Výsledky vyhledávání - "K. A. Al-Sakkaf"

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation

Autor: Barry L. Brown, Pauline R.M. Dobson, Omar S. El-Masry, K. A. Al-Sakkaf

Publikováno v: Oncology Reports

AMP-activated protein kinase (AMPK), a sensor of cellular energy, is widely reported as a potential therapeutic target in treatment of breast and other cancers. The activated enzyme has been shown to be a promising anti-proliferative agent in breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8498a69ef742255cf073bf2301663
https://doi.org/10.3892/or.2015.4198

Zobrazit plný text záznamu

The Survival Effect of Prolactin on PC3 Prostate Cancer Cells

Autor: Colby L. Eaton, Freddie C. Hamdy, A. Ruffion, Pauline R.M. Dobson, Barry L. Brown, K. A. Al-Sakkaf

Publikováno v: European Urology. 43:301-308

Objectives: Recent studies suggest a paracrine/autocrine loop involving prolactin (PRL) within the human prostate. The aims of this study were to determine the effects of PRL on the growth and survival of prostate cancer cells and the intracellular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c0eee1ffca53d5b979474e3aab0450
https://doi.org/10.1016/s0302-2838(03)00038-1

Zobrazit plný text záznamu

Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells

Autor: K. A. Al-Sakkaf, Pauline R.M. Dobson, L. M. Mooney, Barry L. Brown

Publikováno v: British Journal of Cancer

To investigate the mechanisms underlying apoptosis in breast cancer cells, staurosporine was used as an apoptotic stimulus in the human breast cancer cell lines MCF-7 and T47D. Staurosporine induced dose and time dependent increases in DNA fragmentat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7fbcd459b0a09becdb3d5579180924
https://doi.org/10.1038/sj.bjc.6600541

Zobrazit plný text záznamu

Possible role for protein kinase B in the anti-apoptotic effect of prolactin in rat Nb2 lymphoma cells

Autor: Barry L. Brown, K. A. Al-Sakkaf, Pauline R.M. Dobson, L. M. Mooney

Publikováno v: Journal of Endocrinology. 167:85-92

Prolactin (PRL) is a mitogen for a number of cell types and its action as a survival factor has recently been demonstrated in Nb2 lymphoma cells. However, the intracellular signalling pathways by which PRL promotes the survival of Nb2 cells is unknow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeafb0d07386fedc0155f4e874e959ce
https://doi.org/10.1677/joe.0.1670085

Zobrazit plný text záznamu

Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells

Autor: K. A. Al-Sakkaf, B. L. Brown, Pauline R.M. Dobson

Publikováno v: Journal of Molecular Endocrinology. 19:347-350

Our previous studies indicated that PI3-kinase is involved in prolactin (PRL) signalling. We have now examined the involvement of the src tyrosine kinase, fyn, in PRL-induced the activation of PI3-kinase in the rat lymphoma cell line, Nb2. Cells were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9126b825e41327bbea9f3c2363236e
https://doi.org/10.1677/jme.0.0190347

Zobrazit plný text záznamu

Activation of Phosphatidylinositol 3-Kinase by Prolactin in Nb2 Cells

Autor: K. A. Al-Sakkaf, Pauline R.M. Dobson, Barry L. Brown

Publikováno v: Biochemical and Biophysical Research Communications. 221:779-784

In the present studies, using anti-phosphotyrosine (PY20) and PI3-kinase (p85) antibodies, we have shown that PRL causes activation of phosphatidyl inositol 3-kinase (PI3-kinase) in vitro in a dose- and time-dependent manner in Nb2 cells. PRL activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c79ada22f59f2d9b336c9c2b7addeb
https://doi.org/10.1006/bbrc.1996.0673

Zobrazit plný text záznamu

Enhanced anti-cancer effect of a phosphatidylinositol-3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status

Autor: Barry L. Brown, Pauline R.M. Dobson, Leeza M. McCarragher, Yan A. Wang, K. A. Al-Sakkaf, Janice A. Royds, Stuart K. Johnson

Publikováno v: International journal of cancer. 123(7)

New efforts are being focused on signalling pathways as targets for cancer therapy. This particular study was designed to investigate whether blockade of the phosphatidylinositol 3OH-kinase (PI3K) pathway (a survival/anti-apoptosis pathway, overexpre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4d08f334a6c2b776761cb4de3ece9c
https://pubmed.ncbi.nlm.nih.gov/18634052

Zobrazit plný text záznamu

Cytokine-induced activation of protein kinases in breast cancer cells

Autor: Barry L. Brown, Pauline R.M. Dobson, C. H. Dawson, James E. Dunford, K. A. Al-Sakkaf, G. Page

Publikováno v: Cytokine. 6:578

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4645a6c87a066c132a638e27737e2e17
https://doi.org/10.1016/1043-4666(94)90308-5

Zobrazit plný text záznamu

Akademický článek

CHILDHOOD IMMUNISATION AND ITS DETERMINANTS IN ADEN-YEMEN.

Autor: K. A., Al-Sakkaf^1,2, K., Shamsuddin¹

Publikováno v: Malaysian Journal of Medical Sciences. Jul2008 Supplement, p51-51. 1p.

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání