Zobrazeno 1 - 10
of 513
pro vyhledávání: '"K. FLEISCHMANN"'
Autor:
Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M König, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K Fleischmann, Daniela Wenzel
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1930-1956 (2024)
Abstract Pulmonary arterial hypertension (PAH) is a life-threatening disease with limited survival. Herein, we propose the pharmacological inhibition of Gq proteins as a novel concept to counteract pulmonary vasoconstriction and proliferation/migrati
Externí odkaz:
https://doaj.org/article/ef4fe65579b14e888b075ebd61269167
Publikováno v:
Geographica Helvetica, Vol 55, Iss 2, Pp 130-137
Menschliche Körper und Räume sind wechselseitig aufeinander bezogen und sehr ähnlichen gesellschaftlichen Konstitutionsbedingungen unterworfen. Dessen ungeachtet wurde der Körper mit seinen Bedeutungen für die Konstruktion und Aneignung von Räu
Externí odkaz:
https://doaj.org/article/bf5ac9a549134fab9d911d14559caf6f
Autor:
Kenichi Kimura, Astrid Ooms, Kathrin Graf-Riesen, Maithreyan Kuppusamy, Andreas Unger, Julia Schuld, Jan Daerr, Achim Lother, Caroline Geisen, Lutz Hein, Satoru Takahashi, Guang Li, Wilhelm Röll, Wilhelm Bloch, Peter F. M. van der Ven, Wolfgang A. Linke, Sean M. Wu, Pitter F. Huesgen, Jörg Höhfeld, Dieter O. Fürst, Bernd K. Fleischmann, Michael Hesse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
An amino acid exchange (P209L) in the human co-chaperone BAG3 gives rise to severe childhood restrictive cardiomyopathy. Here the authors describe humanized transgenic mouse models which phenocopy the disease and provide insight into the pathogenic m
Externí odkaz:
https://doaj.org/article/6cdac892607d45f6a6225c942b322a42
Publikováno v:
Bone Reports, Vol 15, Iss , Pp 101133- (2021)
Mesenchymal stem cells (MSCs) are multipotent and considered to be of great potential for regenerative medicine. We could show recently (Breitbach, Kimura et al. 2018) that a subpopulation of MSCs as well as sinusoidal endothelial cells (sECs) in the
Externí odkaz:
https://doaj.org/article/504113f641e040f49d41e9e7af71105f
Autor:
Aline Schütz, Christin Richter, Petra Weissgerber, Volodymyr Tsvilovskyy, Michael Hesse, Roger Ottenheijm, Frank Zimmermann, Stefanie Buchholz, Rebekka Medert, Sascha Dlugosz, Vladimir Kuryshev, Vladimir Benes, Veit Flockerzi, Bernd K. Fleischmann, Adolfo Cavalié, Marc Freichel
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109851- (2021)
Summary: Early embryogenesis depends on proper control of intracellular homeostasis of ions including Ca2+ and Mg2+. Deletion of the Ca2+ and Mg2+ conducting the TRPM7 channel is embryonically lethal in mice but leaves compaction, blastomere polariza
Externí odkaz:
https://doaj.org/article/11c9f14b7e7c47029d5b6520406b6f06
Autor:
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 57 (2022)
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., as
Externí odkaz:
https://doaj.org/article/ab51b259cd79400aa01e768efdd94017
Autor:
Philipp Makowka, Tobias Bruegmann, Vanessa Dusend, Daniela Malan, Thomas Beiert, Michael Hesse, Bernd K. Fleischmann, Philipp Sasse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Studying adrenergic signalling in the heart requires perfusion with receptor agonists, which lacks cell specificity and spatiotemporal control. Here the authors use the light sensitive G-coupled receptor JellyOp to optogenetically control Gs-signalin
Externí odkaz:
https://doaj.org/article/bdc7336dcc0d428d9963e651e1b882f9
Autor:
Gustavo Monnerat, Micaela L. Alarcón, Luiz R. Vasconcellos, Camila Hochman-Mendez, Guilherme Brasil, Rosana A. Bassani, Oscar Casis, Daniela Malan, Leonardo H. Travassos, Marisa Sepúlveda, Juan Ignacio Burgos, Martin Vila-Petroff, Fabiano F. Dutra, Marcelo T. Bozza, Claudia N. Paiva, Adriana Bastos Carvalho, Adriana Bonomo, Bernd K. Fleischmann, Antonio Carlos Campos de Carvalho, Emiliano Medei
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/a2e0e508ba484f888703530cef72d553
Autor:
Pia Niemann, Miriam Schiffer, Daniela Malan, Sabine Grünberg, Wilhelm Roell, Caroline Geisen, Bernd K. Fleischmann
Publikováno v:
Cells, Vol 11, Iss 4, p 694 (2022)
Connexins (Cx) are a large family of membrane proteins that can form intercellular connections, so-called gap junctions between adjacent cells. Cx43 is widely expressed in mammals and has a variety of different functions, such as the propagation of e
Externí odkaz:
https://doaj.org/article/763f2a5be6624eccb9f9244b1482afb6
Autor:
Kaushalya Kulathunga, Michito Hamada, Yukiko Hiraishi, Mao Otake, Mai Thi Nhu Tran, Olivia Cheng, Junko Tanaka, Tomoki Sakasai, Shota Sakaguchi, Yuka Sugiyama, Bernd K. Fleischmann, Satoru Takahashi, Yoshihiro Miwa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract By using near-infrared fluorescent protein (iRFP)-expressing hematopoietic cells, we established a novel, quantitative, in vivo, noninvasive atherosclerosis imaging system. This murine atherosclerosis imaging approach targets macrophages exp
Externí odkaz:
https://doaj.org/article/4d61aeb86c6e4b90a0b29fc94a27c589