Zobrazeno 1 - 10
of 42
pro vyhledávání: '"K. Dorward"'
Publikováno v:
European Journal of Cancer Care. 24:313-320
This article focuses on a novel method to derive prices for new pharmaceuticals by making price a function of drug performance. We briefly review current models for determining price for a new product and discuss alternatives that have historically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193de8e94210926d76505f04ee05d25c
https://doi.org/10.1111/ecc.12240
https://doi.org/10.1111/ecc.12240
Publikováno v:
Investigational New Drugs. 31:479-487
In contrast to most drugs which are chemically synthesized and have a known structure, biological drugs are derived from living organisms or their products. Biologicals are structurally more complex and unique from chemically synthesized small drug m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987420a50d116c330f1d32f0dce7f0b8
https://doi.org/10.1007/s10637-012-9899-2
https://doi.org/10.1007/s10637-012-9899-2
Publikováno v:
European journal of cancer care. 24(3)
This article focuses on a novel method to derive prices for new pharmaceuticals by making price a function of drug performance. We briefly review current models for determining price for a new product and discuss alternatives that have historically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37ab7744035f890a462672a619afbb94
https://pubmed.ncbi.nlm.nih.gov/25876021
https://pubmed.ncbi.nlm.nih.gov/25876021
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:519-531
The effects of the tricyclic antidepressant, desipramine, on the baroreflex regulation of renal sympathetic nerve activity (SNA) and heart rate (HR), the nasopharyngeal reflex, plasma epinephrine and blood pressure (BP) were studied in conscious rabb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfba368d8d7f9e299d64c7aa6587bfdc
https://doi.org/10.1097/00005344-199104000-00001
https://doi.org/10.1097/00005344-199104000-00001
Autor:
P. K. Dorward, C. D. Rudd
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H770-H778
The role of the brain renin-angiotensin system (RAS) in the baroreflex regulation of renal sympathetic nerve activity (RSNA) and heart rate (HR) was studied in conscious rabbits. RSNA and HR were recorded during slow ramp changes in mean arterial pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d21589d1ea93b23ce99128972a6407
https://doi.org/10.1152/ajpheart.1991.260.3.h770
https://doi.org/10.1152/ajpheart.1991.260.3.h770
Publikováno v:
Hypertension. 16:131-139
We have studied the effect of acute hypertensive episodes on the renal sympathetic baroreceptor reflex in conscious rabbits and the role played by cardiac afferents and endogenous opiate mechanisms. Renal sympathetic nerve activity was recorded durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ee201445d547fccdd56bb657e9622d
https://doi.org/10.1161/01.hyp.16.2.131
https://doi.org/10.1161/01.hyp.16.2.131
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 17:545-555
SUMMARY 1. The stability of the renal sympathetic baroreflex and nasopharyngeal reflex, and the role of cardiac sensory receptors, was studied in conscious rabbits over a 5 h experimental period. 2. Renal sympathetic nerve activity (SNA) was recorded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d43c1aa010950122929cef80c03746
https://doi.org/10.1111/j.1440-1681.1990.tb01355.x
https://doi.org/10.1111/j.1440-1681.1990.tb01355.x
Autor:
Murray D. Esler, P. K. Dorward, Graeme Eisenhofer, C Ferrier, Garry L. Jennings, R. Westerman, B G Wallin
Publikováno v:
The Journal of physiology. 453
1. Muscle sympathetic nerve activity (MSA) was recorded in the peroneal nerve at the knee by microneurography in ten healthy subjects and determinations were made simultaneously of intra-arterial blood pressure, and whole-body and cardiac noradrenali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6866538aef2b10d402d17d77dfd2da04
https://pubmed.ncbi.nlm.nih.gov/1464839
https://pubmed.ncbi.nlm.nih.gov/1464839
Publikováno v:
The American journal of physiology. 261(1 Pt 2)
The relationship between directly recorded renal sympathetic nerve activity (RSNA) and simultaneous renal norepinephrine (NE) spillover rate across the kidney at rest and in response to changes in mean arterial pressure (MAP) was examined in six cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be04c6ff652c911adee139afe16aec9a
https://pubmed.ncbi.nlm.nih.gov/1858903
https://pubmed.ncbi.nlm.nih.gov/1858903
Publikováno v:
Scopus-Elsevier
Peripheral- and central nervous system (CNS)-mediated effects of desipramine (Des) on sympathetic nerves and the contribution of alpha 2-adrenoceptors to these effects were studied in conscious rabbits. Blood pressure, renal sympathetic nerve activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae25b382d8ff6fa4d4a6ff584d7497fe
https://pubmed.ncbi.nlm.nih.gov/1672797
https://pubmed.ncbi.nlm.nih.gov/1672797