Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-targeted inhibition of human immunodeficiency virus

Autor: Michael T. Scerba, Mrinmoy Saha, Tracy L. Hartman, X. Xu, Robert W. Buckheit, E. Hughes, A.N. Helfrick, Daniel H. Appella, Nathaniel I. Shank, Matthew Hassink, K. George Rosenker, A.Q. Wang, Lu Yang, Pankaj Gupta

Publikováno v: Antiviral Research

Although the effective use of highly active antiretroviral therapy results in the suppression of virus production in infected individuals, it does not eliminate the infection and low level virus production in cells harboring virus in sanctuary sites.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6c5c7d6ad68415d59fc85ebd25dfe
https://doi.org/10.1016/j.antiviral.2016.08.022

Inhibition of HIV Maturation via Selective Unfolding and Cross-Linking of Gag Polyprotein by a Mercaptobenzamide Acetylator.

Autor: Miller Jenkins LM; Laboratory of Cell Biology , National Cancer Institute, National Institutes of Health , Bethesda , Maryland 20892 , United States., Paine EL; Laboratory of Cell Biology , National Cancer Institute, National Institutes of Health , Bethesda , Maryland 20892 , United States., Deshmukh L, Nikolayevskiy H, Lyons GC; Laboratory of Cell Biology , National Cancer Institute, National Institutes of Health , Bethesda , Maryland 20892 , United States., Scerba MT, George Rosenker K, Luecke HF, Louis JM, Chertova E; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc. , Frederick National Laboratory for Cancer Research , Frederick , Maryland 21701 , United States., Gorelick RJ; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc. , Frederick National Laboratory for Cancer Research , Frederick , Maryland 21701 , United States., Ott DE; AIDS and Cancer Virus Program, Leidos Biomedical Research Inc. , Frederick National Laboratory for Cancer Research , Frederick , Maryland 21701 , United States., Clore GM, Appella DH

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2019 May 22; Vol. 141 (20), pp. 8327-8338. Date of Electronic Publication: 2019 May 13.