Zobrazeno 1 - 10
of 24
pro vyhledávání: '"K. A. Neve"'
Publikováno v:
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 431:366-377
The purpose of this research was to enlarge the applicability of CPAA with reactions leading to short-lived radionuclides ( 0.1 s 1/2 s ). Therefore a set-up for cyclic charged particle activation analysis was designed and built for the isochronous c
Autor:
K. A. Neve, B. L. Wiens
Publikováno v:
Biochemical Society Transactions. 23:112-116
A model describing the binding of catecholamines to receptors has been developed largely on the basis of in nitro mutagenesis of the B,-adrenergic receptor. According to this model, three points of interaction contribute much of the binding energy of
Autor:
K. A. Neve
Publikováno v:
Neuropsychopharmacology. 16:111-113
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
We characterized the effects of drugs on the uptake of [3H]neurotransmitter by and the binding of [125I](3beta-(4-iodophenyl)tropane-2beta-carboxylic acid methyl ester ([125I]RTI-55) to the recombinant human dopamine (hDAT), serotonin (hSERT), or nor
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors
Autor:
V J, Watts, K A, Neve
Publikováno v:
Molecular pharmacology. 50(4)
Prolonged stimulation of Gi-coupled receptors often sensitizes adenylate cyclase to subsequent activation by forskolin or Gs-coupled receptors. To identify mechanisms of heterologous sensitization, we characterized sensitization of cAMP accumulation
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(1)
A 3.5-kilobase cDNA encoding the dopamine transporter was isolated from a human substantia nigra cDNA library. Sequence analysis of the coding region of the transporter identified two nucleotide differences between the cDNA and published human dopami
Publikováno v:
Psychopharmacology. 118(4)
The hallucinogenic effects of lysergic acid diethylamide (LSD) have been attributed primarily to actions at serotonin receptors. A number of studies conducted in the 1970s indicated that LSD also has activity at dopamine (DA) receptors. These latter
Publikováno v:
The Journal of biological chemistry. 269(48)
D1/D2 chimeras were constructed that had D1 dopamine receptor sequence at the amino-terminal end and D2 dopamine receptor sequence at the carboxyl-terminal end. The chimeras with the first four, five and six transmembrane domains of the D1 receptor (
Publikováno v:
Molecular pharmacology. 45(2)
A human dopamine transporter cDNA was cloned and transfected into COS-7 cells, a cell line that lacks vesicular storage and release mechanisms. Cells expressing the dopamine transporter acquired the capacity to take up and release dopamine via the tr
Publikováno v:
The Journal of biological chemistry. 267(36)
A microphysiometer was used to quantify the rate of extracellular acidification by C6 glioma cells and L fibroblasts expressing recombinant dopamine D2 receptors. The dopamine D2 receptor agonist, quinpirole, accelerated the rate of acidification of