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Akademický článek

Study protocol for a single-site feasibility study evaluating the adoption and fidelity of Prep-4-RT: prehabilitation for head and neck cancer patients undergoing radiotherapy

Autor: H. Ray, E. Sexton, J. Frowen, K. Gough, S. Turnbull, S. Abo, M. Ftanou, J. Loeliger

Publikováno v: Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-10 (2024)

Abstract Introduction Prep-4-RT is a co-designed stepped-care multimodal prehabilitation program for people scheduled to receive radiotherapy for head and neck cancer (HNC). Prehabilitation, which occurs between diagnosis and treatment commencement,

Externí odkaz: https://doaj.org/article/b72e565570664cea96cfb0831d21eb8f

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Akademický článek

The impact of mass drug administration of antibiotics on the gut microbiota of target populations

Autor: Ethan K. Gough

Publikováno v: Infectious Diseases of Poverty, Vol 11, Iss 1, Pp 1-20 (2022)

Abstract Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA).

Externí odkaz: https://doaj.org/article/5b242ca170e9431da14eb08497e4c59c

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Akademický článek

Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants

Autor: James A Church, Sandra Rukobo, Margaret Govha, Ethan K Gough, Bernard Chasekwa, Benjamin Lee, Marya P Carmolli, Gordana Panic, Natasa Giallourou, Robert Ntozini, Kuda Mutasa, Monica M McNeal, Florence D. Majo, Naume V. Tavengwa, Jonathan R. Swann, Lawrence H Moulton, Beth D Kirkpatrick, Jean H Humphrey, Andrew J Prendergast

Publikováno v: EClinicalMedicine, Vol 41, Iss , Pp 101173- (2021)

Background: Oral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED an

Externí odkaz: https://doaj.org/article/69cb5ba48b6d461b9a9af23e66c7c284

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Metabolic profiling of in vivo right ventricular function and exercise performance in pulmonary arterial hypertension

Autor: Catherine E. Simpson, Julie Coursen, Steven Hsu, Ethan K. Gough, Robert Harlan, Aurelie Roux, Susan Aja, David Graham, Matthew Kauffman, Karthik Suresh, Ryan J. Tedford, Todd M. Kolb, Stephen C. Mathai, Paul M. Hassoun, Rachel L. Damico

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L836-L848

In this cohort of patients with pulmonary arterial hypertension (PAH), we investigate metabolomic associations with comprehensive right ventricular (RV) functional measurements derived from multibeat RV pressure-volume loop analysis. Our results show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::004f8d2b6ed8aa02d9039f007895fe00
https://doi.org/10.1152/ajplung.00003.2023

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Akademický článek

Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural Zimbabwe.

Publikováno v: EBioMedicine, Vol 68, Iss , Pp 103421- (2021)

Background: Preterm birth and low birth weight (LBW) affect one in ten and one in seven livebirths, respectively, primarily in low-income and middle-income countries (LMIC) and are major predictors of poor child health outcomes. However, both have be

Externí odkaz: https://doaj.org/article/66cbdb212225430e9f760331de1f448e

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Akademický článek

Mixed results with baricitinib in biological-resistant adult-onset Still’s disease and undifferentiated systemic autoinflammatory disease

Autor: Maya H Buch, Sinisa Savic, Dennis G McGonagle, Mark Kacar, John Fitton, Andrew K Gough

Publikováno v: RMD Open, Vol 6, Iss 2 (2020)

This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still’s disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory

Externí odkaz: https://doaj.org/article/2c6af0472d784fe69198cae1d38e7860

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Akademický článek

Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: A cluster-randomized controlled trial.

Autor: Ethan K Gough, Lawrence H Moulton, Kuda Mutasa, Robert Ntozini, Rebecca J Stoltzfus, Florence D Majo, Laura E Smith, Gordana Panic, Natasa Giallourou, Mark Jamell, Peter Kosek, Jonathan R Swann, Jean H Humphrey, Andrew J Prendergast, Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial Team

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0007963 (2020)

BackgroundEnvironmental enteric dysfunction (EED) may be an important modifiable cause of child stunting. We described the evolution of EED biomarkers from birth to 18 months in rural Zimbabwe and tested the independent and combined effects of improv

Externí odkaz: https://doaj.org/article/434dd9c1355c42688d99c54e66c533e8

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