Zobrazeno 1 - 10
of 115
pro vyhledávání: '"K. Ganser"'
Publikováno v:
Viruses, Vol 16, Iss 7, p 1038 (2024)
In the fullerene cone HIV-1 capsid, the central channels of the hexameric and pentameric capsomers each contain a ring of arginine (Arg18) residues that perform essential roles in capsid assembly and function. In both the hexamer and pentamer, the Ar
Externí odkaz:
https://doaj.org/article/6a5dc485474941068547ea539db67954
Autor:
Sucharita Sarkar, Kaneil K. Zadrozny, Roman Zadorozhnyi, Ryan W. Russell, Caitlin M. Quinn, Alex Kleinpeter, Sherimay Ablan, Hamed Meshkin, Juan R. Perilla, Eric O. Freed, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain
Externí odkaz:
https://doaj.org/article/cbb35289f9cb46858a493c1534ae911c
Autor:
Alvin Yu, Katarzyna A. Skorupka, Alexander J. Pak, Barbie K. Ganser-Pornillos, Owen Pornillos, Gregory A. Voth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsi
Externí odkaz:
https://doaj.org/article/bd9cc94b90814f36bcde658814d9e443
Autor:
Guangai Xue, Klaudia Braczyk, Daniel Gonçalves-Carneiro, Daria M Dawidziak, Katarzyna Sanchez, Heley Ong, Yueping Wan, Kaneil K Zadrozny, Barbie K Ganser-Pornillos, Paul D Bieniasz, Owen Pornillos
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1009202 (2022)
Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation. ZAP is active against both DNA and RNA viruses, including important human pathogens
Externí odkaz:
https://doaj.org/article/818e8e6cae384fec8434905356ad25de
Autor:
Roman Zadorozhnyi, Sucharita Sarkar, Caitlin M. Quinn, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization stat
Externí odkaz:
https://doaj.org/article/21efb9459c7b4027b870d2a182ded22b
Autor:
Laura Odongo, Kaneil K. Zadrozny, William E. Diehl, Jeremy Luban, Judith M. White, Barbie K. Ganser-Pornillos, Lukas K. Tamm, Owen Pornillos
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:45-50
Niemann–Pick C1 protein (NPC1) is a membrane protein that primarily resides in late endosomes and lysosomes, and plays an important role in cholesterol homeostasis in the cell. The second luminal domain of NPC1 (NPC1-C) serves as the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::093c95ddf74108bee21047c87723fb60
https://doi.org/10.1107/s2053230x23000705
https://doi.org/10.1107/s2053230x23000705
Autor:
John M. A. Grime, James F. Dama, Barbie K. Ganser-Pornillos, Cora L. Woodward, Grant J. Jensen, Mark Yeager, Gregory A. Voth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Significant morphological changes occur during the conversion of the immature HIV virion into a mature infectious form. Here the authors use coarse-grained molecular dynamics simulations to model HIV-1 capsid self-assembly and disassembly events that
Externí odkaz:
https://doaj.org/article/cb54a296583545b2ab2085fab3f7c41c
Autor:
Marcin D Roganowicz, Sevnur Komurlu, Santanu Mukherjee, Jacek Plewka, Steven L Alam, Katarzyna A Skorupka, Yueping Wan, Damian Dawidowski, David S Cafiso, Barbie K Ganser-Pornillos, Edward M Campbell, Owen Pornillos
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006686 (2017)
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-spe
Externí odkaz:
https://doaj.org/article/df135015d24340ad92100211730e0580
Autor:
Randall T. Schirra, Nayara F. B. dos Santos, Kaneil K. Zadrozny, Iga Kucharska, Barbie K. Ganser-Pornillos, Owen Pornillos
Upon entry into a new host cell, the HIV-1 capsid performs multiple essential functions, which include shielding the genome from innate immune sensors1, promoting reverse transcription2 and transporting the core from the entry site at the plasma memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e280d4792a13e552d2713701410b1c0c
https://doi.org/10.1101/2022.08.25.505312
https://doi.org/10.1101/2022.08.25.505312
Autor:
F Eckert, K Ganser, B Bender, J Schittenhelm, S Noell, N Stransky, E Hoffmann, D Zips, S Huber, F Paulsen
Publikováno v:
Neuro-Oncology. 24:ii33-ii34
Background Recently, a molecular signature describing the mesenchymal / proneural features of primary stem-cell-enriched glioblastoma cultures was identified correlating with invasiveness, radiation sensitivity and patient-outcome. However, generatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5abdfec1b0da90466f9ad0bcd1e7b4
https://doi.org/10.1093/neuonc/noac174.111
https://doi.org/10.1093/neuonc/noac174.111