Zobrazeno 1 - 10
of 39
pro vyhledávání: '"K. Doak"'
Autor:
T. Walsh, L. Duff, M.-E. Riviere, P.N. Tariot, K. Doak, M. Smith, B. Borowsky, C. Lopez Lopez, P. C. Arratia, F. Liu, I. Scholten, D. Gordon, J. Arbuckle, A. Graf, M. Quinn, J. Ricart, J.B. Langbaum
Publikováno v:
The Journal of Prevention of Alzheimer's Disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b913f76d05835c3d67399f1d6f44e66c
https://doi.org/10.14283/jpad.2023.27
https://doi.org/10.14283/jpad.2023.27
Autor:
Martilias S Farrell, John D McCorvy, Xi-Ping Huang, Daniel J Urban, Kate L White, Patrick M Giguere, Allison K Doak, Alison I Bernstein, Kristen A Stout, Su Mi Park, Ramona M Rodriguiz, Bradley W Gray, William S Hyatt, Andrew P Norwood, Kevin A Webster, Brenda M Gannon, Gary W Miller, Joseph H Porter, Brian K Shoichet, William E Fantegrossi, William C Wetsel, Bryan L Roth
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150602 (2016)
RATIONALE:The sacred lotus (Nelumbo nucifera) contains many phytochemicals and has a history of human use. To determine which compounds may be responsible for reported psychotropic effects, we used in silico predictions of the identified phytochemica
Externí odkaz:
https://doaj.org/article/6d67de2b55b746cc9335cb74037f20c1
Autor:
Hao Fan, Andrej Sali, Brian K. Shoichet, Joel Karpiak, James A. Wells, T. Justin Rettenmaier, Allison K. Doak
Publikováno v:
Journal of Medicinal Chemistry. 58:8285-8291
Finding small molecules that target allosteric sites remains a grand challenge for ligand discovery. In the protein kinase field, only a handful of highly selective allosteric modulators have been found. Thus, more general methods are needed to disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9534bd941fef8bb81a6f8669dd2b836e
https://doi.org/10.1021/acs.jmedchem.5b01216
https://doi.org/10.1021/acs.jmedchem.5b01216
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Brian K. Shoichet, Molly S. Shoichet, Allison K. Doak, Ahil N. Ganesh, Christopher K. McLaughlin, Shawn C. Owen, Lyudmila Nedyalkova
Publikováno v:
ACS Chemical Biology
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration–response curves suggest more complex biological effects, such as multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cff3098ad1389ab7cdcb49c3a23d695
https://doi.org/10.1021/cb4007584
https://doi.org/10.1021/cb4007584
Publikováno v:
Journal of Medicinal Chemistry
Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c7a1370d62eb519dac29cd26922b2d
https://doi.org/10.1021/jm301749y
https://doi.org/10.1021/jm301749y
Publikováno v:
Creative Education. :592-604
Detailed documentations of creative invention are scarce in the professional literature, but could be useful to those engaging in or studying the problem solving process. This investigation describes the creative process of graduate students (7 femal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b267f52122534ccc0e331ab3f1d35d9
https://doi.org/10.4236/ce.2013.49085
https://doi.org/10.4236/ce.2013.49085
Publikováno v:
ACS Chemical Biology
Many small molecules, including bioactive molecules and approved drugs, spontaneously form colloidal aggregates in aqueous solution at micromolar concentrations. Though it is widely accepted that aggregation leads to artifacts in screens for ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba17d3dc00ee786b713495f158a14df
http://europepmc.org/articles/PMC3423826
http://europepmc.org/articles/PMC3423826
Autor:
Brian F. Volkman, Joel Karpiak, Michael M. Mysinger, Brian K. Shoichet, Dahlia R. Weiss, Allison K. Doak, Joshua J. Ziarek, Nikolaus Heveker, Stéphanie Gravel
Publikováno v:
Proceedings of the National Academy of Sciences. 109:5517-5522
G-protein–coupled receptors (GPCRs) are key signaling molecules and are intensely studied. Whereas GPCRs recognizing small-molecules have been successfully targeted for drug discovery, protein-recognizing GPCRs, such as the chemokine receptors, cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fe66bd98ba4430987b6eeecd1e387e
https://doi.org/10.1073/pnas.1120431109
https://doi.org/10.1073/pnas.1120431109
Autor:
Gurgen Tumanian, Kristin T. Ziebart, Da Duan, Allison K. Doak, Teague Sterling, John J. Irwin, Hayarpi Torosyan, Brian K. Shoichet
Publikováno v:
Journal of medicinal chemistry, vol 58, iss 17
Colloidal aggregation of organic molecules is the dominant mechanism for artifactual inhibition of proteins, and controls against it are widely deployed. Notwithstanding an increasingly detailed understanding of this phenomenon, a method to reliably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb13674064d2c3de740b29ba9c4825f5
https://escholarship.org/uc/item/4h68d37t
https://escholarship.org/uc/item/4h68d37t
