Zobrazeno 1 - 10
of 151
pro vyhledávání: '"K. Brubaker"'
Autor:
Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman Bechtel, Elizabeth A. Proctor, Douglas K. Brubaker
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Type 2 diabetes (T2D) is implicated as a risk factor for Alzheimer’s disease (AD), the most common form of dementia. In this work, we investigated neuroinflammatory responses of primary neurons to potentially circulating, blood–brain bar
Externí odkaz:
https://doaj.org/article/498556b271e04785836d3c46ad056781
Autor:
Ran Ran, Javier Muñoz Briones, Smrutiti Jena, Nicole L. Anderson, Matthew R. Olson, Leopold N. Green, Douglas K. Brubaker
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109383- (2024)
Summary: The co-culture of two adult human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an in vitro gut mimic, yet the translatability of insights from such a system to adult human physiological contexts is not full
Externí odkaz:
https://doaj.org/article/f1236eabc5364a3ba232ca68f709454f
Autor:
Alicia R. Berard, Douglas K. Brubaker, Kenzie Birse, Alana Lamont, Romel D. Mackelprang, Laura Noël-Romas, Michelle Perner, Xuanlin Hou, Elizabeth Irungu, Nelly Mugo, Samantha Knodel, Timothy R. Muwonge, Elly Katabira, Sean M. Hughes, Claire Levy, Fernanda L. Calienes, Douglas A. Lauffenburger, Jared M. Baeten, Connie Celum, Florian Hladik, Jairam Lingappa, Adam D. Burgener
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112474- (2023)
Summary: Bacterial vaginosis (BV) is characterized by depletion of Lactobacillus and overgrowth of anaerobic and facultative bacteria, leading to increased mucosal inflammation, epithelial disruption, and poor reproductive health outcomes. However, t
Externí odkaz:
https://doaj.org/article/7e7c96530b7143479c58b3f44a85ad62
Autor:
Meghana Pendyala, Paige S Woods, Douglas K Brubaker, Elizabeth A Blaber, Tannin A Schmidt, Deva D Chan
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0267921 (2022)
Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovia
Externí odkaz:
https://doaj.org/article/9ed021c9513346fa8cc93e2a5519aa2d
Autor:
Lucia Suarez-Lopez, Bing Shui, Douglas K. Brubaker, Marza Hill, Alexander Bergendorf, Paul S. Changelian, Aisha Laguna, Alina Starchenko, Douglas A. Lauffenburger, Kevin M. Haigis
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103406- (2021)
Summary: Inflammatory bowel diseases (IBDs) are genetically complex and exhibit significant inter-patient heterogeneity in disease presentation and therapeutic response. Here, we show that mouse models of IBD exhibit variable responses to inhibition
Externí odkaz:
https://doaj.org/article/76c5639d0d49434cae5abe91c97fbaf5
Autor:
Meelim J. Lee, Chuangqi Wang, Molly J. Carroll, Douglas K. Brubaker, Bradley T. Hyman, Douglas A. Lauffenburger
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Mouse models are vital for preclinical research on Alzheimer’s disease (AD) pathobiology. Many traditional models are driven by autosomal dominant mutations identified from early onset AD genetics whereas late onset and sporadic forms of the diseas
Externí odkaz:
https://doaj.org/article/1a46203826334ebf9af29595514b0f95
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006286 (2019)
The high failure rate of therapeutics showing promise in mouse models to translate to patients is a pressing challenge in biomedical science. Though retrospective studies have examined the fidelity of mouse models to their respective human conditions
Externí odkaz:
https://doaj.org/article/29393369000446f9be89f2d2bb3783d7
Autor:
Ran Ran, Douglas K. Brubaker
T cell heterogeneity presents a challenge for accurate cell identification, understanding their inherent plasticity, and characterizing their critical role in adaptive immunity. Immunologists have traditionally employed techniques such as flow cytome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e6f1c14eb3c2a451bc13af43e320294
https://doi.org/10.1101/2023.05.23.541821
https://doi.org/10.1101/2023.05.23.541821
The gut plays a critical role in maintaining human health by facilitating the absorption of nutrients, regulating metabolism, and interacting with the immune system and gut microbiota. The co-culture of two human colorectal cancer cell lines, Caco-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d740d05502681fcaa3317ecd1d5297f2
https://doi.org/10.1101/2023.05.23.541940
https://doi.org/10.1101/2023.05.23.541940
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
GSEA analysis of spleens expressing WT or mutant K-Ras.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8e1f7c6030d1ab255c13f4cf34cb1e
https://doi.org/10.1158/2159-8290.22532593
https://doi.org/10.1158/2159-8290.22532593