Zobrazeno 1 - 10
of 135
pro vyhledávání: '"K. Frame"'
Autor:
Ariel K. Frame, Jessica L. Sinka, Marc Courchesne, Rashad A. Muhammad, Sandra Grahovac-Nemeth, Mark A. Bernards, Robert Bartha, Robert C. Cumming
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110342- (2024)
Summary: The astrocyte-neuron lactate shuttle (ANLS) model posits that astrocyte-generated lactate is transported to neurons to fuel memory processes. However, neurons express high levels of lactate dehydrogenase A (LDHA), the rate-limiting enzyme of
Externí odkaz:
https://doaj.org/article/3ed75eb25af84bd4acc33d15401d1d63
Autor:
Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming
The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated lactate is transported to neurons to fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed that lactate shuttling is important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16118bebcaffe599c7b5d11c59eade28
https://doi.org/10.1101/2022.10.19.512981
https://doi.org/10.1101/2022.10.19.512981
Publikováno v:
Planta. 256
Autor:
Ariel K. Frame, Robert C. Cumming
Publikováno v:
Cell metabolism. 34(8)
Astrocytes are brain cells that react to Alzheimer's disease pathology in ways that can have either beneficial or detrimental effects. In this issue of Cell Metabolism, Ju et al. outline a novel strategy for coercing astrocytes to a neuroprotective s
Autor:
David A. Hendrix, Robert C. Cumming, Patrick N. Reardon, Dani M Long, Ariel K. Frame, Jadwiga M. Giebultowicz, Doris Kretzschmar
Publikováno v:
Aging (Albany NY)
Paediatrics Publications
Paediatrics Publications
Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease p
Autor:
M. K. Frame, Ramón Filgueira, Leigh M. Howarth, Thierry Chopin, John Grant, S. Finnis, C. Buchwald, S. D. Costanzo, H. Koepke, D. Jiang
Publikováno v:
Aquaculture Environment Interactions, Vol 11, Pp 671-684 (2019)
Human activities can elevate coastal levels of dissolved inorganic nitrogen (DIN). As macroalgae readily absorb and accumulate DIN, the elemental (total N and C:N ratio) composition of their tissues is less affected by temporal fluctuations compared
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Bio Protoc
The Morris water maze (MWM) is one of the most commonly used tests for assessing spatial learning and memory in mice. While the MWM is highly amenable to testing the effects of memory modifying drugs, most studies do not consider the timing or durati
Autor:
J. Wesley Robinson, Ryley T. Yost, Anne Simon, Ariel K. Frame, Amanda J. Moehring, Dova B Brenman-Suttner
Publikováno v:
Genes, brain, and behaviorREFERENCES. 19(2)
The field of behavioral genetics has recently begun to explore the effect of age on social behaviors. Such studies are particularly important, as certain neuropsychiatric disorders with abnormal social interactions, like autism and schizophrenia, hav
Autor:
Robert C. Cumming, Ariel K. Frame, Richard A. Harris, Asad Lone, Heeseung Lim, Timothy J. Scholl, Francisco Martinez
Publikováno v:
eNeuro
Paediatrics Publications
Paediatrics Publications
The consolidation of newly formed memories and their retrieval are energetically demanding processes. Aerobic glycolysis (AG), also known as the Warburg effect, consists of the production of lactate from glucose in the presence of oxygen. The astrocy