Zobrazeno 1 - 10
of 6 033
pro vyhledávání: '"K. George"'
Autor:
Min Liu, Giorgio Bertolazzi, Shruti Sridhar, Rui Xue Lee, Patrick Jaynes, Kevin Mulder, Nicholas Syn, Michal Marek Hoppe, Shuangyi Fan, Yanfen Peng, Jocelyn Thng, Reiya Chua, Jayalakshmi, Yogeshini Batumalai, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Joanne Lee, Susan Swee-Shan Hue, Sheng-Tsung Chang, Shih-Sung Chuang, K. George Chandy, Xiaofei Ye, Qiang Pan-Hammarström, Florent Ginhoux, Yen Lin Chee, Siok-Bian Ng, Claudio Tripodo, Anand D. Jeyasekharan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying prognostic significance across studies in DLBCL, and does not provide a compr
Externí odkaz:
https://doaj.org/article/dcc5aed0ca7744c29e4e5d657125614a
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTThe voltage-gated potassium channel KV1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of KV1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivati
Externí odkaz:
https://doaj.org/article/80bfe485ae704710846065fcf1a10db8
Autor:
Navin Kumar Verma, Brandon Han Siang Wong, Zhi Sheng Poh, Aiswarya Udayakumar, Ritu Verma, Ryan Kwang Jin Goh, Shane P. Duggan, Vishalkumar G. Shelat, K. George Chandy, Nicholas Francis Grigoropoulos
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104216- (2022)
Summary: The tumour microenvironment (TME) imposes a major obstacle to infiltrating T-lymphocytes and suppresses their function. Several immune checkpoint proteins that interfere with ligand/receptor interactions and impede T-cell anti-tumour respons
Externí odkaz:
https://doaj.org/article/5b50fc07ee544566b430049a568a7b97
Autor:
Sanling Liu, Yue Zhao, Hao Dong, Liang Xiao, Yong Zhang, Yuqin Yang, Seow Theng Ong, K. George Chandy, Longhua Zhang, Changlin Tian
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/9d96dfeff9da404090d7dd2ec77fc865
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of “gates” to regulate ion flow through the channels. An important gating mechanism, C-type inactivation, limits
Externí odkaz:
https://doaj.org/article/827421028ee94b0188d27e06ffec8e9d
Publikováno v:
Journal of Veterinary and Animal Sciences, Vol 52, Iss 1, Pp 60-64 (2021)
A feeding trial was done in 18 Malabari kids of 3 months of age (average body weight of 8.29 ± 0.81kg) for a period of 90 days to assess the effect of dietary incorporation of Ksheerabala residue on growth performance and economics of production. Ki
Externí odkaz:
https://doaj.org/article/819a98f6289a41afb822a1e139e1321e
Publikováno v:
Journal of Veterinary and Animal Sciences, Vol 51, Iss 2, Pp 196-200 (2020)
An experiment was conducted with eighteen weaned Malabari kids of three months of age for 90 days to assess the effect of dietary incorporation of Ksheerabala residue on nutrient digestibility and blood biochemical profile in goats. Kids were divided
Externí odkaz:
https://doaj.org/article/b58bc7d24e034cbfae9203a5b145b4c4
Autor:
C. Giatra, E. Souravla, I. Darmani, A. Roumelioti, K. Kaouranis, P. Kosmas, V. Bampali, D. Gardeli, M. Papageorgiou, Z. Mellios, F. Karaolidou, I. Tsonis, M. Karatza, K. George, L. Marinos, D. Karakasis, T. Karmiris, M. Bakiri, M. Bouzani
Publikováno v:
HemaSphere, Vol 6, Pp 1971-1972 (2022)
Externí odkaz:
https://doaj.org/article/284c59d6f1394a679e56967303519eed
Autor:
Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P. Sfikakis, Michael W. Pennington, K. George Chandy, Cornelia Poulopoulou
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that
Externí odkaz:
https://doaj.org/article/0f9684dd16cb45ed9e75cfffbfd1bd3a
Autor:
Zhisheng Her, Joel Heng Loong Tan, Yee-Siang Lim, Sue Yee Tan, Xue Ying Chan, Wilson Wei Sheng Tan, Min Liu, Kylie Su Mei Yong, Fritz Lai, Erica Ceccarello, Zhiqiang Zheng, Yong Fan, Kenneth Tou En Chang, Lei Sun, Shih Chieh Chang, Chih-Liang Chin, Guan Huei Lee, Yock Young Dan, Yun-Shen Chan, Seng Gee Lim, Jerry Kok Yen Chan, K. George Chandy, Qingfeng Chen
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since non-alcoholic steatohepatitis (NASH) involves chr
Externí odkaz:
https://doaj.org/article/7ac32ad7c9604b1b8f09edab482babd4