Zobrazeno 1 - 10
of 53
pro vyhledávání: '"K. A. Sharkey"'
Autor:
Liam K. R. Sharkey, Romain Guerillot, Calum J. Walsh, Adrianna M. Turner, Jean Y. H. Lee, Stephanie L. Neville, Stephan Klatt, Sarah L. Baines, Sacha J. Pidot, Fernando J. Rossello, Torsten Seemann, Hamish E. G. McWilliam, Ellie Cho, Glen P. Carter, Benjamin P. Howden, Christopher A. McDevitt, Abderrahman Hachani, Timothy P. Stinear, Ian R. Monk
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTAmong the 16 two-component systems in the opportunistic human pathogen Staphylococcus aureus, only WalKR is essential. Like the orthologous systems in other Bacillota, S. aureus WalKR controls autolysins involved in peptidoglycan remodeling a
Externí odkaz:
https://doaj.org/article/b925679724c74489887fb31d58cddb66
Autor:
Ian R. Monk, Nausad Shaikh, Stephanie L. Begg, Mike Gajdiss, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M. Collins, Gabriele Bierbaum, Saumya R. Udagedara, Jacqueline R. Morey, Neha Pulyani, Benjamin P. Howden, Megan J. Maher, Christopher A. McDevitt, Glenn F. King, Timothy P. Stinear
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhi
Externí odkaz:
https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11
Autor:
Marion Herisse, Andrew H. Buultjens, Tuyet Hoang, Benjamin P Howden, Ian R. Monk, Timothy P. Stinear, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Koen Vandelannoote, Lucy Li, Torsten Seemann
Publikováno v:
ACS Biomaterials Science & Engineering
The COVID-19 pandemic has exposed the dependence of diagnostic laboratories on a handful of large corporations with market monopolies on the worldwide supply of reagents, consumables, and hardware for molecular diagnostics. Global shortages of key co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881794bbefe4a3852a94c231ecdbea1
https://doi.org/10.1021/acsbiomaterials.1c00775
https://doi.org/10.1021/acsbiomaterials.1c00775
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 6:29-29
Background Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract. Despite achieving endoscopic remission, up to 50% of IBD patients continue to experience chronic abdominal pain, with female patients displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4042d6cfa2d4185e37ac69664eebf8
https://doi.org/10.1093/jcag/gwac036.052
https://doi.org/10.1093/jcag/gwac036.052
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which these proteins act has
Externí odkaz:
https://doaj.org/article/935d8092795b4c40a3081ca5adc7ace1
Autor:
Benjamin P Howden, Ian R. Monk, Timothy P. Stinear, Jean Y. H. Lee, Koen Vandelannoote, Andrew H. Buultjens, Liam K. R. Sharkey
Publikováno v:
ACS biomaterials scienceengineering. 7(10)
The ability to detect SARS-CoV-2 is critical to implementing evidence-based strategies to address the COVID-19 global pandemic. Expanding SARS-CoV-2 diagnostic ability beyond well-equipped laboratories widens the opportunity for surveillance and cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5225351c4cd2e496ed29d3048be85c6
https://pubmed.ncbi.nlm.nih.gov/34521204
https://pubmed.ncbi.nlm.nih.gov/34521204
Publikováno v:
Journal of the Canadian Association of Gastroenterology. 5:42-43
Background The inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis, are complex chronic diseases that affect an increasing proportion of the population. Abdominal pain is a major clinical symptom, but current treatments are li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55f20ecafe262f6118aca3523d6f3c25
https://doi.org/10.1093/jcag/gwab049.035
https://doi.org/10.1093/jcag/gwab049.035
Autor:
Alex J. O'Neill, Liam K. R. Sharkey
Publikováno v:
Bacterial Resistance to Antibiotics – From Molecules to Man
All antibiotic resistance mechanisms in bacteria ultimately work by preventing, or mitigating the effects of, an antibacterial inhibitor binding to its cellular target; however, there are a variety of ways by which this effect is achieved. Antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f75a9d2754c05dca0d1dd5419ea22ff
https://doi.org/10.1002/9781119593522.ch2
https://doi.org/10.1002/9781119593522.ch2
Autor:
Jessica L. Porter, Liam K. R. Sharkey, Mark A. Rizzacasa, Sacha J. Pidot, Liselle Atkin, Marion Herisse, Timothy P. Stinear, Torsten Seemann, Benjamin P Howden
Publikováno v:
Angewandte Chemie. 131:4036-4041
The nargenicin family of antibiotics are macrolides containing a rare ether-bridged cis-decalin motif. Several of these compounds are highly active against multi-drug resistant organisms. Despite the identification of the first members of this family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca1398ef50dff1efc17a6909f95eff4
https://doi.org/10.1002/ange.201900290
https://doi.org/10.1002/ange.201900290
Autor:
Liam K. R. Sharkey, Alex J. O'Neill
Publikováno v:
ACS Infectious Diseases. 4:239-246
Members of the ATP-binding cassette (ABC)-F protein subfamily collectively mediate resistance to a broader range of clinically important antibiotic classes than any other group of resistance proteins and are widespread in pathogenic bacteria. Followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdd72230d7103e554895c07bb3a5904
https://doi.org/10.1021/acsinfecdis.7b00251
https://doi.org/10.1021/acsinfecdis.7b00251