Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells

Autor: K E Truitt, T Nagel, L F Suen, J B Imboden

Publikováno v: The Journal of Immunology. 156:4539-4541

Although under certain conditions an association with phosphatidylinositol 3'-kinase (PI3-K) appears to be critical for CD28 signaling, mutation of the PI3-K binding site (Tyr 170) does not alter the costimulatory ability of murine CD28 (mCD28) in Ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c1bb7499749735b3b306c51c03e675
https://doi.org/10.4049/jimmunol.156.12.4539

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells

Autor: J, Shi, T, Cinek, K E, Truitt, J B, Imboden

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(10)

Perturbation of several distinct T cell molecules, including the CD3/TCR complex, CD7, and CD28, activates phosphatidylinositol 3-kinase (PI3-K), but a clear consensus on the role of PI3-K in T cell activation has yet to emerge. We report here that C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66834f2b046b35e77a387abcb8dd061b
https://pubmed.ncbi.nlm.nih.gov/9144481

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase

Autor: K E, Truitt, J, Shi, S, Gibson, L G, Segal, G B, Mills, J B, Imboden

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(10)

CD28, a cell-surface molecule expressed by T cells, delivers costimulatory signals during the activation of T cells by Ag. Stimulation of CD28 induces its association with phosphatidylinositol 3'-kinase (PI3-K), raising the possibility that PI3-K pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bed3c78f627f7ed8adfc762c43a7f92
https://pubmed.ncbi.nlm.nih.gov/7594470

Monoclonal antibodies and immobilized antibodies

Autor: Robert J. Linhardt, C. W. Abell, R. M. Denney, B. W. Altrock, R. Auerbach, S. D. Bernal, R. E. Canfield, P. H. Ehrlich, W. R. Moyle, T. S. Chan, T. W. Chang, N. T. Chang, J. A. Cidlowski, M. D. Viceps, R. J. Cote, D. M. Morrissey, A. N. Houghton, E. J. Beattie, H. F. Oettgen, L. J. Old, C. M. Croce, R. S. Cubicciotti, A. E. Karu, R. M. Krauss, J. S. Cullor, A. Deutsch, H. Brandwein, H. Platt, D. M. Hunter, A. Dubitsky, S. M. Durham, F. A. Dolbeare, J. W. Gray, G. R. Dreesman, C. E. Kendall, J. C. Egrie, A. R. Frackelton, H. N. Eisen, A. H. Ross, S. Gay, G. Geirnaert, J. E. Geltosky, E. H. Goldberg, E. Goldwasser, C. Kavinsky, T. L. Weiss, H. G. Gratzner, B. Hampar, M. Zweig, S. D. Showalter, H. H. Handley, M. C. Glassy, Y. Hagiwara, H. Hagiwara, C. M. Huang, S. N. Cohen, J. V. Hughes, E. M. Scolnick, J. E. Tomassini, R. Jefferis, J. Steensgaard, H. S. Kaplan, N. N. H. Teng, K. S. Earn, R. F. Calvo, L. Kass, J. R. Kettman, M. V. Norgard, M. B. Khazaeli, W. H. Beierwaltes, B. G. England, P. C. Kung, G. Goldstein, L. Lanier, J. Phillips, N. L. Warner, J. W. Larrick, A. R. Raubitschek, K. E. Truitt, H. Lazarus, J. F. Schwaber, J. Lewicki, C. Lewis, J. V. Olander, W. R. Tolbert, E. L. Milford, C. B. Carpenter, J. M. Paradysz, D. F. Mosher, J. L. Mulshine, J. D. Minna, K. A. Murray, D. M. Neville, R. J. Youle, M. Nicolson, I. Pastan, M. C. Willingham, D. J. Fitzgerald, A. Pucci, A. M. Smithyman, M. B. Slade, P. W. French, G. Wijffels, C. S. Pukel, K. O. Lloyd, L. R. Travassos, W. G. Dippold, R. P. Reckel, J. L. Harris, R. Wellerson, S. M. Shaw, P. M. Kaplan, E. L. Reinherz, S. F. Schlossman, S. C. Mener, J. Sakamoto, C. C. Cordon, E. Friedman, C. L. Finstad, W. E. Enker, M. R. Melamed, J. F. Oettgen, P. J. Scannon, L. E. Spitler, H. M. Lee, R. T. Kawahata, R. P. Mischak, J. Schlom, D. Colcher, M. Nuti, P. H. Hand, F. Austin, G. D. Shockman, D. E. Jackson, W. Wong, Z. Steplewski, H. Koprowski, M. Herlyn, M. Strand, I. S. Trowbridge, D. L. Urdal, C. J. March, S. K. Dower, J. R. Wands, V. R. Zurawski, C. A. White, R. Dulbecco, W. R. Allen, E. C. Arnold, M. Flasher, H. H. Freedman, T. D. Heath, P. Shek, D. Papahadjopoulos, M. Ikeda, S. Sakamoto, K. Suzuki, M. Kuboyama, Y. Harada, A. Kawashiri, E. Takahashi, H. S. Lee, S. Margel, R. C. Nowinski, A. S. Hoffman, J. W. Peterson, K. B. Platt, D. E. Reed, F. X. Real, M. J. Mattes, P. O. Livingston, A. Rembaum, R. C. K. Yen, R. Rosenstein, B. Schneider

Publikováno v: Applied Biochemistry and Biotechnology. 15:53-80

Antibodies in both their free and immobilized state have been the object of considerable industrial and academic interest. A variety of methods are used for preparing and immobilizing antibodies. Applications for monoclonal antibodies include the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53b3e2a60fa089ffc4619eece666554b
https://doi.org/10.1007/bf02798506