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Akademický článek

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Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes

Autor: E. Vandemeulebroucke, P. De Pauw, F. K. Gorus, Ogonnaya C. Ubani, Rui Mao, I. Truyen, C. Van Schravendijk, K. Decochez, I Weets, Daniel Pipeleers, P. N. Jørgensen

Publikováno v: Diabetologia. 48:2322-2329

AIMS/HYPOTHESIS: We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes. MATERIALS AND METHODS: During an initial sampling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218fad0b3d2d27c3f0bf3adf6544c86c
https://doi.org/10.1007/s00125-005-1959-0

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Wat na zwangerschapsdiabetes? Resultaten uit het project Zoet Zwanger

Autor: Roland Devlieger, F. Muylle, Chantal Mathieu, Katrien Benhalima, S. Verstraete, K. Decochez, Ann Verhaegen, Johan Wens

Publikováno v: Huisarts nu: maandblad van de Wetenschappelijke Vereniging van Vlaamse Huisartsen

Vrouwen die zwangerschapsdiabetes hebben gehad, hebben een sterk verhoogd risico om postnataal verder te evolueren naar diabetes type 2. Het project Zoet Zwanger beoogt een betere postnatale opvolging voor deze risicogroep, via de huisarts. Naast een

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efb7d157a90febc765d456bf84fd89c
https://hdl.handle.net/10067/1257580151162165141

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Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies : a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients

Autor: Belgian Diabetes Registry, A Van Dalem, John C. Hutton, Sylvie Tenoutasse, C De Block, Pieter Gillard, Janet M. Wenzlau, Harry Dorchy, Eric V. Balti, Thierry Mouraux, Ilse Weets, K. Decochez, Daniel Pipeleers, Olivier Costa, Frans Gorus, Simke Demeester, Isabel Vermeulen

Publikováno v: Clinical and experimental immunology
Clinical & Experimental Immunology; Vol 171

Summary In first-degree relatives of type 1 diabetic patients, we investigated whether diabetes risk assessment solely based on insulinoma antigen 2 (IA-2) and zinc transporter 8 (ZnT8) antibody status (IA-2A, respectively, ZnT8A) is as effective as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654483608979b7b4d0b24c93303005b6
https://hdl.handle.net/10067/1059540151162165141

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Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes

Autor: I. Truyen, F. K. Gorus, Bart Keymeulen, Daniel Pipeleers, Chantal Mathieu, K. Decochez, Belgian Diabetes Registry, B. Van der Auwera, I. De Leeuw, E. Vandemeulebroucke, R. Rottiers, I Weets

Publikováno v: Diabetologia
Vrije Universiteit Brussel

Aims/hypothesis: Prevention trials in first-degree relatives of type 1 diabetic patients are hampered by large interindividual differences in progression rate to diabetes. We investigated whether specific combinations of immune and genetic markers ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a23e6e60773f6b13b1761dd15aefa
https://hdl.handle.net/10067/1027350151162165141

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[Preventative biology of type 1 diabetes: implications for clinical preventative studies]

Autor: F K, Gorus, I, Weets, K, Decochez, B J, van der Auwera

Publikováno v: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. 65(4)

Type 1 diabetes is a multifactorial disease caused by an interplay of poorly known environmental factors and partially characterized genetic factors. Focal infiltration of the endocrine pancreas by mononuclear cells and a strikingly decreased functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81ba0bd77908c6a2baafa1c4244e8e4b
https://pubmed.ncbi.nlm.nih.gov/14534938

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Akademický článek

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Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes: association with IA-2 and islet cell autoantibodies

Autor: F, Winnock, M R, Christie, M R, Batstra, H J, Aanstoot, I, Weets, K, Decochez, P, Jopart, D, Nicolaij, F K, Gorus

Publikováno v: Diabetes care. 24(7)

To study the association of autoantibodies against a 38-kDa glycated islet cell membrane-associated (GLIMA) protein with (pre)type 1 diabetes, patient characteristics, and other immune and genetic markers of the disease and to evaluate the possible a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07a38790d68bd07133440ea0b8926a1d
https://pubmed.ncbi.nlm.nih.gov/11423499

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Male-to-female excess in diabetes diagnosed in eraly adulthood is not specific for the immune-mediated form nor is it **HLA-DQ** restricted: possible relation to increased body mass index

Autor: I. Weets, J. Van Autreve, B. J. Van der Auwera, F. C. Schuit, M. V. L. Du Caju, K. Decochez, I. H. De Leeuw, B. Keymeulen, C. Mathieu, R. Rottiers, H. Dorchy, E. Quartier, F. K. Gorus, the Belgian Diabetes Registry

Publikováno v: Diabetologia

Aims/hypothesis. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07eafeef1c8839b63ba75f66d8f983
https://hdl.handle.net/10067/349670151162165141

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