations stated above for 24-hours, RNA was extracted and cDNA synthetised. mRNA analysis was performed by RT-qPCR using taqman oligos described in the material and methods. Error bars represent {plus minus} SEM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9844cd451b0204c1bce7c3c54fa7b2e8
https://doi.org/10.1158/1535-7163.22502728
https://doi.org/10.1158/1535-7163.22502728
Autor:
Lesley-Ann Martin, Mitch Dowsett, Barry R. Davies, Stephen Johnston, Gianmaria Liccardi, Aradhana Rani, Hayley Campbell, Urszula M. Polanska, Nikiana Simigdala, Aurélie Thuleau, Qiong Gao, Elisabetta Marangoni, Stephanie K. Guest, Sunil Pancholi, Ricardo Ribas
Cell lines were treated as described with GI50 concentrations of each drug alone or in combination, as indicated in the graphs. For Combination Index Tables shown, each graph cells were treated with AZD5363 and a combination of (A) 4-OHT, (B) fulvest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a73b51f9056fa9cee467bb177b374b
https://doi.org/10.1158/1535-7163.22502737
https://doi.org/10.1158/1535-7163.22502737
Autor:
Lesley-Ann Martin, Mitch Dowsett, Barry R. Davies, Stephen Johnston, Gianmaria Liccardi, Aradhana Rani, Hayley Campbell, Urszula M. Polanska, Nikiana Simigdala, Aurélie Thuleau, Qiong Gao, Elisabetta Marangoni, Stephanie K. Guest, Sunil Pancholi, Ricardo Ribas
PI3K/AKT/mTOR signaling plays an important role in breast cancer. Its interaction with estrogen receptor (ER) signaling becomes more complex and interdependent with acquired endocrine resistance. Targeting mTOR combined with endocrine therapy has sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7077bc7ec2ce97442d2218db500005
https://doi.org/10.1158/1535-7163.c.6537157
https://doi.org/10.1158/1535-7163.c.6537157
Supplementary Fig. S1 from Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer
Autor:
Eric W-F. Lam, R. Charles Coombes, Andreas Polychronis, Jimmy M-M. Kwok, Janna Krol, Stephen S. Myatt, Jun Wang, Stephanie K. Guest, Barrie Peck, Richard E. Francis, Ursula B. McGovern
Supplementary Fig. S1 from Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86252130ef627516354c6d9b135f58bd
https://doi.org/10.1158/1535-7163.22485026
https://doi.org/10.1158/1535-7163.22485026