Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Autor: K. Verboven, K. Wouters, K. Gaens, D. Hansen, M. Bijnen, S. Wetzels, C. D. Stehouwer, G. H. Goossens, C. G. Schalkwijk, E. E. Blaak, J. W. Jocken

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT phenot

Externí odkaz: https://doaj.org/article/443cd9ffd09742e6ad0690ce44450891

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NK cells in human visceral adipose tissue contribute to obesity-associated insulin resistance through low-grade inflammation.

Autor: Wouters K; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Kusters YHAM; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands.; Top Institute Food and Nutrition, Wageningen, The Netherlands., Bijnen M; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Wetzels S; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands.; Department of Immunology and Biochemistry, Biomedical Research Institute (BIOMED), Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium., Zhang X; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Linssen PBC; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Gaens K; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Houben AJHM; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Joris PJ; Nutrition and Movement Sciences (NUTRIM), MUMC+, Maastricht, The Netherlands.; Top Institute Food and Nutrition, Wageningen, The Netherlands., Plat J; Nutrition and Movement Sciences (NUTRIM), MUMC+, Maastricht, The Netherlands., Kooi ME; Radiology and Nuclear Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., van der Kallen CJH; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Mensink RP; Nutrition and Movement Sciences (NUTRIM), MUMC+, Maastricht, The Netherlands.; Top Institute Food and Nutrition, Wageningen, The Netherlands., Verboven K; Human Biology (NUTRIM), MUMC+, Maastricht, The Netherlands.; Rehabilitation Research Center (REVAL), Biomedical Research Institute (BIOMED), Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium., Jocken J; Human Biology (NUTRIM), MUMC+, Maastricht, The Netherlands., Hansen D; Rehabilitation Research Center (REVAL), Biomedical Research Institute (BIOMED), Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.; Heart Centre Hasselt, Jessa Hospital, Hasselt, Belgium., Blaak EE; Human Biology (NUTRIM), MUMC+, Maastricht, The Netherlands., Ehlers FAI; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands.; Tissue Typing Laboratory, Department of Transplantation Immunology, MUMC+, Maastricht, Netherlands., Wieten L; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands.; Tissue Typing Laboratory, Department of Transplantation Immunology, MUMC+, Maastricht, Netherlands., Greve JW; Department of Surgery (NUTRIM), MUMC+, The Netherlands.; Department of General Surgery, Zuyderland Medical Centre, Heerlen, The Netherlands., Rensen S; Department of Surgery (NUTRIM), MUMC+, The Netherlands., Stehouwer CDA; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands., Schalkwijk CG; Departments of Internal Medicine, MUMC+, Maastricht, The Netherlands.; CARIM School for Cardiovascular Diseases, MUMC+, Maastricht, The Netherlands.; Top Institute Food and Nutrition, Wageningen, The Netherlands.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2020 Oct; Vol. 10 (6), pp. e192.