Zobrazeno 1 - 10
of 26
pro vyhledávání: '"K. C. Cundy"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 48:120-128
UNLABELLED Gabapentin enacarbil, an actively transported prodrug of gabapentin, provides sustained and dose-proportional exposure to gabapentin. OBJECTIVE To evaluate the effect of food of varying fat content on the pharmacokinetics and tolerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c87db4d52d330cd396ce229a6a0bfb
https://doi.org/10.5414/cpp48120
https://doi.org/10.5414/cpp48120
Autor:
M. N. Arimilli, J. P. Shaw, R. Oliyai, Choung U. Kim, K. C. Cundy, A. Mulato, J. Dougherty, N. Bischofberger
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:557-564
Potentially orally bioavailable prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated. Alkyl methyl carbamates were synthesized by alkylation of PMPA with the corresponding alkyl chloromethyl carbonate and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e68a6effe6683ad11d9e7d4f958a75
https://doi.org/10.1177/095632029700800610
https://doi.org/10.1177/095632029700800610
Publikováno v:
Alimentary pharmacologytherapeutics. 38(2)
Summary Background Arbaclofen placarbil is a pro-drug of the gamma-aminobutyric acid-B agonist R-baclofen that has been shown to reduce reflux episodes in patients with gastro-oesophageal reflux disease (GERD). Aim To evaluate the efficacy and safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7adc601492745419e29b39a65603db
https://pubmed.ncbi.nlm.nih.gov/23721547
https://pubmed.ncbi.nlm.nih.gov/23721547
Autor:
S A Lacy, M S Chen, Z H Li, K M Kent, William A. Lee, N Bischofberger, Dirk B. Mendel, K C Cundy, Michael J. M. Hitchcock, D.B. Barkhimer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:2387-2391
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosi ne (cyclic [cHPMPC]) was evaluated as a novel antiviral agent in comparison with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC). Evaluation for in vitro activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5a4d4defc1c8e2dfc309f52d53a729
https://doi.org/10.1128/aac.38.10.2387
https://doi.org/10.1128/aac.38.10.2387
Publikováno v:
International journal of clinical pharmacology and therapeutics. 49(2)
UNLABELLED Gabapentin enacarbil (GEn) is a prodrug of gabapentin that is effective in restless legs syndrome (RLS) and has dose-proportional gabapentin exposure. OBJECTIVE This Phase I, open-label, non-randomized, single-center study of 14C-GEn in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ed7c211a2e0c787ff331cd038d0659
https://pubmed.ncbi.nlm.nih.gov/21255527
https://pubmed.ncbi.nlm.nih.gov/21255527
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
The metabolism of [2-acetyl-(14)C]oseltamivir (GS4104, Ro 64-0796), the prodrug of the novel influenza neuraminidase inhibitor GS4071 (Ro 64-0802), was examined in rats after oral dosing. Intact oseltamivir was observed only in lung and urine, accoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::189afc7ac7f8de7e0e1fc3d264da1ea7
https://pubmed.ncbi.nlm.nih.gov/10859145
https://pubmed.ncbi.nlm.nih.gov/10859145
Publikováno v:
Pharmaceutical research. 16(11)
The chemical, enzymatic, and biological stabilities and physical properties of a series of salicylate and aryl ester prodrugs of the antiviral agent, cyclic HPMPC, were evaluated to support the selection of a lead compound for clinical development.Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9d36370ce783346408ef67c9e7a8d84
https://pubmed.ncbi.nlm.nih.gov/10571273
https://pubmed.ncbi.nlm.nih.gov/10571273
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 44(2)
In animals and humans, intravenous administration of the antiviral nucleotide analogue cidofovir results in a dose-limiting nephrotoxicity characterized by damage to the proximal tubular epithelial cells. Probenecid, a competitive inhibitor of organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4c6087c7de17d1013df3c3807ec04f0
https://pubmed.ncbi.nlm.nih.gov/9742650
https://pubmed.ncbi.nlm.nih.gov/9742650
Publikováno v:
Pharmaceutical research. 14(12)
A series of prodrugs designed to enhance the oral bioavailability of the antiretroviral agent 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA; 1) have been synthesized, including a bis-(acyloxymethyl) ester 2 and a series of bis-(alkoxycarbonyloxymet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d18324ef72e7fd0f716dad948303bc84
https://pubmed.ncbi.nlm.nih.gov/9453075
https://pubmed.ncbi.nlm.nih.gov/9453075
Autor:
J P, Shaw, M S, Louie, V V, Krishnamurthy, M N, Arimilli, R J, Jones, A M, Bidgood, W A, Lee, K C, Cundy
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(3)
The oral bioavailability of PMEA [9-[2-(phosphonomethoxy)ethyl]adenine; adefovir) has been determined in rats from three bisester prodrugs of PMEA: bis-(pivaloyloxymethyl) PMEA (bis-POM PMEA), bis-(phenyl) PMEA, and bis-(o-ethoxyphenyl) PMEA. The pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe4f5571ab317a5f44834eef50547654
https://pubmed.ncbi.nlm.nih.gov/9172955
https://pubmed.ncbi.nlm.nih.gov/9172955