Zobrazeno 1 - 10 of 223 pro vyhledávání: '"K. Beach"'
1
Akademický článek
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors
Autor: Daria Ostroverkhova, Kathrin Tyryshkin, Annette K. Beach, Elizabeth A. Moore, Yosef Masoudi-Sobhanzadeh, Stephanie R. Barbari, Igor B. Rogozin, Konstantin V. Shaitan, Anna R. Panchenko, Polina V. Shcherbakova
Publikováno v: Cell Reports, Vol 43, Iss 1, Pp 113655- (2024)
Summary: Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers. These cancers accumulate AGA>ATA transversions; however, their genomic features beyond the trinucleotide motifs are obscure. We analyze the extended DNA c
Externí odkaz: https://doaj.org/article/e3c6568d61ee42b79709d60182e96c2f
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3
Akademický článek
Exploring the Meta-regulon of the CRP/FNR Family of Global Transcriptional Regulators in a Partial-Nitritation Anammox Microbiome
Autor: Natalie K. Beach, Kevin S. Myers, Brian R. Owen, Matt Seib, Timothy J. Donohue, Daniel R. Noguera
Publikováno v: mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Microorganisms must respond to environmental changes to survive, often by controlling transcription initiation. Intermittent aeration during wastewater treatment presents a cyclically changing environment to which microorganisms must react.
Externí odkaz: https://doaj.org/article/8c96749778e14349a77d2757fe5c5c1c
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5
Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels
Autor: Stephanie R Barbari, Annette K Beach, Joel G Markgren, Vimal Parkash, Elizabeth A Moore, Erik Johansson, Polina V Shcherbakova
Publikováno v: Nucleic Acids Research. 50:8023-8040
Amino acid substitutions in the exonuclease domain of DNA polymerase ϵ (Polϵ) cause ultramutated tumors. Studies in model organisms suggested pathogenic mechanisms distinct from a simple loss of exonuclease. These mechanisms remain unclear for most
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2dc73bd5a837c870031d9aaa0023ac
https://doi.org/10.1093/nar/gkac602
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6
Akademický článek
Design and Assessment of Species-Level qPCR Primers Targeting Comammox
Autor: Natalie K. Beach, Daniel R. Noguera
Publikováno v: Frontiers in Microbiology, Vol 10 (2019)
Published PCR primers targeting the ammonia monooxygenase gene (amoA) were applied to samples from activated sludge systems operated with low dissolved oxygen (DO) to quantify total and clade-level Nitrospira that perform complete ammonium oxidation
Externí odkaz: https://doaj.org/article/0383d428bd114198a785d48b828835f4
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7
Complete Genome Sequences and Characteristics of Seven Novel Mycobacteriophages
Autor: Skylar M Weiss, Kezia K Happy, Faith W Baliraine, Abigail K Beach, Sean M Brobston, Claire P Martinez, Kaitlyn J Menard, Savannah M Orton, Angela L Salazar, Gregory D Frederick, Frederick N Baliraine
Full genome sequences of seven mycobacteriophages isolated from environmental soil samples are presented. These bacteriophages, with their respective cluster or subclusters, are Duplo (A2), Dynamo (P1), Gilberta (A11), MaCh (A11), Nikao (K1), Phloss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14595c427fcf96c9377ac23d94cd9b67
https://doi.org/10.1101/2023.04.18.537415
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8
Akademický článek
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