Zobrazeno 1 - 10
of 30
pro vyhledávání: '"K. Files"'
Autor:
Jenna B. Honeycutt, Angela Wahl, Jacob K. Files, Alexis F. League, Barkha J. Yadav-Samudrala, J. Victor Garcia, Sylvia Fitting
Publikováno v:
Retrovirology, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Since the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV) reservoir due to the relatively low penetration of many drugs utilized in cART into the centr
Externí odkaz:
https://doaj.org/article/d5ece5e4edd64dc59a5cd3a175ce3050
Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses
Autor:
Jacob K. Files, Sanghita Sarkar, Tim R. Fram, Sushma Boppana, Sarah Sterrett, Kai Qin, Anju Bansal, Dustin M. Long, Steffanie Sabbaj, James J. Kobie, Paul A. Goepfert, Nathan Erdmann
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
A subset of COVID-19 patients exhibit post-acute sequelae of COVID-19 (PASC), but little is known about the immune signatures associated with these syndromes. We investigated longitudinal peripheral blood samples in 50 individuals with previously con
Externí odkaz:
https://doaj.org/article/f646bc9bc0794fd78c4a08d2e516920f
Autor:
Sushma Boppana, Kai Qin, Jacob K Files, Ronnie M Russell, Regina Stoltz, Frederic Bibollet-Ruche, Anju Bansal, Nathan Erdmann, Beatrice H Hahn, Paul A Goepfert
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009761 (2021)
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 26 convalescent individuals.
Externí odkaz:
https://doaj.org/article/e7e1d82743f64b859cd12f907c6caf75
Publikováno v:
Journal of Investigative Medicine. 71:545-562
In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the global coronavirus disease 2019 (COVID-19) pandemic. Although most infections cause a self-limited syndrome comparable to other upper respiratory viral pathogens
Autor:
Kathryn G. Roberts, Yung-Li Yang, Debbie Payne-Turner, Wenwei Lin, Jacob K. Files, Kirsten Dickerson, Zhaohui Gu, Jack Taunton, Laura J. Janke, Taosheng Chen, Mignon L. Loh, Stephen P. Hunger, Charles G. Mullighan
Publikováno v:
Blood Advances, Vol 1, Iss 20, Pp 1657-1671 (2017)
Abstract: New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a diverse array of kinase-activating alterations (including r
Externí odkaz:
https://doaj.org/article/5dc19ee2c90d4053a50cae2afceaa77b
Publikováno v:
Biology Open, Vol 5, Iss 3, Pp 372-380 (2016)
Mammals express six major somatic linker histone subtypes, all of which display dynamic binding to chromatin, characterized by transient binding at a given location followed by rapid translocation to a new site. Using photobleaching techniques, we sy
Externí odkaz:
https://doaj.org/article/f731ca48017c4b308187c8226871c47c
Autor:
Jacob K. Files, Sarah Sterrett, Sebastian Henostroza, Christopher Fucile, Kevin Maroney, Tim Fram, Simon Mallal, Spyros Kalams, Jonathan Carlson, Alexander Rosenberg, Nathan Erdmann, Anju Bansal, Paul A. Goepfert
Publikováno v:
Journal of Virology. 96
Despite decades of research, an effective HIV-1 vaccine remains elusive. Vaccine strategies leading to the generation of broadly neutralizing antibodies are likely needed to provide the best opportunity of generating a protective immune response agai
Autor:
Anju Bansal, Paul A. Goepfert, Christina Ochsenbauer, Jie Zeng, Jonathan M. Carlson, Andrew Fiore-Gartland, Jeffrey C. Edberg, Sushma Boppana, Kai Qin, Jacob K Files, Robbie B. Mailliard
Publikováno v:
J Virol
HIV frequently escapes CD8 T cell responses, leading to the accumulation of viral adaptations. We recently demonstrated that during chronic HIV infection, adapted epitopes can promote maturation of dendritic cells (DCs) through direct CD8 T cell inte
Duration of post-COVID-19 symptoms is associated with sustained SARS-CoV-2-specific immune responses
Autor:
Timothy R Fram, Kai Qin, Paul A. Goepfert, James J. Kobie, Nathan Erdmann, Anju Bansal, Steffanie Sabbaj, Sarah Sterrett, Jacob K Files, Sanghita Sarkar, Dustin M. Long, Sushma Boppana
Publikováno v:
JCI Insight
A subset of COVID-19 patients exhibit post-acute sequelae of COVID-19 (PASC), but little is known about the immune signatures associated with these syndromes. We investigated longitudinal peripheral blood samples in 50 individuals with previously con
Autor:
Jacob K Files, Beatrice H. Hahn, Anju Bansal, Sushma Boppana, Ronnie M. Russell, Kai Qin, Regina Stoltz, Frederic Bibollet-Ruche, Nathan Erdmann, Paul A. Goepfert
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
T-cell immunity is likely to play a role in protection against SARS-CoV-2 by helping generate neutralizing antibodies. We longitudinally studied CD4 T-cell responses to the M, N, and S structural proteins of SARS-CoV-2 in 21 convalescent individuals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29ff4b0f8e77cbc6b3ea9a1c077c2c6
https://doi.org/10.1101/2020.10.07.20208488
https://doi.org/10.1101/2020.10.07.20208488