Zobrazeno 1 - 10
of 14
pro vyhledávání: '"K. C. Garcia"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 1, Pp 54-55 (2017)
OBJECTIVES/SPECIFIC AIMS: The off-target and organ-specific toxicities observed in cancer immunotherapy present an obstacle to T-cell-based therapeutics. A recent clinical trial underscored the need for improved methods to define TCR specificity afte
Externí odkaz:
https://doaj.org/article/5404e624db344f1daf052100843d6344
Autor:
John Janetzko, Ryoji Kise, Benjamin Barsi‐Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. C. Garcia, Mark Zastrow, Asuka Inoue, Brian K. Kobilka
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61af36971992f108e0a5ac3ee1f54248
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
Publikováno v:
Thrombosis and Haemostasis. 87:294-299
SummaryThe molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf0d656dc3dfc2cda57db278620e67b
https://doi.org/10.1055/s-0037-1612988
https://doi.org/10.1055/s-0037-1612988
Publikováno v:
Protein Science. 7:413-418
Class II Major Histocompatibility (MHC) molecules are cell surface heterodimeric glycoproteins that play a central role in the immune response by presenting peptide antigens for surveillance by T cells. Due to the inherent instability of the class II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f0d7094743b3f31ff520718c2d2dc81
https://doi.org/10.1002/pro.5560070222
https://doi.org/10.1002/pro.5560070222
Publikováno v:
Thrombosis and haemostasis. 87(2)
The molecular basis of Factor V deficiency has been defined in few patients only. We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. This substitution results in the replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adf5478c68677d278487f8bab1ca38bd
https://pubmed.ncbi.nlm.nih.gov/11858490
https://pubmed.ncbi.nlm.nih.gov/11858490
Publikováno v:
Reviews in immunogenetics. 1(1)
The structural basis of antigen recognition in cellular immunity has been elucidated through the determination of crystal structures of major histocompatibility complex (MHC) molecules bound to antigenic peptides, T cell receptors (TCR), CD8 and CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c60c7bc3920ad1e66bca329c6bf99e7
https://pubmed.ncbi.nlm.nih.gov/11256574
https://pubmed.ncbi.nlm.nih.gov/11256574
Autor:
K. D. C. Jensen, J. Wienands, A. Shibuya, H. Bohnenberger, H. Kikutani, P. Marrack, E. W. Newell, E. Huseby, S. Tahara-Hanaoka, N. Totsuka, K. Kometani, C. Nakahashi-Oda, J. Scott-Browne, M. S. Kuhns, Kenji Shibuya, N. Anikeeva, K. Dittmann, M. Tokunaga, M. M. Kessels, Y. Sykulev, V. Bremes, J. Kappler, J. B. Huppa, M. L. Dustin, B. F. Lillemeier, K. Rubtsova, M. Hikida, T. Yasui, M. M. Davis, T. Oellerich, F. Wan, H. Hsiao, S. Dai, F. Crawford, M. Engelke, T. Kurosaki, T. Nakano, T. Bock, T. O. Cameron, M. Kadosaki, A. T. Girvin, L. L. Lanier, L. Yin, A. Beal, R. Chen, L. O. Klein, Y. Chien, P. J. Norris, N. Martínez-Martín, K. Sakata-Sogawa, B. Qualmann, T. Saito, K. Neumann, H. Urlaub, T. Yokosuka, T. Yamada, K. C. Garcia, W. W. A. Schamel, E. P. Dopfer, M. Huse, S. Minguet, B. Wollscheid, B. Alarcón, M. J. Lenardo, R. Varma
Publikováno v:
International Immunology. 22:i39-i40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e87f7f33c211df6c3a39cceae8f380
https://doi.org/10.1093/intimm/dxq159
https://doi.org/10.1093/intimm/dxq159
Publikováno v:
Annual review of immunology. 17
▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural basis of cellular immune recognition. Crystal structures have been determined for full-length and truncated forms of αβ T cell receptor (TCR) heterodim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7a93e23cab247fd344e8e1a17fcdc7
https://pubmed.ncbi.nlm.nih.gov/10358763
https://pubmed.ncbi.nlm.nih.gov/10358763
Autor:
Ian A. Wilson, Anders Brunmark, Luc Teyton, Francis R. Carbone, Per A. Peterson, C.A. Scott, K C Garcia
Publikováno v:
Nature. 384(6609)
T-cell antigen receptors (TCR) generally interact with moderate affinity with the complex formed by major histocompatibility complex (MHC) molecules and foreign peptides. MHC/TCR recognition is followed by the generation of a signal to the T cell thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81198c9a75a6f60c1c12a4402cbedb1
https://pubmed.ncbi.nlm.nih.gov/8955266
https://pubmed.ncbi.nlm.nih.gov/8955266
Publikováno v:
The Journal of Experimental Medicine
Structural studies of cellular receptor molecules involved in immune recognition require the production of large quantities of the extracellular domains of these glycoproteins. The murine major histocompatibility complex (MHC) class II-restricted res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd50df37a403b5c2274a4b6420d338f6
https://pubmed.ncbi.nlm.nih.gov/8642319
https://pubmed.ncbi.nlm.nih.gov/8642319