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The Early Course of Kidney Allograft Rejection: Defining the Time When Rejection Begins

Autor: Gunilla Einecke, K. Allanach, Michael Mengel, Konrad S. Famulski, Philip F. Halloran, Luis G. Hidalgo

Publikováno v: American Journal of Transplantation. 9:483-493

We studied the early events in mouse kidney allografts and isografts to define when allorecognition begins and when alloimmune tissue injury begins. Allografts but not isografts showed T-cell infiltration in perivascular areas from day 1, but tubulit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b5dd0db094621ee85363725227fe75
https://doi.org/10.1111/j.1600-6143.2008.02546.x

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The Transcriptome of Human Cytotoxic T Cells: Similarities and Disparities Among Allostimulated CD4+ CTL, CD8+ CTL and NK cells

Autor: L. G. Hidalgo, Gunilla Einecke, K. Allanach, Philip F. Halloran

Publikováno v: American Journal of Transplantation. 8:627-636

Transcripts expressed in cytotoxic T lymphocytes (CTL) have mechanistic and diagnostic importance in transplantation. We used microarrays to select CTL-associated transcripts (CATs) expressed in human CD4(+) CTL, CD8(+) CTL and NK cells, excluding tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14a9dd686d70532f82a072be16ebb97
https://doi.org/10.1111/j.1600-6143.2007.02128.x

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IFN‐γ Prevents Early Perforin‐Granzyme‐Mediated Destruction of Kidney Allografts by Inducing Donor Class I Products in the Kidney

Autor: Lin-Fu Zhu, Konrad S. Famulski, Banu Sis, K. Allanach, P. F. Halloran

Publikováno v: American Journal of Transplantation. 7:2301-2310

Interferon-gamma (Ifng) protects organ allografts: mouse kidney allografts lacking Ifng receptors rapidly fail with massive ischemic necrosis around days 5 to 7, reflecting microcirculation failure. We hypothesized that Ifng protects the graft by pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6b67214bb0adc1b2d7f9ffe2e8acf3
https://doi.org/10.1111/j.1600-6143.2007.01947.x

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Changes in the Transcriptome in Allograft Rejection:IFN-γ-Induced Transcripts in Mouse Kidney Allografts

Autor: Gunilla Einecke, Konrad S. Famulski, P. F. Halloran, K. Allanach, Lin-Fu Zhu, Thomas F. Mueller, Vido Ramassar, Jeff Reeve, Luis G. Hidalgo

Publikováno v: American Journal of Transplantation. 6:1342-1354

We used Affymetrix Microarrays to define interferon-gamma (IFN-gamma)-dependent, rejection-induced transcripts (GRITs) in mouse kidney allografts. The algorithm included inducibility by recombinant IFN-gamma in kidneys of three normal mouse strains,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a816edf3a62c433cb71f3f76c8de5ce
https://doi.org/10.1111/j.1600-6143.2006.01337.x

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FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes

Autor: Gian S. Jhangri, Thomas F. Mueller, Michael Mengel, Philip F. Halloran, K. Allanach, Banu Sis, S. Bunnag, Gunilla Einecke

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 8(7)

Expression of the transcription factor forkhead box P3 (FOXP3) in transplant biopsies is of interest due to its role in a population of regulatory T cells. We analyzed FOXP3 mRNA expression using RT-PCR in 83 renal transplant biopsies for cause in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb987e98928687dfd3884d9d63483e1f
https://pubmed.ncbi.nlm.nih.gov/18557721

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Comparing microarray versus RT-PCR assessment of renal allograft biopsies: similar performance despite different dynamic ranges

Autor: Banu Sis, Gunilla Einecke, Thomas F. Mueller, K. Allanach, Michael Mengel, Philip F. Halloran, Luis G. Hidalgo

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 8(5)

In renal allografts, assessing gene expression can add relevant diagnostic information to histopathology. Results can be expressed as single genes or gene sets, representing pathogenesis-based transcript sets (PBTs): cytotoxic T-cell-associated, inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767c4dec3df39cafaf5910fa5d8b23dc
https://pubmed.ncbi.nlm.nih.gov/18416738

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The transcriptome of human cytotoxic T cells: measuring the burden of CTL-associated transcripts in human kidney transplants

Autor: L. G. Hidalgo, Michael Mengel, K. Allanach, Thomas F. Mueller, Banu Sis, Philip F. Halloran, Gunilla Einecke

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 8(3)

Having defined CTL-associated transcripts (CATs) in CTL in vitro, we used microarrays to quantify the burden of CAT sets compared with individual transcripts in human renal transplant biopsies with T-cell mediated rejection (TCMR). CAT sets in TCMR r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a339ca41375ca5882bdccf5599a2b4
https://pubmed.ncbi.nlm.nih.gov/18294160

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