Zobrazeno 1 - 10
of 1 999
pro vyhledávání: '"K.‐L. Wong"'
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/8593703fd3cb4359b2b63cc250e50724
Publikováno v:
Korean Journal of Anesthesiology, Vol 75, Iss 1, Pp 47-60 (2022)
Background Diabetes is a risk factor for postoperative complications. Previous meta-analyses have shown that elevated glycated hemoglobin (HbA1c) levels are associated with postoperative complications in various surgical populations. However, this is
Externí odkaz:
https://doaj.org/article/3635c62614ff48bd90238e96918a59c4
Autor:
John K. L. Wong, Christian Aichmüller, Markus Schulze, Mario Hlevnjak, Shaymaa Elgaafary, Peter Lichter, Marc Zapatka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In cancer, associations between mutational signatures and driver mutations have been proposed but not fully explored. Here, the authors develop sigDriver to find associations between mutational signatures and mutation hotspots in order to predict cod
Externí odkaz:
https://doaj.org/article/10fbc2005901429d9626f59668cfc6e4
Autor:
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010262 (2022)
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood. We explored the roles of deoxyribonuclease 1 (DNASE1) and deoxyribonuclease 1-like 3 (DNA
Externí odkaz:
https://doaj.org/article/d9987df5b47d4a6084458cedce82ae43
Autor:
Natalia Voronina, John K. L. Wong, Daniel Hübschmann, Mario Hlevnjak, Sebastian Uhrig, Christoph E. Heilig, Peter Horak, Simon Kreutzfeldt, Andreas Mock, Albrecht Stenzinger, Barbara Hutter, Martina Fröhlich, Benedikt Brors, Arne Jahn, Barbara Klink, Laura Gieldon, Lina Sieverling, Lars Feuerbach, Priya Chudasama, Katja Beck, Matthias Kroiss, Christoph Heining, Lino Möhrmann, Andrea Fischer, Evelin Schröck, Hanno Glimm, Marc Zapatka, Peter Lichter, Stefan Fröhling, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The shattering of chromosomes is a dramatic early event in tumourigenesis and is termed chromothripsis. Here, the authors examine chromothripsis across 28 tumour types and show that 49% of cancers exhibit features of chromothripsis.
Externí odkaz:
https://doaj.org/article/bfa7b0c2c5f44dfead7de201eaa3b1b2
Autor:
Ke Yang, Shiqian Wu, Oluwarotimi W. Samuel, Hui Zhang, Dhanjoo N. Ghista, Di Yang, Kelvin K. L. Wong
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Objective: The measurement of cardiac blood flow vortex characteristics can help to facilitate the analysis of blood flow dynamics that regulates heart function. However, the complexity of cardiac flow along with other physical limitations makes it d
Externí odkaz:
https://doaj.org/article/5554e18569744e0997ff4135c1b475bf
Publikováno v:
Frontiers in Physics, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/c9390dc731694d998883617c7467596e
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
Autor:
Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromothripsis and chromoanasynthesis lead to locally clustered rearrangements affecting one or a few chromosomes, but their impact on cancer development and progression is unclear. Here the authors analyse the role of DNA repair factors in brain tum
Externí odkaz:
https://doaj.org/article/8c14a72fa08b47349febd37357e6a636
Autor:
Raneem Habib, Heidemarie Neitzel, Aurelie Ernst, John K. L. Wong, Bozenna Goryluk-Kozakiewicz, Antje Gerlach, Ilja Demuth, Karl Sperling, Krystyna Chrzanowska
Publikováno v:
Molecular Cytogenetics, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background Nijmegen breakage syndrome is an autosomal recessive disorder characterized by microcephaly, immunodeficiency, hypersensitivity to X-irradiation, and a high predisposition to cancer. Nibrin, the product of the NBN gene, is part of
Externí odkaz:
https://doaj.org/article/ea6b73b7893847ec9d22ae687d41b9a8
Publikováno v:
IEEE Access, Vol 6, Pp 22728-22743 (2018)
Recently, a new algorithm named dynamic group optimization (DGO) has been proposed, which is developed to mimic the behaviors of animal and human group socializing. However, one of the major drawbacks of the DGO is the premature convergence. Therefor
Externí odkaz:
https://doaj.org/article/e9fac6656522473ba12382663d388f37