Výsledky vyhledávání - "K. C. Zawalich"

Comparative effects of amino acids and glucose on insulin secretion from isolated rat or mouse islets

Autor: Walter S. Zawalich, G Cline, H Yamazaki, K C Zawalich

Publikováno v: Journal of Endocrinology. 183:309-319

Glucose and the combination of leucine and glutamine were used to stimulate insulin secretion from rat islets during a dynamic perifusion and the responses obtained were compared with those elicited from mouse islets under identical conditions. In ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4449ed74447b67f590bfb5e6a17fcef
https://doi.org/10.1677/joe.1.05832

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Regulation of insulin secretion by phospholipase C

Autor: W. S. Zawalich, K. C. Zawalich

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 271:E409-E416

Biphasic insulin secretion in response to a sustained glucose stimulus occurs when rat or human islets are exposed to high levels of the hexose. A transient burst of hormone secretion is followed by a rising and sustained secretory response that, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343816549b68318e26f9182ca5335119
https://doi.org/10.1152/ajpendo.1996.271.3.e409

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Metabolic activation of Ca(2+)-independent phosphoinositide hydrolysis in beta-cells and its role in the control of insulin secretion

Autor: W S Zawalich, K C Zawalich, Howard Rasmussen

Publikováno v: Endocrinology. 136:577-584

Recent studies have led to the proposal that the oxidative metabolism of glucose leads to the generation of messengers, in addition to ATP, that are important in the ability of changes in extracellular glucose concentration to stimulate insulin secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71155de716846da1e8aba9bca00289a5
https://doi.org/10.1210/endo.136.2.7835291

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Inhibitors of phosphatidylinositol 3-kinase amplify insulin release from islets of lean but not obese mice

Autor: K C Zawalich, Walter S. Zawalich, G J Tesz

Publikováno v: The Journal of endocrinology. 174(2)

We examined the effects of phosphatidylinositol 3-kinase (PI3K) inhibition by wortmannin or LY294002 on glucose-induced secretion from mouse islets. Islets were collagenase isolated and perifused or subjected to Western blot analyses and probed for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daf985a30a175c998d77284a1e435e5
https://pubmed.ncbi.nlm.nih.gov/12176663

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A link between insulin resistance and hyperinsulinemia: inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean, but not obese, rats

Autor: W S, Zawalich, K C, Zawalich

Publikováno v: Endocrinology. 141(9)

Wortmannin (5-100 nM), a specific phosphatidyinositol 3-kinase inhibitor, augmented 8 mM glucose-induced insulin secretion from control Sprague Dawley rat islets in a dose-dependent manner. This effect persisted after its removal from the perifusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64212593f3ebde2aff7cb1b993aa234e
https://pubmed.ncbi.nlm.nih.gov/10965900

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Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell

Autor: W S, Zawalich, K C, Zawalich

Publikováno v: The Journal of biological chemistry. 272(6)

The methyl ester of pyruvic acid (methyl pyruvate) stimulated a dose-dependent increase in insulin secretion from isolated perifused rat islets. The threshold level for release was about 10 mM, and at 20 mM the addition of MP to perifused islets resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eccb1cb997c5c2a91a48418369cdb1fd
https://pubmed.ncbi.nlm.nih.gov/9013600

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