Zobrazeno 1 - 10
of 29
pro vyhledávání: '"K. A. Wafford"'
Autor:
C. M. Holton, N. Hanley, E. Shanks, P. Oxley, A. McCarthy, B. J. Eastwood, T. K. Murray, A. Nickerson, K. A. Wafford
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background Disturbed sleep is associated with cognitive decline in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The progressive sequence of how neurodegeneration affects aspects of sleep ar
Externí odkaz:
https://doaj.org/article/6e2fef20566947bc9b1bd2fb8d3b2793
Autor:
J M, Witkin, S N, Mitchell, K A, Wafford, G, Carter, G, Gilmour, J, Li, B J, Eastwood, C, Overshiner, X, Li, L, Rorick-Kehn, K, Rasmussen, W H, Anderson, A, Nikolayev, V V, Tolstikov, M-S, Kuo, J T, Catlow, R, Li, S C, Smith, C H, Mitch, P L, Ornstein, S, Swanson, J A, Monn
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(1)
The ability of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8d8a306d81ab2f41cb8a98681e9243c
https://pubmed.ncbi.nlm.nih.gov/28138040
https://pubmed.ncbi.nlm.nih.gov/28138040
Publikováno v:
Pflugers Archiv
Tandem two-pore potassium channels (K2Ps) have widespread expression in the central nervous system and periphery where they contribute to background membrane conductance. Some general anaesthetics promote the opening of some of these channels, enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8531b2deba17c447de86ef5f7964d064
https://pubmed.ncbi.nlm.nih.gov/25482669
https://pubmed.ncbi.nlm.nih.gov/25482669
Publikováno v:
European journal of pain (London, England). 19(4)
Sleep disturbance is a commonly reported co-morbidity in chronic pain patients, and conversely, disruption of sleep can cause acute and long-lasting hypersensitivity to painful stimuli. The underlying mechanisms of sleep disruption-induced pain hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb3b6b34b4bceb66cabd821e9500385d
https://pubmed.ncbi.nlm.nih.gov/25195796
https://pubmed.ncbi.nlm.nih.gov/25195796
Publikováno v:
Journal of Biological Chemistry. 269:32768-32773
Incorporation of the gamma 2 subunit into gamma-aminobutyric acid type A (GABAA) receptors is required for the expression of benzodiazepine pharmacology, but the regions of the subunit responsible for benzodiazepine actions have not been defined. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a831e22d5c116c4dcc5abe207445d3a6
https://doi.org/10.1016/s0021-9258(20)30057-0
https://doi.org/10.1016/s0021-9258(20)30057-0
Autor:
G R, Dawson, K A, Wafford, A, Smith, G R, Marshall, P J, Bayley, J M, Schaeffer, P T, Meinke, R M, McKernan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
Twenty-five avermectin analogs were assessed in a mouse seizure model. The ED(50) against pentylenetetrazole-induced tonic seizures ranged from 0.48 mg/kg (L-676,893) to160 mg/kg (L-685,869) cf. 0. 26 mg/kg for diazepam. Although avermectins are with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ec348d341a308ac44378ab359d4b03a
https://pubmed.ncbi.nlm.nih.gov/11082440
https://pubmed.ncbi.nlm.nih.gov/11082440
Publikováno v:
British journal of pharmacology. 129(8)
Different alpha subunits of human gamma-aminobutyric acid type A (GABA(A)) receptors were transiently expressed together with beta(3) and gamma(2) subunits in Xenopus oocytes to examine the interactions of various GABA(A) agonists and representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbdbbee43b60fcf2eb35f956b80dee3f
https://pubmed.ncbi.nlm.nih.gov/10780988
https://pubmed.ncbi.nlm.nih.gov/10780988
Publikováno v:
British journal of pharmacology. 127(6)
We have mutated a conserved leucine in the putative membrane-spanning domain to serine in human GABA(A) beta2 and investigated the actions of a number of GABA(A) agonists, antagonists and modulators on human alpha1beta2deltaL259Sgamma2s compared to w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d445ae244ef53de7801bc74c92c8b49
https://pubmed.ncbi.nlm.nih.gov/10455284
https://pubmed.ncbi.nlm.nih.gov/10455284
Autor:
T P, Bonnert, R M, McKernan, S, Farrar, B, le Bourdellès, R P, Heavens, D W, Smith, L, Hewson, M R, Rigby, D J, Sirinathsinghji, N, Brown, K A, Wafford, P J, Whiting
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(17)
gamma-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3c3ef7da5e042f2f2fb407d340913f3
https://pubmed.ncbi.nlm.nih.gov/10449790
https://pubmed.ncbi.nlm.nih.gov/10449790
Publikováno v:
Molecular pharmacology. 52(6)
Using human gamma-aminobutyric acid type A (GABAA) receptor subunit combinations, expressed in cell lines and Xenopus laevis oocytes, the pharmacology of a number of ligands interacting directly with the GABA recognition site has been studied in [3H]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d452fba7212e9830975c6acdd7c84b3
https://pubmed.ncbi.nlm.nih.gov/9396785
https://pubmed.ncbi.nlm.nih.gov/9396785