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Akademický článek

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Real-world use of G-CSF in patients with breast cancer during first wave of COVID-19 in Germany

Autor: K. Apel, N. Güneli, J. Borchardt, F. Losch, B. Peetroons

Publikováno v: Senologie - Zeitschrift für Mammadiagnostik und -therapie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a3af4f6425f68b94e63ac124c93607
https://doi.org/10.1055/s-0042-1748342

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Drug-Induced Liver Injury – Stellenwert der Pathologie

Autor: A Canbay, K Apel, K Pütz, Y Tolkach, Uta Drebber

Publikováno v: Der Pathologe. 41:457-470

Zahlreiche unterschiedliche Substanzen wie Medikamente, Heilkrauter, Nahrungserganzungsmittel konnen einen toxischen Leberparenchymschaden induzieren im Sinne einer klinisch relevanten Komplikation. Die Drug-Induced Liver Injury (DILI), welche auf ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70d49951e1e42ae31a6e73eb835fadc6
https://doi.org/10.1007/s00292-020-00811-x

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Akademický článek

Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.

Autor: Katrin Flinspach, Claudia Kapitzke, Arianna Tocchetti, Margherita Sosio, Alexander K Apel

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90499 (2014)

GE2270 is a thiopeptide antibiotic generated by extensive posttranslational modifications of a ribosomally generated precursor peptide. Thiopeptides are especially active against Gram-positive bacteria, including methicillin resistant Staphylococcus

Externí odkaz: https://doaj.org/article/572910af41d147d0adcaa4d341a6d106

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[Drug-induced liver injury-significance of pathology]

Autor: K, Apel, K, Pütz, Y, Tolkach, A, Canbay, U, Drebber

Publikováno v: Der Pathologe. 41(5)

Many different medical agents, herbal products, and dietary supplements can induce drug-induced liver injury (DILI) as a clinically relevant complication. DILI, which is direct toxic or idiosyncratic, can have a broad spectrum of clinical appearances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8408b7e84b2e37ca957f57a0f2cfb261
https://pubmed.ncbi.nlm.nih.gov/32813127

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Small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia

Autor: Markus Blankenburg, T. Reindl, K. Apel, Sascha Lieber, G. Hirschfeld, P. Hernáiz Driever

Publikováno v: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 22(3)

Background Chemotherapy-induced Peripheral Neuropathy (CIPN) of large-fibers affects up to 20% of survivors of pediatric acute lymphoblastic leukemia (ALL). We aimed to describe small-fiber toxicity and pain sensitization in this group. Methods In a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a8c5ebebf9306630d5cda11b977190
https://pubmed.ncbi.nlm.nih.gov/29396168

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Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion

Autor: M.C. Cox, T. Holl, K. Simon-Klingenstein, R. Tupper, S. Ortega-Lawerenz, R. Jenewein, Michaela Nathrath, M. Reynolds, Christian Vokuhl, U. Klenk, Peter Müller-Abt, C. Blattmann, Sabine Stegmaier, P. Klothaki, M. Scheer, Stefan S. Bielack, T. von Kalle, K. Apel

Publikováno v: Annals of Oncology

Background The ETV6-NTRK3 gene fusion is present in the majority of cases of infantile fibrosarcoma (IFS) and acts as a potent oncogenic driver. We report the very rapid, complete, and sustained response of an advanced, chemotherapy-refractory, recur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a2aa46b9505409ec9580f44bfad089
https://doi.org/10.1093/annonc/mdz382

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Quantitative Sensory Testing Is Highly Sensitive in Detecting Chemotherapy-Induced Peripheral Neuropathy

Autor: Driever P. Hernáiz, Markus Blankenburg, T. Reindl, K. Apel, Sascha Lieber

Publikováno v: Neuropediatrics. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aff29d49eac14383695c3758e25328f5
https://doi.org/10.1055/s-0036-1583708

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Challenges in the Heterologous Production of Antibiotics in Streptomyces

Autor: Paulina, Bekiesch, Patrick, Basitta, Alexander K, Apel

Publikováno v: Archiv der Pharmazie. 349(8)

The fast growing genome databases provide us with a large number of so far unknown secondary metabolite biosynthetic gene clusters. A key method to study these gene clusters is their heterologous expression in an engineered host strain. Gene clusters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fc6acc67221fab6f93d1eceaa02ec82
https://pubmed.ncbi.nlm.nih.gov/27258165

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