Zobrazeno 1 - 10
of 1 706
pro vyhledávání: '"K. Glass"'
Publikováno v:
BMC Public Health, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Effective syndromic surveillance alongside COVID-19 testing behaviours in the population including in higher risk and hard to reach subgroups is vital to detect re-emergence of COVID-19 transmission in the community. The aim of th
Externí odkaz:
https://doaj.org/article/053e4faebdb44e1a8d39611b8ed26a93
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Following implementation of strong containment measures, several countries and regions have low detectable community transmission of COVID-19. We developed an efficient, rapid, and scalable surveillance strategy to detect remainin
Externí odkaz:
https://doaj.org/article/acf37b5a30af4094b69aa0a1ae8fa682
Publikováno v:
International Journal of Infectious Diseases, Vol 101, Iss , Pp 338-339 (2020)
Externí odkaz:
https://doaj.org/article/2cdf9ced0be54174baa7c665210ef8c4
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Autor:
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic m
Externí odkaz:
https://doaj.org/article/4c0ae1d7d594437b8f6bf9199fd5b7f6
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Growing evidence suggests that distal regulatory elements are essential for cellular function and states. The sequences within these distal elements, especially motifs for transcription factor binding, provide critical information
Externí odkaz:
https://doaj.org/article/aefa80940a344705bc428ea31928aed4
Autor:
Enchen Zhou, Xiaoke Ge, Hiroyuki Nakashima, Rumei Li, Hendrik J P van der Zande, Cong Liu, Zhuang Li, Christoph Müller, Franz Bracher, Yassene Mohammed, Jan Freark de Boer, Folkert Kuipers, Bruno Guigas, Christopher K Glass, Patrick C N Rensen, Martin Giera, Yanan Wang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp 1-15 (2023)
Abstract Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models. Desmosterol, which is converted by Δ24‐dehydrocholesterol reductase (DHCR24) into choles
Externí odkaz:
https://doaj.org/article/4c911682d99b44c88efeac537e3e77c7
Autor:
Zeyang Shen, Rick Z Li, Thomas A Prohaska, Marten A Hoeksema, Nathan J Spann, Jenhan Tao, Gregory J Fonseca, Thomas Le, Lindsey K Stolze, Mashito Sakai, Casey E Romanoski, Christopher K Glass
Publikováno v:
eLife, Vol 11 (2022)
Regulation of gene expression requires the combinatorial binding of sequence-specific transcription factors (TFs) at promoters and enhancers. Prior studies showed that alterations in the spacing between TF binding sites can influence promoter and enh
Externí odkaz:
https://doaj.org/article/98d44d7ff9f64f50bf3ced74f1b45425
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 15:1351-1369
Autor:
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brône, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J.L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta González, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valérie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray
Publikováno v:
Neuron
Neuron, vol 110, iss 21
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, de Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L-J & Wyss-Coray, T 2022, ' Microglia states and nomenclature : A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron 110(21), 3458-3483 (2022). doi:10.1016/j.neuron.2022.10.020
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, De Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L J & Wyss-Coray, T 2022, ' Microglia states and nomenclature: A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron, 2022, 110 (21), pp.3458-3483. ⟨10.1016/j.neuron.2022.10.020⟩
Neuron, vol 110, iss 21
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M-E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, de Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L-H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L-J & Wyss-Coray, T 2022, ' Microglia states and nomenclature : A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron 110(21), 3458-3483 (2022). doi:10.1016/j.neuron.2022.10.020
Paolicelli, R C, Sierra, A, Stevens, B, Tremblay, M E, Aguzzi, A, Ajami, B, Amit, I, Audinat, E, Bechmann, I, Bennett, M, Bennett, F, Bessis, A, Biber, K, Bilbo, S, Blurton-Jones, M, Boddeke, E, Brites, D, Brône, B, Brown, G C, Butovsky, O, Carson, M J, Castellano, B, Colonna, M, Cowley, S A, Cunningham, C, Davalos, D, De Jager, P L, de Strooper, B, Denes, A, Eggen, B J L, Eyo, U, Galea, E, Garel, S, Ginhoux, F, Glass, C K, Gokce, O, Gomez-Nicola, D, González, B, Gordon, S, Graeber, M B, Greenhalgh, A D, Gressens, P, Greter, M, Gutmann, D H, Haass, C, Heneka, M T, Heppner, F L, Hong, S, Hume, D A, Jung, S, Kettenmann, H, Kipnis, J, Koyama, R, Lemke, G, Lynch, M, Majewska, A, Malcangio, M, Malm, T, Mancuso, R, Masuda, T, Matteoli, M, McColl, B W, Miron, V E, Molofsky, A V, Monje, M, Mracsko, E, Nadjar, A, Neher, J J, Neniskyte, U, Neumann, H, Noda, M, Peng, B, Peri, F, Perry, V H, Popovich, P G, Pridans, C, Priller, J, Prinz, M, Ragozzino, D, Ransohoff, R M, Salter, M W, Schaefer, A, Schafer, D P, Schwartz, M, Simons, M, Smith, C J, Streit, W J, Tay, T L, Tsai, L H, Verkhratsky, A, von Bernhardi, R, Wake, H, Wittamer, V, Wolf, S A, Wu, L J & Wyss-Coray, T 2022, ' Microglia states and nomenclature: A field at its crossroads ', Neuron, vol. 110, no. 21, pp. 3458-3483 . https://doi.org/10.1016/j.neuron.2022.10.020
Neuron, 2022, 110 (21), pp.3458-3483. ⟨10.1016/j.neuron.2022.10.020⟩
International audience; Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad mi
Autor:
Daniel Q, Huang, Michael, Downes, Ronald M, Evans, Joseph L, Witztum, Christopher K, Glass, Rohit, Loomba
Publikováno v:
Seminars in liver disease, vol 42, iss 4
Semin Liver Dis
Semin Liver Dis
The burden of nonalcoholic fatty liver disease (NAFLD) is rising globally. Cardiovascular disease is the leading cause of death in patients with NAFLD. Nearly half of individuals with NAFLD have coronary heart disease, and more than a third have caro