Zobrazeno 1 - 10
of 34
pro vyhledávání: '"K. E. Thummel"'
Publikováno v:
Acta anaesthesiologica Scandinavica. 47(6)
Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c99d6bf0e235051425dcdc35c838358
https://pubmed.ncbi.nlm.nih.gov/12803597
https://pubmed.ncbi.nlm.nih.gov/12803597
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(11)
Under certain culture conditions, exposure of the human colon adenocarcinoma cell line Caco-2 to 1,25-(OH)(2)-D(3) induces expression of CYP3A4 to levels comparable to that in human small intestinal epithelium. To determine whether 1,25-(OH)(2)-D(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b085b5c42aa1e613a34261af74f05d6d
https://pubmed.ncbi.nlm.nih.gov/11602520
https://pubmed.ncbi.nlm.nih.gov/11602520
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(12)
Acetaminophen (APAP), a widely used analgesic and antipyretic agent, can cause acute hepatic necrosis in both humans and experimental animals when consumed in large doses. It is generally accepted that N-acetyl-p-benzoquinone imine (NAPQI) is the tox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb0a12cc708083f47bf44397eb27c3ce
https://pubmed.ncbi.nlm.nih.gov/11095574
https://pubmed.ncbi.nlm.nih.gov/11095574
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
To determine the level of FMO1 protein present in human liver tissues, a monospecific antibody was prepared and a sensitive Western blotting procedure with enhanced chemiluminescence detection was developed. Human FMO1, purified from insect cells exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b66b101682fa20f85b71f08adbb7aacf
https://pubmed.ncbi.nlm.nih.gov/10950857
https://pubmed.ncbi.nlm.nih.gov/10950857
Publikováno v:
Pharmaceutical research. 17(3)
The intestinal metabolism of some CYP3A substrates can be altered profoundly by co-administration of the potent inhibitor, ketoconazole. The present research was conducted to test the hypothesis that, unlike the inhibition kinetics observed with isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ef793fa40b39e2b4821ed335bfdb770
https://pubmed.ncbi.nlm.nih.gov/10801218
https://pubmed.ncbi.nlm.nih.gov/10801218
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(1)
Disulfiram (DSF) is a mechanism-based inhibitor of cytochrome P-450 2E1 (CYP2E1), resulting in loss of CYP2E1 protein and activity, which may be useful in preventing CYP2E1-mediated xenobiotic toxicity. The duration of inhibition after a single DSF d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33e9bce14a1672422cd2d4b0b9b92673
https://pubmed.ncbi.nlm.nih.gov/10490907
https://pubmed.ncbi.nlm.nih.gov/10490907
Publikováno v:
Pharmaceutical research. 16(8)
To assess the role of intestinal CYP2D6 in oral first-pass drug clearance by comparing the enzyme content and catalytic activity of a prototype CYP2D6 substrate, metoprolol, between microsomes prepared from human intestinal mucosa and from human live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58647d40b0030dbc7fca8b5bf075e2a9
https://pubmed.ncbi.nlm.nih.gov/10468020
https://pubmed.ncbi.nlm.nih.gov/10468020
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(6)
Disulfiram and its primary metabolite diethyldithiocarbamate are effective mechanism-based inhibitors of cytochrome P-450 2E1 (CYP2E1)1 in vitro. Single-dose disulfiram diminishes CYP2E1 activity in vivo and has been used to identify CYP2E1 participa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::158d3f8e69939368fa8c6b8a645de365
https://pubmed.ncbi.nlm.nih.gov/10348802
https://pubmed.ncbi.nlm.nih.gov/10348802
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(5)
The purpose of this work was to evaluate the effect of mutual unbound inhibitor and unbound enzyme depletion on the potency of three antifungal cytochrome P-450 (CYP)3A inhibitors with over 1000-fold range in enzyme affinity. Incubations were perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aff131baed2dad473aa39bded9c9df5
https://pubmed.ncbi.nlm.nih.gov/10220488
https://pubmed.ncbi.nlm.nih.gov/10220488
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
It has been suggested that the binding of a drug to plasma proteins will influence the intestinal extraction efficiency when drug is delivered to the mucosal epithelium via either the gut lumen or vasculature. We evaluated this hypothesis using cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fabd6479349bbcc04e20255b7a97aa86
https://pubmed.ncbi.nlm.nih.gov/10215698
https://pubmed.ncbi.nlm.nih.gov/10215698