Výsledky vyhledávání - "K. B. Bouker"

A phase I trial of a Bcl-2 antisense (G3139) and weekly docetaxel in patients with advanced breast cancer and other solid tumors

Autor: K. B. Bouker, Y. Ling, Da-Jun Yang, Daniel F. Hayes, John L. Marshall, S. R. Frankel, M. Figueira, Marc E. Lippman, H. Chen

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 15(8)

Purpose: Expression of the Bcl-2 protein confers resistance to various apoptotic signals. G3139 [oblimersen sodium (Genasense™)] is a phosphorothioate antisense oligodeoxynucleotide that targets Bcl-2 mRNA, downregulates Bcl-2 protein translation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3fa3157f31f1d241c1f1d03c3779a8
https://pubmed.ncbi.nlm.nih.gov/15277270

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