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Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease

Autor: John T. Brandt, Rebecca E. Wrishko, David S. Small, Daniel E. Salazar, K. A. Kles, Nagy A. Farid, Ying G. Li, Lan Ni, A. G. Borel, Kenneth J. Winters, Christopher D. Payne, C. S. Ernest

Publikováno v: Journal of clinical pharmacy and therapeutics. 34(5)

Objective: The pharmacokinetic (PK) and pharmacodynamic (PD) responses to prasugrel were compared in three studies of healthy subjects vs. those with moderate or end-stage renal impairment. Methods: Two of the three protocols were parallel-design, op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c56fdf1273aa3711bcb08a717ce2b45
https://pubmed.ncbi.nlm.nih.gov/19744014

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2001 Harry M. Vars Research Award. Enteral nutrients alter enterocyte function within an in vitro model similar to an acute in vivo rat model during hypoxia

Autor: K A, Kles, J R, Turner, K A, Tappenden

Publikováno v: JPEN. Journal of parenteral and enteral nutrition. 26(2)

Early enteral nutrition in patients following traumatic injury is an important intervention. However, after shock-resuscitation, intestinal hypoperfusion persists despite adequate systemic resuscitation. Our previous in vivo rat studies indicate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::073469d0e032f15e0cb95314cef3bf38
https://pubmed.ncbi.nlm.nih.gov/11871739

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