Zobrazeno 1 - 10
of 414
pro vyhledávání: '"K. A. Garcia"'
Autor:
Buwei Huang, Brian Coventry, Marta T. Borowska, Dimitrios C. Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M. Jude, Samer F. Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Deborah H. Fuller, Ying Mei, K. Christopher Garcia, David Baker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory cytokines involv
Externí odkaz:
https://doaj.org/article/5f93a3f590e5444ea2f8d8872b6aedb3
Decrease in platelet count in patients with AKI and its association with major adverse kidney events
Autor:
Ramón Medina-González, Jose J. Zaragoza, Eduardo M. Hernández-Barajas, Juarez Correa-de Leon, Rolando Claure-Del Granado, Armando Vazquez-Rangel, Liliana M. Pineda-Segura, Martha K. Franco-Garcia, Gael Chávez-Alonso, Juan A. Gómez-Fregoso, Francisco G. Rodríguez-García, Guillermo Navarro-Blackaller, Luz Alcantar-Vallin, Alejandro Martínez Gallardo-González, Gabriela J. Abundis-Mora, Guillermo García-García, Jonathan S. Chávez-Iñiguez
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Introduction A reduction in platelet count in critically ill patients is a marker of severity of the clinical condition. However, whether this association holds true in acute kidney injury (AKI) is unknown. We analyzed the association between platele
Externí odkaz:
https://doaj.org/article/727b965aa94f45f387bb77748d6e0091
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Angela M. Marcobal, Bruce R. McConnell, Riley A. Drexler, Katharine M. Ng, Maria X. Maldonado-Gomez, Alexandria M. S. Conner, Cory G. Vierra, Nithya Krishnakumar, Hannah M. Gerber, Jada K. A. Garcia, James P. Cerney, Matthew J. Amicucci
Publikováno v:
Nutrients, Vol 16, Iss 14, p 2240 (2024)
β-glucans found in cereal grains have been previously demonstrated to improve blood glucose control; however, current understanding points to their high viscosity as the primary mechanism of action. In this work, we present a novel, highly soluble,
Externí odkaz:
https://doaj.org/article/51a1518308cc40dfa41b4f7766ecfbd5
Autor:
Elsa K. Vargas-Garcia, Augusto R. Fernandez-Aristi, Gonzalo Cornejo-Venegas, Juan José Montenegro-Idrogo, Juan Chirinos-Vega, Alfredo Chiappe-Gonzalez
Publikováno v:
AIDS Research and Therapy, Vol 20, Iss 1, Pp 1-5 (2023)
Abstract Background Actinomycosis is an unusual chronic bacterial infection, even rarer in people living with HIV. It is not considered an AIDS-defining disease. However, the role in co-presentation or overlap with other opportunistic conditions of a
Externí odkaz:
https://doaj.org/article/14a8630abff845849d4ecb0aa085a913
Autor:
Robert A. Saxton, Nathanael A. Caveney, Maria Dolores Moya-Garzon, Karsten D. Householder, Grayson E. Rodriguez, Kylie A. Burdsall, Jonathan Z. Long, K. Christopher Garcia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons. Leptin signaling is dysregulated in obesity, how
Externí odkaz:
https://doaj.org/article/3604942e453f41839c0e226870f2d718
Autor:
Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Engineered cytokine–based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic mu
Externí odkaz:
https://doaj.org/article/e315efdb0cc249018ebbc3ca54aedce4
Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
Publikováno v:
eLife, Vol 12 (2023)
Membrane receptor guanylyl cyclases play a role in many important facets of human physiology, from regulating blood pressure to intestinal fluid secretion. The structural mechanisms which influence these important physiological processes have yet to
Externí odkaz:
https://doaj.org/article/ada6185b57404e9a96de23bac941bf17
Autor:
Gita C. Abhiraman, Theodora U.J. Bruun, Nathanael A. Caveney, Leon L. Su, Robert A. Saxton, Qian Yin, Shaogeng Tang, Mark M. Davis, Kevin M. Jude, K. Christopher Garcia
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112657- (2023)
Summary: Interleukin-21 (IL-21) plays a critical role in generating immunological memory by promoting the germinal center reaction, yet clinical use of IL-21 remains challenging because of its pleiotropy and association with autoimmune disease. To be
Externí odkaz:
https://doaj.org/article/ff558ab89c5744beb43d3fcb68643740
Autor:
J. L. Rolando, M. Hodges, K. D. Garcia, G. Krueger, N. Williams, J. Carr Jr., J. Robinson, A. George, J. Morris, J. E. Kostka
Publikováno v:
Ecosphere, Vol 14, Iss 4, Pp n/a-n/a (2023)
Abstract The frequency of salt marsh dieback events has increased over the last 25 years with unknown consequences to the resilience of the ecosystem to accelerated sea level rise (SLR). Salt marsh ecosystems impacted by sudden vegetation dieback eve
Externí odkaz:
https://doaj.org/article/04d8b53d0b2946a0998bac534c037fe2