Zobrazeno 1 - 10
of 234
pro vyhledávání: '"K. Burks"'
Autor:
Bofei Wang, Patrick K. Reville, Mhd Yousuf Yassouf, Fatima Z. Jelloul, Christopher Ly, Poonam N. Desai, Zhe Wang, Pamella Borges, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Araceli Isabella Garza, Cedric Nasnas, Nicole R. Vaughn, Natalia Baran, Qing Deng, Jairo Matthews, Preethi H. Gunaratne, Dinler A. Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Konopleva, Andrew Futreal, Sean M. Post, Hussein A. Abbas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated in sera of most newly diagnosed acute myeloid leukemia (AML) pa
Externí odkaz:
https://doaj.org/article/03859817a55c485c9cfde6439e811923
Autor:
Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Qi Wang, Ximing Tang, Sen Pathak, Maria Gabriela Raso, Jared K. Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 (mutp53) proteins which promotes tumor development and progression. The GOF activities of TP53 mutati
Externí odkaz:
https://doaj.org/article/439599fe4b0841cea0b2d92022192f6d
Autor:
Hinda Najem, Sebastian Pacheco, Joanna Kowal, Dan Winkowski, Jared K. Burks, Amy B. Heimberger
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103079- (2024)
Summary: Although myeloid-derived immune cells can be dispersed throughout the tumor microenvironment (TME), anti-tumor effector cells are confined to the perivascular space. Here, we present a protocol to quantify immune cell distribution from tumor
Externí odkaz:
https://doaj.org/article/baf06e8319234ab6b7e144beab5706b1
Autor:
Omar A. Saldarriaga, Timothy G. Wanninger, Esteban Arroyave, Joseph Gosnell, Santhoshi Krishnan, Morgan Oneka, Daniel Bao, Daniel E. Millian, Michael L. Kueht, Akshata Moghe, Jingjing Jiao, Jessica I. Sanchez, Heidi Spratt, Laura Beretta, Arvind Rao, Jared K. Burks, Heather L. Stevenson
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100958- (2024)
Background & Aims: Clinical trials for reducing fibrosis in steatotic liver disease (SLD) have targeted macrophages with variable results. We evaluated intrahepatic macrophages in patients with SLD to determine if activity scores or fibrosis stages i
Externí odkaz:
https://doaj.org/article/805528696642459d8879b49285c2e45a
Autor:
Rasoul Pourebrahim, Rafael Heinz Montoya, Zoe Alaniz, Lauren Ostermann, Patrick P. Lin, Bin Liu, Edward Ayoub, Jared K. Burks, Michael Andreeff
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-11 (2023)
Abstract Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for the maintenance of hematopoietic stem cells. To advance our understanding of physiological functions of p53 and Mdm2
Externí odkaz:
https://doaj.org/article/1df39bffb885489bae594c472f52fdc8
Autor:
Adi Diab, Suhendan Ekmekcioglu, Noha Abdel-Wahab, Michael A Davies, Julie M Simon, Alexander J Lazar, Jared K Burks, Salah-Eddine Bentebibel, Sungnam Cho, Javier A Gomez, Reham Abdel-Wahab, Jeffrey E Gershenwald
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/031bb837235f4699a6d86f0f37e8c063
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, ICB alone has demonstrated only benefit in a small subset of patients with breast cancer. Recent studies have shown that agents targeting DNA damage response im
Externí odkaz:
https://doaj.org/article/be2b5cd1dc7440f9bbb2a9d0b36d9eb7
Autor:
Moran Amit, Tongxin Xie, Frederico O. Gleber-Netto, Patrick J. Hunt, Gautam U. Mehta, Diana Bell, Deborah A. Silverman, Ismail Yaman, Yi Ye, Jared K. Burks, Gregory N. Fuller, Paul W. Gidley, Marc-Elie Nader, Shaan M. Raza, Franco DeMonte
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022)
Abstract Background The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease’s variable progression rate. We
Externí odkaz:
https://doaj.org/article/cb19f57deac94742b61784c0d5040f00
Autor:
Yasunari Fukuda, Matias A. Bustos, Sung-Nam Cho, Jason Roszik, Suyeon Ryu, Victor M. Lopez, Jared K. Burks, Jeffrey E. Lee, Elizabeth A. Grimm, Dave S. B. Hoon, Suhendan Ekmekcioglu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Abstract Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. Soluble CD74 (sCD74) has been identified in sera of inflammatory diseases and implicated in their pathophysiology; however, few relevant data are a
Externí odkaz:
https://doaj.org/article/140d1bf9c59b46fe8fac11763cb01977
Autor:
Ya’an Kang, Jenying Deng, Jianhua Ling, Xinqun Li, Yi-Ju Chiang, Eugene J. Koay, Huamin Wang, Jared K. Burks, Paul J. Chiao, Mark W. Hurd, Manoop S. Bhutani, Jeffrey H. Lee, Brian R. Weston, Anirban Maitra, Naruhiko Ikoma, Ching-Wei D. Tzeng, Jeffrey E. Lee, Ronald A. DePinho, Robert A. Wolff, Shubham Pant, Florencia McAllister, Matthew H.G. Katz, Jason B. Fleming, Michael P. Kim
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with unpredictable responses to chemotherapy. Approaches to assay patient tumors before treatment and identify effective treatment regimens based on tumor sens
Externí odkaz:
https://doaj.org/article/79511496d0394ed69402ac29b6420cc6