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Akademický článek

Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins

Autor: Tanya R. McKitrick, Steffen M. Bernard, Alexander J. Noll, Bernard C. Collins, Christoffer K. Goth, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Brantley R. Herrin, Ian A. Wilson, Max D. Cooper, Richard D. Cummings

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)

McKitrick et al engineer and characterize a novel lamprey antibody that recognizes terminal sulfated galactose epitopes on mammalian glycoproteins. This provides a new tool for the exploration of glycoprotein sulfation in mammalian cells, which could

Externí odkaz: https://doaj.org/article/fc44f226d9cf4dce8756ecf26052d69b

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Akademický článek

An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

Autor: Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate p

Externí odkaz: https://doaj.org/article/d81560792a8349198626ee05e6f9d81f

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Akademický článek

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'Glyco-sulfo barcodes' regulate chemokine receptor function

Autor: Lisa Verhallen, Jarkko J. Lackman, Rikke Wendt, Martin Gustavsson, Zhang Yang, Yoshiki Narimatsu, Daniel M. Sørensen, Kato Mac Lafferty, Mieke Gouwy, Pedro E. Marques, Gertrud M. Hjortø, Mette M. Rosenkilde, Paul Proost, Christoffer K. Goth

Publikováno v: Verhallen, L, Lackman, J J, Wendt, R, Gustavsson, M, Yang, Z, Narimatsu, Y, Sørensen, D M, Lafferty, K M, Gouwy, M, Marques, P E, Hjortø, G M, Rosenkilde, M M, Proost, P & Goth, C K 2023, ' “Glyco-sulfo barcodes” regulate chemokine receptor function ', Cellular and Molecular Life Sciences, vol. 80, no. 2, 55 . https://doi.org/10.1007/s00018-023-04697-9

Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including O-glycosylation and tyrosine sulfation have been reported to regulate ligand binding and resulting sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6526cd97ea1fe546f51b09c8129a33f
https://doi.org/10.1007/s00018-023-04697-9

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Akademický článek

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G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications

Autor: Ulla E. Petäjä-Repo, Mette M. Rosenkilde, Christoffer K. Goth

Publikováno v: ACS Pharmacol Transl Sci

[Image: see text] Post-translational modifications (PTMs) are a fundamental phenomenon across all classes of life and several hundred different types have been identified. PTMs contribute widely to the biological functions of proteins and greatly inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7707e85bc298c7785fbc4d440fe23236
https://doi.org/10.1021/acsptsci.0c00016

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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

Publikováno v: Jorgensen, A S, Brandum, E P, Mikkelsen, J M, Orfin, K A, Boilesen, D R, Egerod, K L, Moussouras, N A, Vilhardt, F, Kalinski, P, Basse, P, Chen, Y-H, Yang, Z, Dwinell, M B, Volkman, B F, Veldkamp, C T, Holst, P J, Lahl, K, Goth, C K, Rosenkilde, M M & Hjorto, G M 2021, ' The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus ', Cellular and Molecular Life Sciences, vol. 78, pp. 6963-6978 . https://doi.org/10.1007/s00018-021-03930-7
Cellular and Molecular Life Sciences

The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0dd3d59f2ffef71bf371daee644900
https://curis.ku.dk/portal/da/publications/the-cterminal-peptide-of-ccl21-drastically-augments-ccl21-activity-through-the-dendritic-cell-lymph-node-homing-receptor-ccr7-by-interaction-with-the-receptor-nterminus(75fed330-7fae-4e10-a0b1-7fbac9b559e0).html

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Akademický článek

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Akademický článek

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Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor

Autor: Jens P. Goetze, Henrik Clausen, Christoffer K. Goth, Thomas Daugbjerg Madsen, John C. Burnett, Jens F. Rehfeld, Sergey Y. Vakhrushev, Katrine T. Schjoldager, S. Jeson Sangaralingham, Seethalakshmi R. Iyer, Nina Dzhoyashvili, Lasse H Hansen, Yang Chen

Publikováno v: Hansen, L H, Madsen, T D, Goth, C K, Clausen, H, Chen, Y, Dzhoyashvili, N, Iyer, S R, Sangaralingham, S J, Burnett, J C, Rehfeld, J F, Vakhrushev, S Y, Schjoldager, K T & Goetze, J P 2019, ' Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor ', Journal of Biological Chemistry, vol. 294, no. 34, pp. 12567-12578 . https://doi.org/10.1074/jbc.RA119.008102

Atrial natriuretic peptide (ANP) is a peptide hormone that in response to atrial stretch is secreted from atrial myocytes into the circulation, where it stimulates vasodilatation and natriuresis. ANP is an important biomarker of heart failure where l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bc8085a4d0619e231c5a06ad94e0c
https://doi.org/10.1074/jbc.ra119.008102

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