Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL

Autor: K. A. ten Hoor, Frank A.E. Kruyt, A. Meijer, Geny Groothuis, de Steven Jong, P. Le, Wim J. Quax, Harmen Hollema, de Elisabeth G. E. Vries, van der Ate Zee

Publikováno v: British Journal of Cancer
British Jounal of Cancer, 109(10), 2685-2695. Nature Publishing Group

BACKGROUND: Tumour cell-selective activation of apoptosis by recombinant human TNF-related apoptosis-inducing ligand (rhTRAIL) is enhanced through co-activation of p53 by chemotherapeutic drugs. The novel anticancer agent nutlin-3 provides a promisin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f414294ec48158c6b60aa9cdb6cf825c
https://doi.org/10.1038/bjc.2013.636

Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer

Autor: S de Jong, Toos Daemen, K. A. ten Hoor, Marloes J. M. Gooden, Ninke Leffers, Ute Schulze, Hans W. Nijman, Harmen Hollema, Rudolf S N Fehrmann, van der Aukje Zee, Hendrika Boezen

Publikováno v: British Journal of Cancer
British Jounal of Cancer, 103(5), 685-692. Nature Publishing Group

BACKGROUND: Tumour-infiltrating lymphocytes (TILs) are predictors of disease-specific survival (DSS) in ovarian cancer. It is largely unknown what factors contribute to lymphocyte recruitment. Our aim was to evaluate genes and pathways contributing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc13f4c79038efb3d714eae00e9b340a
https://doi.org/10.1038/sj.bjc.6605820

EGFR expression is associated with groin node metastases in vulvar cancer, but does not improve their prediction

Autor: de Truuske Bock, D. J. van der Veen, van der Ate Zee, K. A. ten Hoor, J.A. de Hullu, Harmen Hollema, M. H. M. Oonk

Publikováno v: Gynecologic Oncology, 104, 109-13
Gynecologic Oncology, 104, 1, pp. 109-13
Gynecologic Oncology, 104(1), 109-113. ACADEMIC PRESS INC ELSEVIER SCIENCE

Objectives. High morbidity of elective inguinofemoral lymphadenectomy in early stage vulvar cancer patients urges the need for defining a group of low-risk patients in whom inguinofemoral lymphadenectomy can be safely omitted. Aim of the study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204d94cb500f6f60de8d42b40b9c21e7
https://research.rug.nl/en/publications/adb22642-544f-485f-81e6-f42db30ee734

The effects of tamoxifen on proliferation and steroid receptor expression in postmenopausal endometrium

Autor: de Elisabeth G. E. Vries, K. A. ten Hoor, Marian J.E. Mourits, Harmen Hollema, Phb Willemse, van der Ate Zee

Publikováno v: Journal of Clinical Pathology. 55:514-519

Aim: To study the effects of tamoxifen on the proliferation index and oestrogen receptor (ER) and progesterone receptor (PR) expression in postmenopausal endometrium. Methods: A total of 125 endometrial specimens of postmenopausal women, comprising b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2639bf9daf505c61a9753a1e0fab91
https://doi.org/10.1136/jcp.55.7.514

Pretreatment serum squamous cell carcinoma antigen: a newly identified prognostic factor in early-stage cervical carcinoma

Autor: K. A. ten Hoor, J.M. Duk, K.H. Groenier, J.G. Aalders, Harry Hollema, A.G.J. van der Zee, H.W.A. de Bruijn

Publikováno v: Journal of Clinical Oncology, 14(1), 111-118. AMER SOC CLINICAL ONCOLOGY

PURPOSE To investigate the prognostic value of pretreatment serum squamous cell carcinoma antigen (SCC-ag) levels in patients with cervical squamous cell carcinoma in relation to well-established conventional risk factors. PATIENTS AND METHODS Sera f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beab89e69927601bc8d63f536f314299
https://doi.org/10.1200/jco.1996.14.1.111