Zobrazeno 1 - 10
of 3 309
pro vyhledávání: '"K. Burley"'
Autor:
Alexander M. Ille, Christopher Markosian, Stephen K. Burley, Michael B. Mathews, Renata Pasqualini, Wadih Arap
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural langu
Externí odkaz:
https://doaj.org/article/10e11cbd36b74d4f8c9029d6d1ab1092
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 279-286 (2024)
The Protein Data Bank (PDB) was established as the first open-access digital data resource in biology and medicine in 1971 with seven X-ray crystal structures of proteins. Today, the PDB houses >210 000 experimentally determined, atomic level, 3D str
Externí odkaz:
https://doaj.org/article/0cd7c7d944c8444f884de5367ef41ad1
Autor:
Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, m
Externí odkaz:
https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f
Publikováno v:
Cells, Vol 13, Iss 9, p 781 (2024)
mTOR is a central regulator of cell growth and metabolism in response to mitogenic and nutrient signals. Notably, mTOR is not only found in the cytoplasm but also in the nucleus. This review highlights direct involvement of nuclear mTOR in regulating
Externí odkaz:
https://doaj.org/article/286c1943e93444e3b0aac12debb6cdea
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2023)
Recent advances in Artificial Intelligence and Machine Learning (e.g., AlphaFold, RosettaFold, and ESMFold) enable prediction of three-dimensional (3D) protein structures from amino acid sequences alone at accuracies comparable to lower-resolution ex
Externí odkaz:
https://doaj.org/article/996e6411879c41209af17a862968a3cb
Autor:
Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Minh T. Ma, Chih-Hsiung Chen, Dongfang Liu, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Given the COVID-19 pandemic, there is interest in understanding ligand-receptor features and targeted antibody-binding attributes against emerging SARS-CoV-2 variants. Here, we developed a large-scale structure-based pipeline for analysis of protein-
Externí odkaz:
https://doaj.org/article/dc31889fa8f7403f837661ab04c09d04
Autor:
Abrate, Mario
Publikováno v:
Giornale degli Economisti e Annali di Economia, 1969 May 01. 28(5/6), 406-407.
Externí odkaz:
https://www.jstor.org/stable/23240996
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151240- (2022)
Amino Acids are not only major nutrient sources, but also serve as chemical signals to control cellular growth. Rab1A recently emerged as a key component in amino acid sensing and signaling to activate the mTOR complex1 (mTORC1). In a recently publis
Externí odkaz:
https://doaj.org/article/6af013365df4401ea04ecc4c65120049
Autor:
Stephen K. Burley, Helen M. Berman, Jose M. Duarte, Zukang Feng, Justin W. Flatt, Brian P. Hudson, Robert Lowe, Ezra Peisach, Dennis W. Piehl, Yana Rose, Andrej Sali, Monica Sekharan, Chenghua Shao, Brinda Vallat, Maria Voigt, John D. Westbrook, Jasmine Y. Young, Christine Zardecki
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1425 (2022)
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), funded by the United States National Science Foundation, National Institutes of Health, and Department of Energy, supports structural biologists and Protein Data B
Externí odkaz:
https://doaj.org/article/670753c24cbc4a07a6bf385727b5f6ef
Autor:
Fernanda I Staquicini, Amin Hajitou, Wouter HP Driessen, Bettina Proneth, Marina Cardó-Vila, Daniela I Staquicini, Christopher Markosian, Maria Hoh, Mauro Cortez, Anupama Hooda-Nehra, Mohammed Jaloudi, Israel T Silva, Jaqueline Buttura, Diana N Nunes, Emmanuel Dias-Neto, Bedrich Eckhardt, Javier Ruiz-Ramírez, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Martin Trepel, Robin Anderson, Richard L Sidman, Juri G Gelovani, Massimo Cristofanilli, Gabriel N Hortobagyi, Zaver M Bhujwalla, Stephen K Burley, Wadih Arap, Renata Pasqualini
Publikováno v:
eLife, Vol 10 (2021)
Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a
Externí odkaz:
https://doaj.org/article/2b69063fcd2842da978005193781ce00