Zobrazeno 1 - 10
of 46
pro vyhledávání: '"K. Asou"'
Autor:
Toshio Kanno, Ryo Konno, Masaru Sato, Atsushi Kurabayashi, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Junichiro Ohzeki, Yoshinori Hasegawa, Kazutaka Ikeda, Yusuke Kawashima, Osamu Ohara, Yusuke Endo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Recent studies have highlighted the significance of cellular metabolism in the initiation of clonal expansion and effector differentiation of T cells. Upon exposure to antigens, naïve CD4+ T cells undergo metabolic reprogramming to meet the
Externí odkaz:
https://doaj.org/article/299bfaa138b64b138aeb89989a2a7fb0
Autor:
Toshio Kanno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Type I interferons (type I-IFN) are critical for the host defense to viral infection, and at the same time, the dysregulation of type I-IFN responses leads to autoinflammation or autoimmunity. Recently, we reported that the decrease in monounsaturate
Externí odkaz:
https://doaj.org/article/2923add3c011494e95752618bc6c2500
Autor:
Toshio Kanno, Takahiro Nakajima, Satoru Yokoyama, Hikari K. Asou, Shigemi Sasamoto, Yasuhiro Kamii, Koji Hayashizaki, Yasuo Ouchi, Taishi Onodera, Yoshimasa Takahashi, Kazutaka Ikeda, Yoshinori Hasegawa, Yuki Kinjo, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Kanno et al. demonstrate that decreased monounsaturated fatty acid in CD4 + T cells following Scd2 deletion boosts the induction of the antiviral response via activation of the cGAS-STING pathway in mice. This study highlights the important interacti
Externí odkaz:
https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea
Autor:
Takeshi Yamamoto, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Hikari K. Asou, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Satoshi Uematsu, Hiroshi Nishimasu, Osamu Nureki, Damon J. Tumes, Naoki Shimojo, Toshinori Nakayama
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3
Externí odkaz:
https://doaj.org/article/2fa4e1b6bbf74a90bf17ce9936a84fec
Autor:
Mulki Angela, Yusuke Endo, Hikari K. Asou, Takeshi Yamamoto, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.
Externí odkaz:
https://doaj.org/article/872f8a9911d2463e957bee8d463e00e8
Autor:
Yusuke Endo, Hikari K. Asou, Nao Matsugae, Kiyoshi Hirahara, Kenta Shinoda, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Publikováno v:
Cell Reports, Vol 12, Iss 6, Pp 1042-1055 (2015)
Chronic inflammation due to obesity contributes to the development of metabolic diseases, autoimmune diseases, and cancer. Reciprocal interactions between metabolic systems and immune cells have pivotal roles in the pathogenesis of obesity-associated
Externí odkaz:
https://doaj.org/article/94e966b18a0b4960a81154bd27e87a59
Autor:
Toshio Kanno, Ryo Konno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K Asou, Junichiro Ohzeki, Yusuke Kawashima, Yoshinori Hasegawa, Osamu Ohara, Yusuke Endo
Publikováno v:
DNA research : an international journal for rapid publication of reports on genes and genomes.
Functionally distinct CD4+ helper T (Th) cell subsets, including Th1, Th2, Th17, and regulatory T cells (Treg), play a pivotal role in the regulation of acquired immunity. Although the key proteins involved in the regulation of Th cell differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c558558a6c6f3126ed6e45aac969bb
https://pubmed.ncbi.nlm.nih.gov/36579714
https://pubmed.ncbi.nlm.nih.gov/36579714
Autor:
Yuki Kinjo, Osamu Ohara, Koji Hayashizaki, Yoshinori Hasegawa, Yoshimasa Takahashi, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Taishi Onodera, Yasuhiro Kamii, Kazutaka Ikeda, Shigemi Sasamoto, Satoru Yokoyama, Yusuke Endo, Hikari K. Asou, Toshinori Nakayama
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Host lipid metabolism and viral responses are intimately connected. However, the process by which the acquired immune systems adapts lipid metabolism to meet demands, and whether or not the metabolic rewiring confers a selective advantage to host imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bcb081a2dd251ab8e8771a01527014
https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea
https://doaj.org/article/5ddb20f26de643ee84cf7f21c6c28eea
Akademický článek
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ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice
Autor:
Satoru Yokoyama, Damon J. Tumes, Toshio Kanno, Hikari K. Asou, Shigemi Sasamoto, Yusuke Endo, Toshinori Nakayama, Osamu Ohara, Takahiro Nakajima
Publikováno v:
The Journal of experimental medicine. 218(12)
T cells possess distinguishing effector functions and drive inflammatory disorders. We have previously identified IL-5–producing Th2 cells as the pathogenic population predominantly involved in the pathology of allergic inflammation. However, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f94699d81c4861e43864e18d2ba2f00
https://pubmed.ncbi.nlm.nih.gov/34813654
https://pubmed.ncbi.nlm.nih.gov/34813654