Zobrazeno 1 - 10
of 40
pro vyhledávání: '"K. A. Josephs"'
Autor:
Melissa E. Murray, D. Dickson, Irene Litvan, Ryan J. Uitti, Zbigniew K. Wszolek, Octavio A. Santos, K. A. Josephs, Nobutaka Sakae, Otto Pedraza, Ranjan Duara, Neill R. Graff-Radford
Publikováno v:
Neurology
Neurology, vol 95, iss 1
Neurology, vol 95, iss 1
ObjectiveTo describe clinical and pathologic characteristics of corticobasal degeneration (CBD) with cognitive predominant problems during the disease course.MethodsIn a series of autopsy-confirmed cases of CBD, we identified patients with cognitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa1c4abfd64e50339977fc1a1d6c16b
https://doi.org/10.1212/wnl.0000000000009734
https://doi.org/10.1212/wnl.0000000000009734
Autor:
Hugo Botha, Jennifer L. Whitwell, K. A. Josephs, Kenton R. Kaufman, Stacy R. Loushin, Farwa Ali
Publikováno v:
J Neurol Sci
Background Gait and balance abnormalities are a significant source of morbidity and mortality in progressive supranuclear palsy (PSP). Gait impairment in PSP is primarily assessed clinically on exam or with the use of rating scales. Three dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4085b6f677c45a3a3c7ecb81a55e30c7
https://doi.org/10.1016/j.jns.2021.118054
https://doi.org/10.1016/j.jns.2021.118054
Autor:
Avi Gadoth, St Louis Ek, Sean J. Pittock, Josephe A. Honorat, Hinson, Lederer S, Andrew McKeon, Vanda A. Lennon, Fechner K, Lars Komorowski, Neeraj Kumar, K. A. Josephs
Publikováno v:
Neurology® Neuroimmunology & Neuroinflammation
Objective:To describe the phenotypes, treatment response, and outcome of IgLON5 autoimmunity.Methods:Archived serum and CSF specimens from 367 patients known to harbor unclassified antibodies which stained neural synapses diffusely (mimicking amphiph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e868b028d48b5390e2246fe624fd12ea
https://pubmed.ncbi.nlm.nih.gov/28761904
https://pubmed.ncbi.nlm.nih.gov/28761904
Autor:
Hugo Botha, Jennifer L. Whitwell, Val J. Lowe, K. A. Josephs, Nicholas L. Zalewski, Dennis W. Dickson
Publikováno v:
Journal of Neurology. 261:710-716
The 4-repeat (4R)-tauopathies can be clinically heterogeneous and difficult to diagnose. An FDG-PET pattern of hypometabolism has been previously reported in clinically suspected 4R-tauopathies. Considering that pathological confirmation has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9876b4aa208ed352068d41e65fabcd1
https://doi.org/10.1007/s00415-014-7256-4
https://doi.org/10.1007/s00415-014-7256-4
Autor:
Stephen D. Weigand, Rosa Rademakers, R. C. Petersen, B. F. Boeve, Matt Baker, Z. K. Wszolek, D. S. Knopman, Jennifer L. Whitwell, K. A. Josephs, C. R. Jack, Jeffrey L. Gunter
Publikováno v:
Neurology
Objective: To use multiple serial MRI to assess rates and trajectories of brain and hippocampal atrophy in subjects with frontotemporal dementia (FTD) with progranulin (GRN) or microtubule-associated protein tau (MAPT) gene mutations. Methods: In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5944d5d10861a29fc2540d5d6564378
https://doi.org/10.1212/wnl.0b013e318227047f
https://doi.org/10.1212/wnl.0b013e318227047f
Autor:
Joseph E. Parisi, B. F. Boeve, D. S. Knopman, M. L. Senjem, J. E. Ahlskog, Jennifer L. Whitwell, R. C. Petersen, Daniel A. Drubach, K. A. Josephs, C. R. Jack, Dennis W. Dickson
Publikováno v:
Neurology. 75:1879-1887
Background: Corticobasal syndrome (CBS) can be associated with different underlying pathologies that are difficult to predict based on clinical presentation. The aim of this study was to determine whether patterns of atrophy on imaging could be usefu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd43bd9cc11ac0a0313067ec5435f99d
https://doi.org/10.1212/wnl.0b013e3181feb2e8
https://doi.org/10.1212/wnl.0b013e3181feb2e8
Autor:
K A Josephs
Publikováno v:
Clinical Pharmacology & Therapeutics. 88:555-558
Neurodegenerative dementias are characterized by the deposition of soluble aberrant protein(s). β-Amyloid, the microtubule-associated protein tau, and α-synuclein are the most well-recognized proteins associated with neurodegenerative dementias. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f0b0415b0323d897e0cfead421e86
https://doi.org/10.1038/clpt.2010.112
https://doi.org/10.1038/clpt.2010.112
Autor:
Jennifer L. Whitwell, B. F. Boeve, K. A. Josephs, C. R. Jack, Heidi A. Edmonson, P. Vemuri, D. S. Knopman, Matthew L. Senjem, Ramesh Avula, R. C. Petersen, Kejal Kantarci, Ali R. Samikoglu, S. D. Weigand
Publikováno v:
Neurology. 74:1279-1287
Objective: To use diffusion tensor imaging (DTI) to assess gray matter and white matter tract diffusion in behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SMD), and progressive nonfluent aphasia (PNFA). Methods: This was a case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0580741a9fab4238e9908b521f2463
https://doi.org/10.1212/wnl.0b013e3181d9edde
https://doi.org/10.1212/wnl.0b013e3181d9edde
Autor:
D. S. Knopman, Melissa E. Murray, B. F. Boeve, Jennifer L. Whitwell, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, R. C. Petersen, K. A. Josephs, Scott Przybelski, Dennis W. Dickson, S. D. Weigand, Joseph E. Parisi, C. R. Jack
Publikováno v:
Neurology. 71:743-749
Background: Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea011d0c281e61fcf45b72634d1370b
https://doi.org/10.1212/01.wnl.0000324924.91351.7d
https://doi.org/10.1212/01.wnl.0000324924.91351.7d
Autor:
Claudia F. Lucchinetti, B. M. Keegan, K. A. Josephs, Joseph E. Parisi, B. F. Boeve, Caterina Giannini
Publikováno v:
Neurology. 70:1128-1133
Background: Leukoencephalopathy with neuroaxonal spheroids is a rare cause of severe, subacute dementia that usually presents in childhood and is inherited in an autosomal dominant pattern. The authors present clinical, radiologic, and pathologic fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e5b529ad3c5944b0bd7c070cb47c37
https://doi.org/10.1212/01.wnl.0000304045.99153.8f
https://doi.org/10.1212/01.wnl.0000304045.99153.8f