Zobrazeno 1 - 10 of 60 pro vyhledávání: '"K.‐H. Baringhaus"'
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Synthesis and Biological Activity of Bile Acid-Derived HMG-CoA Reductase Inhibitors. The Role of 21-Methyl in Recognition of HMG-CoA Reductase and the Ileal Bile Acid Transport System
Autor: X B Han, Alfons Enhsen, Guenther Dr Wess, K.‐H. Baringhaus, Klaus Bock, Werner Kramer, Heiner Glombik, G Böger, A. Hoffmann, Matthias Urmann
Publikováno v: Journal of Medicinal Chemistry. 37:3240-3246
To increase hepatoselectivity of HMG-CoA reductase inhibitors by using the specific bile acid transport systems, deoxycholic acid-derived inhibitors 9 and 11 have been synthesized, on the basis of the concept of combining in one molecule structural r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a49ce28f590ac76a20fdd613a00b3d7
https://doi.org/10.1021/jm00046a007
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2
Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues
Autor: H Burghard, E Baader, K H Baringhaus, Georg Tschank, V Günzler
Publikováno v: Biochemical Journal. 300:525-530
The potency of oxalyl amino acid derivatives as inhibitors of prolyl 4-hydroxylase was studied in vitro, in isolated microsomes and in chicken embryonic-tissue culture. These compounds represent structural analogues of 2-oxoglutarate in which the -CH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1540665834fee0a31a47adfecec1d8ca
https://doi.org/10.1042/bj3000525
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3
Synthesis of bile acid - drug conjugates: Potential drug - shuttles for liver specific targeting
Autor: H. Kleine, K.‐H. Baringhaus, M. John, W. Kramer, Klaus Bock, O. Neckermann, Alfons Enhsen, A. Hoffmann, Gerrit Schubert, Heiner Glombik, G. Wess, S. Müllner
Publikováno v: Tetrahedron Letters. 34:819-822
Cholic acid (1) has been coupled via ω-aminoalkoxy spacer at C-3 to chlorambucil (3), HR 780 (4) and oxaproline peptide (5). Drug conjugates 9, 11, 18 exhibit strong affinity to specific bile acid transport systems.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5bd9e6acfecda3cacebc6abc9217570
https://doi.org/10.1016/0040-4039(93)89021-h
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8
3D QSAR of Prolyl 4-Hydroxylase Inhibitors
Autor: G. Schubert, K. Weidmann, V. Guenzler-Pukall, K.-H. Baringhaus
Publikováno v: Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Prolyl 4-hydroxylase (EC 1.14.11.2) is an important enzyme involved in collagen biosynthesis. This enzyme catalyzes the formation of 4-hydroxyproline in collagens by the hydroxylation of certain proline residues in peptide linkages1. Due to the impor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f20e5531b7b29fe6ad0412d527db825c
https://doi.org/10.1007/978-1-4615-4141-7_70
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9
Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor
Autor: M, Bickel, K H, Baringhaus, M, Gerl, V, Günzler, J, Kanta, L, Schmidts, M, Stapf, G, Tschank, K, Weidmann, U, Werner
Publikováno v: Hepatology (Baltimore, Md.). 28(2)
Fibrosis and cirrhosis of the liver are often the result of chronic liver damage by a variety of different agents. Pathological accumulation of collagen, disruption of the lobular structure, and impaired hepatocellular function frequently lead to sys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78bd4f8218aa5908fcdb127343d65d9d
https://pubmed.ncbi.nlm.nih.gov/9696004
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10
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