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Akademický článek

KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo

Autor: Arafath K. Najumudeen, Sigrid K. Fey, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A. Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Oncogenic KRAS mutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence of KRAS allelic imbalances or gene dosage changes in human cancers, including loss of the wild-ty

Externí odkaz: https://doaj.org/article/cc435f850ded4ca6b07a54a34129b55d

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Akademický článek

Dark force rising: Reawakening and targeting of fetal-like stem cells in colorectal cancer

Autor: Sigrid K. Fey, Nuria Vaquero-Siguero, Rene Jackstadt

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114270- (2024)

Summary: Stem cells play pivotal roles in maintaining intestinal homeostasis, orchestrating regeneration, and in key steps of colorectal cancer (CRC) initiation and progression. Intriguingly, adult stem cells are reduced during many of these processe

Externí odkaz: https://doaj.org/article/425c50dcd39241acbe44f144f6e73e4c

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Akademický článek

Teaching, coaching, or debriefing With Good Judgment: a roadmap for implementing 'With Good Judgment' across the SimZones

Autor: Mary K. Fey, Christopher J. Roussin, Jenny W. Rudolph, Kate J. Morse, Janice C. Palaganas, Demian Szyld

Publikováno v: Advances in Simulation, Vol 7, Iss 1, Pp 1-9 (2022)

Abstract Simulation-based learning occurs in multiple contexts, and one teaching style cannot adequately cover the needs at each learning level. For example, reflective debriefing, often used following a complex simulation case, is not what is needed

Externí odkaz: https://doaj.org/article/30547e2766a649de9a62176be738177b

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Akademický článek

A RAC-GEF network critical for early intestinal tumourigenesis

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Loss of small GTPase RAC1 suppresses intestinal tumorigenesis caused by APC loss, but impacts normal intestinal homeostasis. Here, the authors provide an alternative method of reducing RAC1 activity by the combined targeting of three RAC-GEFs and sho

Externí odkaz: https://doaj.org/article/93c813a5931245bf853878d1057ebcd6

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Akademický článek

Umfrage zur Relevanz der Fächer in der veterinärmedizinischen Lehre und zukünftigen Studienausrichtung bei Tierärztinnen sowie Studierenden in Deutschland

Autor: V Losansky, S Arnhold, J Aschenbach, T Göbel, K Fey, C Kleinsorgen, C Mülling, E Schaper, J Seeger, A Tipold, M Doherr

Publikováno v: Berliner und Münchener Tierärztliche Wochenschrift, Vol 135 (2022)

In Deutschland wird die veterinärmedizinische Ausbildung durch die Verordnung zur Approbation von Tierärztinnen und Tierärzten (TAppV) geregelt. Die Relevanz der in der TAppV aufgeführten Fächer sowie Kernkompetenzen wie Kommunikation und Betrie

Externí odkaz: https://doaj.org/article/8f5b1ef11d7645f8856f93f2d003ebd1

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